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Drug Control Centre

Selected publications

DCC Publications 2009-2019

 

2019

Viljanto MJ, Kicman AT, Walker CJ, Parkin MC, Wolff K, Pearce CM, Scarth J. Elucidation of the biosynthetic pathways of boldenone in the equine testis. Steroids. 2019 Jun; 146:79-91. doi: 10.1016/j.steroids.2019.03.011. Epub 2019 Apr 2.

I. Gavrilović, D. A. Cowan, A. Woffendin, A. Smart, F. Gong, D. Harding, K. Wolff. Artificial Oral Fluid Characterisation: potential for use as a reference matrix in drug testing. 2019. Submitted to Journal of Analytical Toxicology

Castrignanò, E., Devey, S., Brailsford, A., Wolff, K. (accepted-August 2019).  Monitoring drugs in sport testing: an insight of current trends and recent findings from the Drug Control Centre, the UK’s Anti-Doping Laboratory. Chromatography today.

 

2018

Viljanto M, Pita CH, Scarth J, Walker CJ, Kicman AT, Parkin MC Important considerations for the utilisation of methanolysis in steroid analysis. Drug Test Anal. 2018 Sep; 10(9):1469-1473. doi: 10.1002/dta.2402.

Epub 2018 Jun 14.

Viljanto M, Hincks P, Hillyer L, Cawley A, Suann C, Noble G, Walker CJ, Parkin MC, Kicman AT, Scarth J.  Drug Monitoring dehydroepiandrosterone (DHEA) in the urine of Thoroughbred geldings for doping control purposes. Drug Test Anal. 2018 Oct; 10 (10):1518-1527. doi: 10.1002/dta.2411. Epub 2018 Jun 21.

Moncrieffe D, Parkin MC, Cowan DA. Peptide selection for the quantification of P‐III‐NP in human serum by mass spectrometry. Rapid Commun Mass Spectrom. 2018; 32(7):535-42.

AD Brailsford, WNM Majidin, N Wojek, DA Cowan, C Walker. IRMS delta values (13C) of nandrolone and testosterone products available in the UK: Implications for anti‐doping. (2018) Drug testing and analysis 10 (11-12), 1722-17271

 

2017

Brailsford AD, Bartlett C, Kicman AT, Cowan DA. Increases in Serum Growth Hormone Concentrations Associated with GHB Administration. J Anal Toxicol. 2017 Jan; 41(1):54-59. doi: 10.1093/jat/bkw107.

Viljanto M, Scarth J, Hincks P, Hillyer L, Cawley A, Suann C, Noble G, Walker CJ, Kicman AT, Parkin MC.  Application of testosterone to epitestosterone ratio to horse urine - a complementary approach to detect the administrations of testosterone and its pro-drugs in Thoroughbred geldings. Drug Test Anal. 2017 Sep; 9(9):1328-1336. doi: 10.1002/dta.2109. Epub 2016 Nov 11.

Wang M, Shen J, Liu X, Deng Y, Li J, Finch E, Wolff K.  (2017) J Reliability and Validity of the Treatment Outcome Profile among Patients Attending Methadone Maintenance Treatment Programs in Kunming, China. Substance Abuse Treatment, 77: 89-94

Altamimi MJ, Wolff K,Martin GP,Royall PG. (2017).  An investigation of the anomeric stability of lactose powder stored under high stress conditions. Pharm Tech 29; 3:28-34

Young. S, González. RA, Wolff K, Xenitidis. K, Mutch. L, Malet-Lambert. I, Gudjonsson GH. (2017) Transitions and motivations for substance misuse in prison inmates with ADHD and conduct disorder: Validation of a new instrument. J Dual Diagnosis, 13(2):91-100. doi: 10.1080/ 15504263 .2017.1290859. Epub 2017 Apr 18 

Young S, Gonzalez R, Wolff K, Xenitidis K, Mutch L, Mallet-Lambert I, Gudjonsson G H. Substance and Alcohol Misuse, Drug Pathways, and Offending Behaviours in Association with ADHD in Prison Inmates. (2017) J Attention Disorders 2017 Jan 1:1087054716688532. doi: 10.1177/1087054716688532. [Epub ahead of print]

M Palomino-Schätzlein, AD Brailsford, T Parella, M Pérez-Trujillo. Response to Comment on “Direct Monitoring of Exogenous γ-Hydroxybutyric Acid in Body Fluids by NMR Spectroscopy”: Several Issues to Consider When Quantifying γ-Hydroxybutyric … Analytical chemistry 90 (1), 1046-1047

M Palomino-Schätzlein, Y Wang, AD Brailsford, T Parella, DA Cowan, ... (2017) Direct monitoring of exogenous γ-hydroxybutyric acid in body fluids by nmr spectroscopy. Analytical chemistry 89 (16),       8343-8350

KL Arthur, MA Turner, AD Brailsford, AT Kicman, DA Cowan, JC Reynolds ... Rapid analysis of anabolic steroid metabolites in urine by combining field asymmetric waveform ion mobility spectrometry with liquid chromatography and mass spectrometry. (2017) Analytical chemistry 89 (14), 7431-7437

Castrignanò E., Yang, Z., Bade, R., Baz-Lomba, J. A., Castiglioni, S., Causanilles, A. ,Covaci A., Gracia-Lor E., Hernandez F., Kinyua J., McCall A.-K., van Nuijs A.L.N., Ort C.,Plósz B. G, Ramin P., Rousis N. I, Ryu Y., Thomas K. V, de Voogt P., Zuccato E., Kasprzyk-Hordern, B. Enantiomeric profiling of chiral illicit drugs in a pan-European study (2017) Water Research.

Castrignanò E., Mardal, M., Rydevik, A., Miserez, B., Ramsey, J., Shine, T., Pantoș G. D., Meyer M.R., Kasprzyk-Hordern, B. A new approach towards biomarker selection in estimation of human exposure to chiral chemicals: a case study of mephedrone. 2017). Scientific Reports, 7

Rousis, N. I., Gracia-Lor, E., Zuccato, E., Bade, R., Baz Lomba, J. A., Castrignanò E., Causanilles, A., Covaci A., de Voogt P., Hernàndez F., Kasprzyk-Hordern B., Kinyua J., McCall A.-K., Plósz B. G, Ramin P., Ryu Y., Thomas K. V, van Nuijs A., Yang Z., Castiglioni, S. Wastewater-based epidemiology to assess pan-European pesticide exposure. (2017). Water Research, 121,270-279.

Gracia-Lor, E., Rousis, N. I., Zuccato, E., Bade, R., Baz Lomba, J. A., Castrignanò E., Causanilles A., Hernández F., Kasprzyk-Hordern B., Kinyua J., McCall A.-K., van Nuijs A.L.N., Plósz B. G, Ramin P., Ryu Y., Santos M.M., Thomas K.V., de Voogt P., Yang Z., Castiglioni, S. Estimation of caffeine intake from analysis of caffeine metabolites in wastewater.                 (2017). Science of the Total Environment, 609, 1582-1588.

Gracia-Lor, E., Castiglioni, S., Bade, R., Been, F., Castrignanò E., Covaci, A., González-Mariño I., Hapeshi E., Kasprzyk-Hordern B., Kinyua J., Lai F. Y., Letzel T., Lopardo L., Meyer M. R., O'Brien J., Ramin P., Rousis N. I., Rydevik A., Ryu Y., Santos M. M., Senta I., Thomaidis N. S., Veloutsou S., Yang Z., Zuccato E.,Bijlsma, L. Measuring biomarkers in wastewater as a new source of epidemiological information: Current state and future perspectives. (2017). Environment International, 99, 131-150.

 

2016

Ali K, Rosser T, Bhat R, Wolff K, Hannam S, Rafferty GF, Greenough A Antenatalsmokingand substance-misuse, infant and new-bornresponse to hypoxia. (2016)  Pediatr Pulmonol. 2016 Oct 10. doi:10.1002/ppul.23620. [Epub ahead of print]

Ali K, Rosser T, Bhat R, Wolff K, Hannam S, Rafferty GF, Greenough A. Ventilatory responses to hypercarbia in infants of smoking and substance-misusing mothers. (2016) J Pediatrics (Clinical Laboratory Observation).  May 20. doi: 10.1016/j.jpeds .2016.04.078. [Epub ahead of print]

Ali K, Rossor T, Bhat R, Wolff K, Hannam S, Rafferty GF, Peacock JL,Greenough AAntenatal substance misuse and smoking and new-born hypoxic challenge response. (2016) Arch Dis Child Fetal Neonatal Ed.101:F143-8 doi: 10.1136/archdischild-2015-308491.

A. T. Kicman, D. A. Cowan and I. Gavrilović. Current issues in human sport drug testing: clenbuterol, erythropoietin and xenon in forensic toxicology: drug use and misuse.2016. Royal Society of Chemistry; editors: Susannah Davies, Atholl Johnston, David Holt.

Bade, R., Bijlsma, L., Sancho, J.    V., Baz Lomba, J. A., Castiglioni, S., Castrignanò E., Causanilles A., Gracia-Lor E., Kasprzyk-Hordern B., Kinyua J., McCall A.-K., van Nuijs A.L.N., Ort C., Plósz B. G, Ramin P., Rousis N. I, Ryu Y., Thomas K. V, de Voogt P., Zuccato E., Hernández, F. Liquid chromatography-tandem mass spectrometry determination of synthetic cathinones and phenethylamines in influent wastewater of eight European cities. (2017). Chemosphere, 168, 1032-1041.              

Ryu, Y., Gracia-Lor, E., Bade, R., Baz-Lomba, J. A., Bramness, J. G., Castiglioni, S., Castrignanò E., Causanilles A., Covaci A., De Voogt P., Hernandez F., Kasprzyk-Hordern B., Kinyua J., McCall A.-K., Ort C., Plósz B. G, Ramin P., Rousis N. I., Reid M. J, Thomas, K. V. Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use. (2016). Scientific Reports, 6, [39055].

Baz Lomba, J. A., Salvatore, S., Gracia-Lor, E., Bade, R., Castiglioni, S., Castrignanò E., Causanilles A., Hernandez F., Kasprzyk-Hordern B., Kinyua J., McCall A.-K., van Nuijs A.L.N., Ort C., Plósz B. G, Ramin P., Reid M. J., Rousis N. I, Ryu Y., de Voogt P., Bramness J., Thomas, K. V. Comparison of pharmaceutical, illicit drug, alcohol, nicotine and caffeine levels in            wastewater with sale, seizure and consumption data for 8 European cities. (2016). BMC Public Health, 16, 1035-1046.

Gonzalez-Marino I., Gracia-Lor E., Rousis N., Castrignanò E., Thomas K., Quintana J.B., Kasprzyk-Hordern B., Zuccato E., Castiglioni S. Wastewater-based epidemiology to monitor synthetic cathinones use in different European countries. (2016) Environmental Science & Technology.

Castrignanò E., Lubben A., Kasprzyk-Hordern B. Enantiomeric profiling of chiral drug biomarkers in wastewater with the usage of chiral liquid chromatography coupled with tandem mass spectrometry.(2016)... Journal of Chromatography A, 1438:84-99.

Yang Z., Castrignanò E., Estrela P., Frost C.G. & Kasprzyk-Hordern B. Community Sewage Sensors towards Evaluation of Drug Use Trends: Detection of Cocaine in Wastewater with DNA-Directed Immobilization Aptamer Sensors. (2016). Scientific Reports, 6, [21024].

Böhning D, Böhning W, Guha N, Cowan DA, Sönksen PH, Holt RI. BMC Med Res Methodol. Statistical methodology for age-adjustment of the GH-2000 score detecting growth hormone misuse. 2016 Oct 28; 16(1):147. Erratum in: BMC Med Res Methodol. 2016 Nov 28; 16(1):164.

Sonksen PH, Cowan D, Holt RI. Use and misuse of hormones in sport. Lancet Diabetes Endocrinol. 2016 Nov; 4(11):882-883. doi: 10.1016/S2213-8587(16)30218-2. Epub 2016 Aug 16.

Viljanto M, Scarth J, Hincks P, Hillyer L, Cawley A, Suann C, Noble G, Walker CJ, Kicman AT, Parkin MC. Application of testosterone to epitestosterone ratio to horse urine - a complementary approach to detect the administrations of testosterone and its pro-drugs in Thoroughbred geldings. Drug Test Anal. 2016 Oct 7. doi: 10.1002/dta.2109.

