Dr Tokuwa Kanno
Franklin-Wilkins Building (5.22B)
150 Stamford Street
London, SE1 9NH
Tokuwa completed his BSc in Biochemistry at King's College London in 2012, obtaining a first class degree, and took up a four year PhD position funded by the Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. During his undergraduate studies, Tokuwa undertook a summer studensthip in Dr Mason's laboratory, working on self-association of anti-cancer peptides.
Following three four-month rotations in 2012-13 he undertook a project with Dr Mason and jointly supervised by Dr Victoria Sanz-Moreno and Dr Geoff Charles-Edwards. Tokuwa's project used an integrated NMR metabolomic approach to better understand how actomyosin contractility is related to cancer cell movement and metastatic spread. 90% of cancer related deaths are due to metastatic spread and a better understanding of the pathways that control movement strategies in invasive cancer cells can be used to discover new points of intervention and therapies and improve the quality of diagnoses.
In addition he integrated next generation sequencing and NMR metabolomic data to understand the relationships between microbiome and metabolome in the gut following antibiotic administration. On successful completion of his PhD he worked on a joint project with Dr Rachel Tribe, initially supported by the King's Together scheme before taking up a job with Janssen.
- Wang, Y., Leong, L.E.X., Keating, R.L., Kanno, T., Abell, G.C., Mobegi, F., Choo, J.M., Wesselingh, S.L., Mason, A.J., Burr, L.C. & Rogers, G.B. Opportunistic bacteria confer the ability to ferment prebiotic starch in the adult cystic fibrosis gut. Gut Microbes 2018 DOI:10.1080/19490976.2018.1534512
- Man, D.K-W., Kanno, T., Manzo, G., Robertson, B.D., Lam, J.K.W. & Mason, A.J.* Rifampicin or capreomycin induced remodelling of the Mycobacterium smegmatis mycolic acid layer is mitigated in synergistic combinations with cationic antimicrobial peptides. mSphere 2018 3: e0218-18
- Choo, J., Kanno, T., Zain, M.M., Leong, L.E.X., Abell, G.C.J., Keeble, M.J., Bruce, K.D., Mason, A.J.* & Rogers, G.B.* Divergent relationships between faecal microbiota and metabolome following distinct antibiotic-induced disruptions.mSphere 2017 2:e00005-17
- Honeth, G., Schiavinotto, T., Vaggi, F., Marlow, R., Kanno, T., Shinomiya, I., Lombardi, S., Buchipalli, B., Graham, R., Gazinska, P., Ramalingam, V., Burchell, J., Purushotham, A.D., Pinder, S.E., Csikasz-Nagy, A., & Dontu, G. Models of breast morphogenesis based on localization of stem cells in the developing mammary lobule. Stem Cell Reports 2015 (4) 699-711
- Vermeer, L.S., Lan, Y., Abbate, V., Ruh, E., Bui, T.T., Wilkinson, L., Kanno, T., Jumagulova, E., Kozlowska, J., Patel, J., McIntyre, C.A., Yam, W.C., Siu, G., Atkinson, R.A., Lam, J.K.W., Bansal, S.S., Drake, A.F., Mitchell, G.H. & Mason, A.J. Conformational flexibility determines selectivity and anti-bacterial, antiplasmodial and anticancer potency of cationic α-helical peptides. J. Biol. Chem. 2012 (287) 34120-34133