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PBG Alumni

Dr Yun Lan

Fluo,Yan140x180 
Email: yunlan@hku.hk

 

 

 

 

About Yun

Yun completed her MSc in Pharmaceutical Analysis and Quality Control (PAQC) at King's College London in 2008 and joined Dr Mason's lab as a research assistant under the Tier 1 scheme, funded by the MRC. She became highly proficient in peptide purification, CD spectroscopy, fluorescence spectroscopy, and both anti-bacterial and anti-plasmodial testing.

In September 2010 she took up a place as a PhD student with Dr Mason's collaborator, Dr Jenny Lam, in the Department of Pharmacology and Pharmacy of the University of Hong Kong (HKU). Yun completed her PhD studies in December 2014, congratulations!

Publications:
  1. Lan, Y., Lam, J.T., Siu, G.K.H., Yam, W.C., Mason, A.J. & Lam, J.K.W. Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis. Tuberculosis 2014 (94) 678-689
  2. Abbate, V., Liang, W., Patel, J., Lan, Y., Capriotti, L., Iacobucci, V., Bui, T.T., Chaudhuri, P., Kudsiova, L., Vermeer, L.S., Chan, P.F.L., Kong, X., Drake, A.F., Lam, J.K.W., Bansal, S.S. & Mason, A.J. Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity. J. Control. Release 2013 (172) 929-938
  3. Tripathy, N., Lan, Y., Lam, J.K.W., Vanhoutte, P.M. & Hahn, Y-B. Comprehensive study on the toxicology of surface-coated ZnO nanoparticles in human alveolar adenocarcinoma (A549) cells. Science of Advanced Materials 2013 (5) 421-429.
  4. Vermeer, L.S., Lan, Y., Abbate, V., Ruh, E., Bui, T.T., Wilkinson, L., Kanno, T., Jumagulova, E., Kozlowska, J., Patel, J., McIntyre, C.A., Yam, W.C., Siu, G., Atkinson, R.A., Lam, J.K.W., Bansal, S.S., Drake, A.F., Mitchell, G.H. & Mason, A.J. Conformational flexibility determines selectivity and anti-bacterial, -Plasmodial and -cancer potency of cationic α-helical peptides. J. Biol. Chem. 2012 (287) 34120-34133 
  5. Lam, J.K.W., Liang, W., Lan, Y., Chaudhuri, P., Chow, M.Y.T., Witt, K., Kudsiova, L., & Mason, A.J. Effective endogenous gene silencing mediated by pH responsive amphipathic peptides proceeds via multiple pathways. J. Control. Release 2012 (158) 293-303
  6. Lan, Y., Yan, Y., Kozlowska, J., Lam, J.K., Drake, A & Mason A.J. Structural contributions to the intracellular targeting strategy of antimicrobial peptides. Biochim. Biophys. Acta 2010 (1798) 1934-1943
  7. Lan, Y., Langlet-Bertin, B., Abbate, V., Vermeer, L., Kong, X., Sullivan, K., Leborgne, C., Scherman, D., Hider, R.C., Drake, A.F., Bansal, S., Kichler, A. & Mason, A.J.* Incorporation of 2,3-diaminopropionic acid in linear cationic amphipathic peptides produces pH sensitive vectors. ChemBioChem 2010 (11), 1266-1272
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