Dr Manasi Nandi
Lecturer in Integrative Pharmacology
Telephone number: +44 (0)207 848 4446
Email address: email@example.com
King's Postal Address:
Institute of Pharmaceutical Science
King's College London
3rd Floor, Franklin-Wilkins Building
150 Stamford Street
London SE1 9NH
Dr Manasi Nandi is a Senior Lecturer in Integrative Pharmacology. Her research focuses on cardiovascular regulation, in disorders including pulmonary hypertension and septic shock. She has used pharmacological, disease modifying and genetically modified systems, undertaking an integrative approach, to identify novel therapeutic targets for the treatment of vascular dysfunction. She completed her PhD at the Institute of Child Health and post doctoral training at University College London in the laboratory of Professor Patrick Vallance. During this time, she developed a number of in vivo systems to characterise a novel mouse mutant and small molecule, and identified a nitric oxide modifying pathway as a novel target for the treatment of septic shock. This project led to the award of a Wellcome Trust Seeding Drug Discovery Grant to UCL, on which she was the biology project manager. She was awarded a British Heart Foundation Intermediate Fellowship immediately prior to commencing her lectureship at King’s College London in 2009.
Since joining King’s, her research has been supported by funders including the British Heart Foundation, BBSRC, University of London and The Royal Society.
Current Research Interests:
1) The investigation of nitric oxide modifying pathways including the role and regulation of tetrahydrobiopterin (a nitric oxide synthase cofactor) in the progression of hypertension and septic shock.
2) The development of translatable preclinical research models to understand whole body responses to sepsis, trauma and other cardiovascular diseases with a particular focus multi-parameter analysis including hemodynamic and blood flow measurements in the macro and micro circulation.
3) The refinement of preclinical models to improve experimental animal welfare whilst optimising scientific outputs (in conjunction with an RSPCA expert working group)
4) The detailed investigation of physiological waveforms (e.g. blood pressure) using a novel mathematical method developed by Dr Philip Aston (Reader in Mathematics, University of Surrey). The project is currently partnering up with physiologists and clinicians within King’s Health Partners and beyond to translate the maths outputs to the patient’s bedside.
The project was showcased as part of the KCL bid for the BBSRC Activating Impact Award.
Manasi is also involved in undergraduate and graduate teaching within the college. Her primary teaching responsibility is as organiser for a Drug Safety and Toxicology, final year undergraduate module - co-developed with Dr Jude Hall. The module guides students through the drug discovery and development pipeline with a particular focus on how the safety of new medicines is assessed at every stage. The strength of this module lies in the external pharmaceutical industry, clinical trial and regulatory experts who deliver bespoke teaching to the students. The course also utilises a number of E-learning tools and workshop approaches to move away from traditional didactic lectures, facilitating active learning. Manasi was awarded the British Pharmacological Society Rang Prize for teaching excellence in 2015, primarily for her work on this module.
Manasi is a STEM ambassador and has undertaken a number of school and university visits describing her research in addition to attending career development workshops. She has hosted a number of A-level students in her laboratory partnering with organisations such as the Nuffield Research Placement Scheme.
Manasi will be co-presenting an exhibit with Dr Philip Aston (mathematician), at the London Science Museum in November 2015 - showcasing the application of mathematics to different areas of research and the impacts of interdisciplinary collaboration. The exhibit will form a manned live display that has been curated by the theatre company Non Zero One. Members of the public will be able to visualise their own cardiovascular system as a dynamically changing 'cardiomorph'.
A video describing the method can be found here: