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Addictions Department Staff

Professor Ian Stolerman

Emeritus Professor of Behavioural Pharmacology

BPharm, PhD

ProfessorIanStolermanIan Stolerman received a PhD in Psychopharmacology at University College London in 1969. This was followed by postdoctoral experience at the Albert Einstein College of Medicine (NY) and the University of California, Los Angeles. He then forsake the sun for the delights of Birmingham and became a member of the MRC Neuropharmacology Unit. In 1980 he relocated to the Institute of Psychiatry, London as a member of the MRC External Scientific Staff. He headed the Section of Behavioural Pharmacology from 1988 and was Chair of the Institute of Psychiatry’s Interdisciplinary Research Group in Addictions from 2004-2007.

The behavioural analysis of drug dependence has been Ian Stolerman’s major research activity. He has studied a variety of drugs including opiates, psychomotor stimulants, benzodiazepines and alcohol but is best known for research on nicotine dependence on which he has worked for over 30 years. In early studies he obtained evidence that people smoked tobacco to obtain the effects of nicotine and that nicotine was an addictive drug. Subsequent work examined the receptor mechanisms and brain sites through which nicotine acts to bring about dependence and the neurotransmitters involved in mediating its actions downstream from nicotinic receptors. Recent studies have focused on (1) the abiliy of nicotine to enhance cognition in an animal model for assessing attention and (2) on the effects of prenatal exposure to nicotine on the maturation and development of the offspring and on their behaviour during adolescence and adulthood. Another important line of work led to advances in drug discrimination methodology and the first systematic studies of the discrimination of abused drug mixtures.

Teaching activities were mainly contributions to postgraduate courses in Neuroscience and Addictions, and the supervision of MSc and PhD projects. Ian Stolerman also established and managed the Institute-wide Personal Tutor scheme for MPhil/PhD students from its inception up to September 2009.

As part of his efforts to raise the profile of the discipline of behavioural pharmacology, Ian Stolerman was a founder of the European Behavioural Pharmacology Society and became its first chairperson (President) in 1986. From 1992 to 2005 he was Co-Editor of the journal Drug and Alcohol Dependence and served as President of the International Society of Addiction Journal Editors for 2004-2006. He is now Editor-in-Chief of the Encyclopedia of Psychopharmacology which is scheduled for publication by Springer-Verlag in 2010. Awards have included the Meritorious Service Award of the College on Problems of Drug Dependence (USA), Excellence in International Leadership award of the US National Institute on Drug Abuse, and Distinguished Achievement Award of the European Behavioural Pharmacology Society.

Note: Professor Stolerman has retired from his role as a supervisor for PhD students and postdoctoral research workers.

Teaching activities were mainly contributions to postgraduate courses in Neuroscience and Addictions, and the supervision of MSc and PhD projects. Ian Stolerman also established and managed the Institute-wide Personal Tutor scheme for MPhil/PhD students from its inception up to September 2009. No regular teaching activity at the present time.

Publications

Schneider T, Bizarro L, Asherson PJE, Stolerman IP (2012) Hyperactivity, increased nicotine consumption and impaired performance in the 5-choice serial reaction time task in adolescent rats prenatally exposed to nicotine. Psychopharmacology 223: 401-15

Quarta D, Naylor CG, Glennon J, Stolerman IP (2011) Serotonin antagonists in the 5-choice serial reaction time task and their interactions with nicotine. Behavioural Pharmacology 23: 143-152.

Hahn B, Shoaib M, Stolerman IP (2011) Selective nicotinic receptor antagonists: effects on attention and nicotine-induced attentional enhancement. Psychopharmacology 22: 415-429.

Stolerman IP, Childs E, Ford MM, Grant KA (2011) The role of training dose in drug discrimination: a review. Behavioural Pharmacology 22: 415-429.

Stolerman IP (2011) The discrimination of drug mixtures. In: Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies. Glennon RA, Young R, eds. John Wiley & Sons, New Jersey. Pp. 323-359.

Schneider T, Ilott, N, Brolese G, Bizarro L, Asherson PJE, Stolerman IP (2011) Prenatal exposure to nicotine impairs performance of the 5-choice serial reaction time task in adult rats. Neuro­psychopharmacology 36: 1114-1125.

Stolerman IP, Editor-in-Chief (2010) Encyclopedia of Psychopharmacology. Springer-Verlag, Heidelberg.

Schneider T, Bizarro L, Asherson PJE, Stolerman IP (2010) Gestational exposure to nicotine in drinking water: teratogenic effects and methodological issues. Behavioural Pharmacology 21: 206–216.

Smith JW, Stolerman IP (2009) Recognising nicotine: the neurobiological basis of nicotine discrimination. In: Handbook of Psychopharmacology, vol 192, Nicotine Psychopharmacology. Henningfield JE, London ED, Pogun S, eds. Springer-Verlag, Berlin. Pp. 295-333.

Stolerman IP, Naylor CG, Mesdaghinia A, Morris HV (2009) The duration of nicotine-induced attentional enhancement in the 5-choice serial reaction time task: lack of long-lasting cognitive improvement. Behavioural Pharmacology 20: 742-754.

Quarta D, Naylor CG, Barik J, Fernandes C, Wonnacott S, Stolerman IP (2008) Drug discrimination and neurochemical studies in alpha7 null mutant mice: tests for the role of nicotinic alpha7 receptors in dopamine release. Psychopharmacology 203: 399-410.

Stolerman IP (2008) Preparing manuscripts and responding to referees’ reports: inside the editorial black box. In: Publishing Addiction Science: a Guide for the Perplexed. Babor TF, Stenius K, Savva S, O’Reilly J, eds. 2nd edition, ISAJE/SSA co-publication, Multi-Science Publishing Company Ltd, UK. Pp. 124-137.

Stolerman IP, Stenius K (2007) The language barrier and institutional provincialism. Drug and Alcohol Dependence 92: 1-2 (editorial).

Quarta D, Naylor CG, Morris HV, Patel S, Genn RF, Stolerman IP (2007) Different effects of ionotropic and metabotropic glutamate receptor antagonists on attention and the attentional properties of nicotine. Neuropharmacology 53: 421-30.

Semenova S, Stolerman IP, Markou A. (2007) Chronic nicotine administration improves attention while nicotine withdrawal induces performance deficits in the 5-choice serial reaction time task in rats. Pharmacology Biochemistry & Behavior, 87: 360-368.

Matta SG, Balfour DJK, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, Lukas RJ, Markou A, Marks MJ, McCallum SE, Parameswaran N, Perkins KA, Picciotto MR, Quik M, Rose JE, Rothenfluh A, Schafer WR, Stolerman IP, Tyndale RF, Wehner JM, Zirger JM (2007) Guidelines on nicotine dose selection for in vivo research. Psychopharmacology 190, 269-319.

Quarta D, Naylor CG, Stolerman IP (2007) The serotonin2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination. Psychopharmacology 193: 391-402.

Hoyle E, Genn R, Fernandes C, Stolerman IP (2006) Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology 189: 211-223.

Childs E, Shoaib M, Stolerman IP (2006) Cocaine self-administration in rats with histories of cocaine exposure and discrimination. Psychopharmacology 186: 168-176.

Patel S, Stolerman IP, Asherson P, Sluyter F (2006) Attentional Performance of C57BL/6 and DBA/2 mice in the 5-choice serial reaction time task. Behavioural Brain Research 170: 197-203.

Hahn B, Stolerman IP (2005) Modulation of nicotine-induced attentional enhancement in rats by adrenoceptor antagonists. Psychopharmacology 177: 438-447.

Naylor C, Quarta D, Fernandes C, Stolerman IP (2005) Tolerance to nicotine in mice lacking alpha7 nicotinic receptors. Psychopharmacology 180: 558-563.

