About Biostatistics & Health Informatics
The department has been a major force in the development of quantitative methodology as applied to mental health research, with significant national and international collaborations, and with growing impact into all areas of medicine particularly through expertise in trials and software development. The department is organised into two groups, though we often work closely together on projects.
The Biostatistics Group is made up largely of statisticians. We have five primary areas of methodological and applied research: prediction modelling and personalized medicine; causal evaluation and the analysis of therapeutic mechanism; the Psychometrics & Measurement Lab; life course research; and mental health clinical trial statistics and methodology. Our statisticians also provide statistical collaboration for both introductory and advanced training in applied statistical methodology.
The Institute has had a dedicated biostatistics department since 1964, opened then as the Biometrics Unit by Professor A.E. Maxwell, and now headed by Professor Daniel Stahl.
We led the Trials, Genomics and Prediction theme [RE1] of the NIHR Maudsley Biomedical Research Centre[RE2] , that aims to deliver a step-change in patient-centred, data-driven mental health research at scale.
The department is host of the national NIHR Research Support Service Hub specialising in Mental Health and Neuroscience. It provides a comprehensive framework for research design, development, collaboration, and implementation and offers continuous assistance from the initial pre-application stages to the subsequent post-application phases.The department supports the UKCRC accredited King's Clinical Trials Unit which provides randomisation, data management, trial management and statistical analysis for a growing portfolio of clinical trials in all health and social care.
The Health Informatics Group at the Department of Biostatistics & Health Informatics is headed by Professor Richard Dobson. The Group's research is focused on translational bioinformatics and its application to complex disease. It is comprised of a mix of data and computer scientists, research software engineers and clinical & bio-informaticians, focused on the use of data from 'omics, electronic health records, the exposome, smartphones and wearables for real-time tailored care and alerting, trial recruitment, patient stratification and research. This multi-disciplinary team is able to develop and implement solutions for analysing and interpreting complex integrative datasets and for communicating findings to clinicians and patients.
Via the NIHR Maudsley Biomedical Research Centre, Health Informatics is one of the three founding partners behind ‘Rosalind’, a shared, high performance computing facility launched in October 2015. Rosalind provides researchers with a flexible, private cloud environment, alongside traditional compute facilities for bioinformatics, clinical informatics, imaging, sequencing and genomics, supporting next generation, large-scale analyses that will accelerate translational research across the biomedical, life sciences, and health informatics disciplines.
The Precision Health Informatics Data Lab group, led by Professor Richard Dobson, is motivated towards enabling a “panoramic” view of patients that is precise, predictive, preventative and participatory, through the integration of traditional ‘omics data with data derived from mHealth, electronic patient records, knowledge graphs. The group works closely alongside the National Institute for Health Research Maudsley Biomedical Research Centre (NIHR Maudsley BRC) supporting their translational research into novel tests, treatments and technologies to understand and treat mental disorders.
Duration: 12 months full-time/24 months part-time. September to September
This course has been created to deliver a skill set and knowledge base in “multimodal” and “big data” analysis techniques.