Holt RI, Guha N, Böhning W, Bartlett C, Cowan DA, Sönksen PH, Böhning D. Novel markers to detect recombinant human insulin-like growth factor-I (rhIGF-I)/rhIGF binding protein-3 (rhIGFBP-3) misuse in athletes. Drug Test Anal. 2017 Jan; 9(1):30-37. doi: 10.1002/dta.1941. Epub 2016 Feb 17.

Wang Y, Caldwell R, Cowan DA, Legido-Quigley C. LC-MS-Based Metabolomics Discovers Purine Endogenous Associations with Low-Dose Salbutamol in Urine Collected for Antidoping Tests. Anal Chem. 2016 Feb 16; 88(4):2243-9. doi: 10.1021/acs.analchem.5b03927.

Mick I, Myers J, Ramos AC, Stokes PR, Erritzoe D, Colasanti A, Gunn RN, Rabiner EA, Searle GE, Waldman AD, Parkin MC, Brailsford AD, Galduróz JC, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes AR. Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers. Neuropsychopharmacology. 2016 Jun; 41(7):1742-50. doi: 10.1038/npp.2015.340.

Baume N, Geyer H, Vouillamoz M, Grisdale R, Earl M, Aguilera R, Cowan DA, Ericsson M, Gmeiner G, Kwiatkowska D, Kioukia-Fougia N, Molina A, Ruivo J, Segura J, Van Eenoo P, Jan N, Robinson N, Saugy M. Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013. Drug Test Anal. 2016 Jul; 8(7):603-12. doi: 10.1002/dta.1851.

 

2015 

Vella A, Ventura CS, Wolff K (2015). A Demographic Overview of a 10-year Retrospective Study of Substance Misusing Pregnant Women. March 2015 Euro J Obstet & Gynae, 2015 Oct 14:1-5. 

Bailey MJ, Bradshaw R, Francese S, Salter TL, Costa C, Ismail M, P Webb R, Bosman I, Wolff K, de Puit M (2015)   Rapid detection of cocaine, benzoylecgonine and methylecgonine in fingerprints using surface mass spectrometry. Analyst. 2015 May 15. [Epub ahead of print]

Van der Heide S, Garcia Calavia P, Hardwick S, Hudson S, Wolff K, Russell DA. (2015) A competitive enzyme immunoassay for the quantitative detection of cocaine from banknotes and latent finger marks.  Finger-marks Forensic Sci Int.250:1-7. doi: 10.1016/ j.forsciint. 2015. 02.008. Epub 2015

Kimergård A, Walker C, Cowan D. Potent and untested drugs sold as "dietary supplements". BMJ. 2015 Aug 5; 351:h4181. Doi: 10.1136/bmj.h4181.

Devesse L, Syndercombe Court D, Cowan D. Determining the authenticity of athlete urine in doping control by DNA analysis. Drug Test Anal. 2015 Oct; 7(10):912-8. Doi: 10.1002/dta.1785.

Holt RI, Böhning W, Guha N, Bartlett C, Cowan DA, Giraud S, Bassett EE, Sönksen PH, Böhning D. The development of decision limits for the GH-2000 detection methodology using additional insulin-like growth factor-I and amino-terminal pro-peptide of type III collagen assays. Drug Test Anal. 2015 Sep; 7(9):745-55. doi: 10.1002/dta.1772.

Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1, 3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May; 7(5):433-8. doi: 10.1002/dta.1764. Epub 2015 Jan 13.

Abbate V, Kicman AT, Evans-Brown M, McVeigh J, Cowan DA, Wilson C, Coles SJ, Walker CJ. Anabolic steroids detected in bodybuilding dietary supplements - a significant risk to public health. Drug Test Anal. 2015 Jul; 7(7):609-18. doi: 10.1002/dta.1728.

 

2014

Lopes F, Cowan DA, Thevis M, Thomas A, Parkin MC. Quantification of intact human insulin-like growth factor-I in serum by nano-ultrahigh-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2014 Jul 15; 28(13):1426-32. doi: 10.1002/rcm.6908.

