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Surface Potential Quantification Engine

SPiQE is the brainchild of a collaboration between neurologists at King’s College London and bioengineers at Imperial College London. It combines the very latest in surface electrode technology with sophisticated spike-detection software. SPiQE functions as an automated analytical pipeline for the detection of spontaneous and voluntary muscle activity. It is non-invasive and well-tolerated by patients. Importantly, this means muscle recordings can be longer than ever before and can be repeated at regular time intervals.

In our Clinical Trials so far, we have focussed on the analysis of fasciculations in motor neuron disease to learn more about this devastating illness.

The project was conceived in 2015 by Professors Chris Shaw (King’s), Kerry Mills (King’s), Martyn Boutelle (Imperial) and Manos Drakakis (Imperial).

PhD students Dr James Bashford (King’s) and Mr Aidan Wickham (Imperial) have helped turn those early ideas into reality. Masters students Urooba Masood, Cristina Cabassi and Domen Planinc as well as junior doctors Dr Tom Weddell and Dr Arina Tamborska are the most recent additions to the team. We have so far collaborated with several groups, including Dr Emma Hodson-Tole (Manchester Metropolitan University) and Professor Ping Zhou (University of Texas).


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Our funders and sponsors

The Neuroscience division at King's houses the clinical expertise for the SPiQE study program. We also work with these sponsors: