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PBG Alumni

Dr Pedro Fale

pedro-fale-140-180Franklin-Wilkins Building (5.22B)

150 Stamford Street

London, SE1 9NH

Email: pedro.vieira_fale@kcl.ac.uk

 

 

 

About Pedro

Dr Pedro Fale graduated with a PhD degree in Pharmaceutical and Toxicological Biochemistry at the Faculty of Sciences of the University of Lisbon, Portugal, funded by the Portuguese Foundation for Science and Technology (FCT). He was involved in the study of natural products with potential pharmacological value, accessing their bioavailability, biological effects and interactions with prescription drugs, using label free methods based on HPLC, UV-Vis and mass spectrometry.

In May 2014 Dr Fale moved to KCL as a post-doc researcher in an EPSRC-funded project led by Dr K. L. Andrew Chan, aiming for the development of a label-free non-destructive method based on ATR-FTIR spectroscopy to measure the diffusion of drugs through biological material. Dr Fale’s research interests also involve the study of the biochemical effects of drugs on cells using label-free methods, and the development of new label-free non-destructive spectroscopic methods to allow these studies on live cells.

Publications

  1. Falé PL, Ferreira C, Rodrigues AM, Frazão FN, Serralheiro MLM. 2014. Studies on the molecular mechanism of cholesterol reduction by Fraxinus angustifolia, Peumus boldus, Cynara cardunculus and Pterospartum tridentatum infusions. Journal of Medicinal Plants Research, 8: 9-17.
  2. Falé PL, Ferreira C, Maruzzella F, Florêncio MH, Frazão FN, Serralheiro ML. 2013. Evaluation of cholesterol absorption and biosynthesis by decoctions of Annona cherimola leaves. Journal of Ethnopharmacology, 150: 718-723.
  3. Falé PL, Ferreira C, Rodrigues AM, Cleto P, Madeira PJA, Florêncio MH, Frazão FN, Serralheiro ML. 2013. Antioxidant and antiacetylcholinesterase activity of commercially available medicinal infusions after in vitro gastrointestinal digestion. Journal of Medicinal Plant Research, 7:1370-1378.
  4. Falé PL, Ascensão L, Serralheiro MLM. 2013. Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers. Food Funct. 4:426-431.
  5. Falé PL, Ascensão L, Serralheiro MLM, Haris PI. 2012. Interaction between Plectranthus barbatus herbal tea components and acetylcholinesterase: binding and activity studies. Food Funct. 3:1176-1184.
  6. Falé PL, Amaral F, Amorim Madeira PJ, Sousa Silva M, Florêncio MH, Frazão FN, Serralheiro ML. 2012. Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. Food Chem Toxicol. 50:2656-2662.
  7. Gil DMA, Falé PL, Serralheiro MLM, Rebelo MJF. 2011. Herbal infusions bioelectrochemical polyphenolic index: Green tea – The gallic acid interference. Food Chem. 129: 1537-1543.
  8. Falé PL, Madeira PJ, Florêncio MH, Ascensão L, Serralheiro MLM. 2011. Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitor. Food Funct. 2: 130-136.
  9. Porfirio S, Falé PL, Madeira PJA, Florêncio H, Ascensão L, Serralheiro MLM. 2010. Antiacetylcholinesterase and antioxidant activities of Plectranthus barbatus tea, after in vitro gastrointestinal metabolism, Food Chem. 122: 798–805.
  10. Cruz D, Falé PL, Mourato A, Vaz PD, Serralheiro ML, Lino AR.2010. Preparation and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena). Colloids Surf B Biointerfaces. 81: 67-73.
  11. Falé PL, Borges C, Madeira PJA, Ascensão L, Araújo MEM, Florêncio MH, Serralheiro MLM. 2009. Rosmarinic acid, scutellarein 4’-methyl ether 7-O-glucuronide and (16S)-coleon E are the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus (‘‘falso boldo”). Food Chem. 114: 798–805.


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