Mick I, Myers J, Stokes PR, Erritzoe D, Colasanti A, Bowden-Jones H, Clark L, Gunn RN, Rabiner EA, Searle GE, Waldman AD, Parkin MC, Brailsford AD, Nutt DJ, Lingford-Hughes AR. Amphetamine induced endogenous opioid release in the human brain detected with [¹¹C] carfentanil PET: replication in an independent cohort. Int J Neuropsychopharmacol. 2014 Dec; 17(12):2069-74. doi: 10.1017/S1461145714000704.

Guha N, Erotokritou-Mulligan I, Bartlett C, Nevitt SP, Francis M, Bassett EE, Cowan DA, Sönksen PH, Holt RI. Biochemical markers of insulin-like growth factor-I misuse in athletes: the response of serum IGF-I, procollagen type III amino-terminal propeptide, and the GH-2000 score to the administration of rhIGF-I/rhIGF binding protein-3 complex. J Clin Endocrinol Metab. 2014 Jun; 99(6):2259-68. doi: 10.1210/jc.2013-3897.

Menzies EL, Hudson SC, Dargan PI, Parkin MC, Wood DM, Kicman AT. Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine. Drug Test Anal. 2014 Jun; 6(6):506-15. doi: 10.1002/dta.1541.

 

2013

Musenga A, Cowan DA. Use of ultra-high pressure liquid chromatography coupled to high resolution mass spectrometry for fast screening in high throughput doping control. J Chromatogr A. 2013 May 3; 1288:82-95. doi: 10.1016/j.chroma.2013.03.006.

Lostia AM, Vicente JL, Cowan DA. Measurement of ethyl glucuronide, ethyl sulphate and their ratio in the urine and serum of healthy volunteers after two doses of alcohol. Alcohol 2013 Jan-Feb; 48(1):74-82. doi: 10.1093/alcalc/ags108.

 

2012

Brailsford AD, Cowan DA, Kicman AT. Pharmacokinetic properties of γ-hydroxybutyrate (GHB) in whole blood, serum, and urine. J Anal Toxicol. 2012 Mar; 36(2):88-95. doi: 10.1093/jat/bkr023.

  

2011

Gavrilović I, Mitchell K, Brailsford AD, Cowan DA, Kicman AT, Ansell RJ. A molecularly imprinted receptor for separation of testosterone and epitestosterone, based on a steroidal cross-linker. Steroids. 2011 Apr; 76(5):478-83. doi: 10.1016/j.steroids.2011.01.004.

 

2010

Brailsford AD, Cowan DA, Kicman AT. Urinary γ-hydroxybutyrate concentrations in 1126 female subjects. J Anal Toxicol. 2010 Nov; 34(9):555-61.

Kicman AT. Biochemical and physiological aspects of endogenous androgens. Handb Exp Pharmacol. 2010 ;( 195):25-64. doi: 10.1007/978-3-540-79088-4_2.

 

2009

 Parkin MC, Brailsford AD. Retrospective drug detection in cases of drug-facilitated sexual assault: challenges and perspectives for the forensic toxicologist. Bioanalysis. 2009 Aug; 1(5):1001-13. doi: 10.4155/bio.09.70.

Cowan DA, Bartlett C. Laboratory issues in the implementation of the marker method. Growth Horm IGF Res. 2009 Aug; 19(4):357-60. doi: 10.1016/j.ghir.2009.04.005.

Kicman AT, Cowan DA. Subject-based profiling for the detection of testosterone administration in sport. Drug Test Anal. 2009 Jan; 1(1):22-4. doi: 10.1002/dta.14. 

Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT. Doping in sport: 3. Metabolic conversion of oral norethisterone to urinary 19-norandrosterone. Steroids. 2009 Mar; 74(3):341-9. doi: 10.1016/j.steroids.2008.11.008.

Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT. Doping in sport--2. Quantification of the impurity 19-norandrostenedione in pharmaceutical preparations of norethisterone. Steroids. 2009 Mar; 74(3):335-40. doi: 10.1016/j.steroids.2008.10.006.

Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT. Doping in sport--1. Excretion of 19-norandrosterone by healthy women, including those using contraceptives containing norethisterone. Steroids. 2009 Mar; 74(3):329-34. doi: 10.1016/j.steroids.2008.10.008.

 

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