Dr Pedro Fale
Franklin-Wilkins Building (5.22B)
150 Stamford Street
London, SE1 9NH
Dr Pedro Fale graduated with a PhD degree in Pharmaceutical
and Toxicological Biochemistry at the Faculty of Sciences of the University of
Lisbon, Portugal, funded by the Portuguese Foundation for Science and
Technology (FCT). He was involved in the study of natural products with
potential pharmacological value, accessing their bioavailability, biological
effects and interactions with prescription drugs, using label free methods
based on HPLC, UV-Vis and mass spectrometry.
In May 2014 Dr Fale moved to KCL as a post-doc researcher in
an EPSRC-funded project led by Dr K. L. Andrew Chan, aiming for the development
of a label-free non-destructive method based on ATR-FTIR spectroscopy to
measure the diffusion of drugs through biological material. Dr Fale’s research
interests also involve the study of the biochemical effects of drugs on cells
using label-free methods, and the development of new label-free non-destructive
spectroscopic methods to allow these studies on live cells.
- Falé PL, Ferreira C, Rodrigues AM, Frazão FN, Serralheiro MLM. 2014. Studies on the molecular
mechanism of cholesterol reduction by Fraxinus
angustifolia, Peumus boldus, Cynara cardunculus and Pterospartum tridentatum infusions.
Journal of Medicinal Plants Research, 8: 9-17.
- Falé PL, Ferreira C, Maruzzella F, Florêncio MH, Frazão FN, Serralheiro ML. 2013. Evaluation of cholesterol absorption and
biosynthesis by decoctions of Annona
cherimola leaves. Journal of
Ethnopharmacology, 150: 718-723.
- Falé PL, Ferreira C, Rodrigues AM, Cleto P, Madeira PJA, Florêncio MH, Frazão
FN, Serralheiro ML. 2013. Antioxidant and
antiacetylcholinesterase activity of commercially available medicinal infusions
after in vitro gastrointestinal
digestion. Journal of Medicinal Plant Research, 7:1370-1378.
- Falé PL, Ascensão L, Serralheiro MLM. 2013.
luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell
monolayers. Food Funct. 4:426-431.
- Falé PL, Ascensão L, Serralheiro MLM, Haris PI. 2012. Interaction between Plectranthus
barbatus herbal tea components and acetylcholinesterase: binding and
activity studies. Food Funct. 3:1176-1184.
- Falé PL, Amaral F, Amorim Madeira PJ, Sousa Silva M, Florêncio MH, Frazão FN,
Serralheiro ML. 2012. Acetylcholinesterase
inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. Food Chem
- Gil DMA, Falé PL, Serralheiro MLM, Rebelo
MJF. 2011. Herbal infusions
bioelectrochemical polyphenolic index: Green tea – The gallic acid
interference. Food Chem. 129:
- Falé PL, Madeira PJ, Florêncio MH, Ascensão L, Serralheiro MLM. 2011. Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase
inhibitor. Food Funct. 2: 130-136.
- Porfirio S, Falé
PL, Madeira PJA, Florêncio H, Ascensão L, Serralheiro MLM. 2010. Antiacetylcholinesterase and antioxidant
activities of Plectranthus barbatus
tea, after in vitro gastrointestinal
metabolism, Food Chem. 122: 798–805.
- Cruz D, Falé PL, Mourato A, Vaz PD,
Serralheiro ML, Lino AR.2010. Preparation
and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena). Colloids Surf B Biointerfaces. 81: 67-73.
- Falé PL, Borges C, Madeira PJA, Ascensão L, Araújo MEM, Florêncio MH,
Serralheiro MLM. 2009. Rosmarinic acid,
scutellarein 4’-methyl ether 7-O-glucuronide and (16S)-coleon E are the main
compounds responsible for the antiacetylcholinesterase and antioxidant activity
in herbal tea of Plectranthus barbatus
(‘‘falso boldo”). Food Chem. 114: 798–805.