Bizarro L, Patel B, Murtagh C, Stolerman IP (2004) Differential effects of psychomotor stimulants on attentional performance in rats: nicotine, amphetamine, caffeine and methylphenidate. Behavioural Pharmacology 15: 195-206.

Stolerman IP, Chamberlain S, Bizarro L, Fernandes C, Schalkwyk L. (2004) The role of nicotinic receptor alpha-7 subunits in nicotine discrimination. Neuropharmacology 46: 363-371.

Bizarro L, Patel S, Stolerman IP (2003) Comprehensive deficits in performance of an attentional task produced by co-administering alcohol and nicotine to rats. Drug and Alcohol Dependence 72: 287-295.

Bizarro L, Stolerman IP (2003) Attentional effects of nicotine and amphetamine in rats at different levels of motivation. Psychopharmacology 170: 271-277.

Hahn B, Shoaib M, Stolerman IP (2003) Involvement of the prefrontal cortex but not the dorsal hippocampus in the attention-enhancing effects of nicotine in rats. Psychopharmacology 168: 271-279.

Hahn B, Sharpless CGV, Wonnacott S, Shoaib M, Stolerman IP (2003) Attentional effects of nicotinic agonists in rats. Neuropharmacology 44: 1054-1067.

Stolerman IP, Mariathasan EA (2003) Nicotine trace discrimination in rats with midazolam as a mediating stimulus. Behavioural Pharmacology 14: 55-66.

Hahn B, Shoaib, M, Stolerman IP (2002) Effects of dopamine receptor antagonists on nicotine-induced attentional enhancement. Behavioural Pharmacology 13: 621-632

Stolerman IP (2002) Hits and misses in nicotine psychopharmacology: a personal view of research over a period of 30 years. Nicotine & Tobacco Research 4, 389-394

Lowe AS, Williams SCR, Symms MR, Stolerman IP, Shoaib M (2002) Functional magnetic resonance neuroimaging of drug dependence: naloxone-precipitated morphine withdrawal. Neuroimage 17: 902-910

Hahn B, Stolerman IP (2002) Nicotine-induced attentional enhancement in rats: effects of chronic exposure to nicotine. Neuropsychopharmacology 27: 712-722

Hahn B, Shoaib, M, Stolerman IP (2002) Nicotine-induced enhancement of attention in the five-choice serial reaction time task: the influence of task-demands. Psychopharmacology 162: 129-137

Shoaib M, Gommans J, Morley A, Stolerman IP, Grailhe R, Changeux J-P (2002) The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion. Neuropharmacology 42: 530-539

Stolerman IP, Childs E, Hahn B, Morley A (2002) Drug trace discrimination with nicotine and morphine in rats. Behavioural Pharmacology 13: 49-58

Stolerman IP, Olufsen K (2001) Generalisation of ethanol with drug mixtures containing a positive modulator of the GABAA receptor and an NMDA antagonist. Neuropharmacology 40: 123-130

Stolerman IP, Olufsen K (2000) Influence of training history on ethanol discrimination in rats. Behavioural Pharmacology 11: 603-612

Hahn B, Stolerman IP, Shoaib M (2000) Kappa-opioid receptor modulation of nicotine-induced behaviour. Neuropharmacology 39: 2848-2855

Gommans J, Stolerman IP, Shoaib M (2000) Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice. Neuropharmacology 39: 2840-2847

Zubaran C, Shoaib M, Stolerman IP (2000) The development and expression of locomotor sensitisation to nicotine in the presence of ibogaine. Behav Pharmacol 11: 431-436

Mirza NR, Stolerman IP (2000) The role of nicotinic and muscarinic acetylcholine receptors in attention. Psychopharmacology 148: 243-250

Shoaib M, Zubaran C, Stolerman IP (2000) Antagonism of stimulus properties of nicotine by dihydro-ß-erythroidine (DHßE) in rats. Psychopharmacology 149: 140-146


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