Subject areas:
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Funding type:
Study costs.
Awarding body:
Psychiatry Research Trust.
PD facets have different drivers & mediators. We will fill in layers in aetiopathogenic model building, with particular respect to the gut microbiome.
Award details
Background
This is a clinic to laboratory approach.
Aim is to pinpoint an individual’s position within an aetiopathogenic model for potential drivers and mediators, predict their trajectory, and recognise opportunities for (and consequences of) disease-modifying intervention. Interventional studies are being planned to allow the move from association to cause effect.
It is envisaged that incorporating faecal mycobiome and protozome into existing bacteriome data set will be high on agenda in the gut microbiome study.
- Augustin A, et al. Faecal metabolite deficit, gut inflammation and diet in Parkinson's disease: Integrative analysis indicates inflammatory response syndrome. Clin Transl Med. 2023 Jan;13(1):e1152.
- Wang W, et al. Bradyphrenia and Tachyphrenia in Idiopathic Parkinsonism Appear, in Part, Iatrogenic: An Observational Study with Systematic Review Background. J Clin Med. 2023 Oct 12;12(20):6499.
- Wang, W., et al. Non-Helicobacter pylori Helicobacters, a Treatable Provocateur of Parkinson's Disease: Hypothesis, Evidence and Species Specificity. Int J Mol Sci. 2024 Dec 6;25(23):13123.
Umamahesan C, et al. Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson's disease: hypothesis with supportive data. Biochem J. 2025 Jun 11;482(12):807–21.
Award value
Tuition fees and consumables for four years.
Eligibility criteria
Current King's College London MSc or completed MSc course and awaiting award
Application process
Initially email sylvia.dobbs@kcl.ac.uk with CV: subject: PhD application.
Submit formal application via the King’s Apply portal (apply.kcl.ac.uk), selecting the course name: Life Course Science Research MPhil/PhD (Full-time).
Details of what is required and entry requirements etc are here: https://www.kcl.ac.uk/study/postgraduate-research/areas/cancer-and-pharmaceutical-sciences-mphil-phd