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Biobank

Introduction

‘Making translational research into infectious diseases easier and faster to perform’

Welcome to the Infectious Diseases BioBank (IDB). We hope that whether you are a patient who has donated samples, a consultant or a medical researcher, you will find these web-pages interesting and informative. The IDB is embedded within the Department of Infectious Diseases at the Guy’s Campus of King’s College London (KCL) and was established in 2007 by a group of doctors and scientists.

We collect and preserve tissues (usually blood samples) from patients with infectious or inflammatory conditions. These collections will make research into infectious diseases easier, more efficient and faster to perform, by enabling the discovery of new facts about diseases which are essential to design new drugs and better treatments. The major collections in the IDB are from patients infected with human immunodeficiency virus (HIV), hepatitis B (HBV) & hepatitis C (HCV) viruses or, with invasive bacteraemias, including methicillin resistant Staphylococcus aureus (MRSA). The IDB also recruits donations from healthy subjects to act as controls and has recently started storing samples from those with inflammatory diseases such as systemic lupus erythematosus (SLE).

The IDB also plays a central role in supporting clinical studies such as the ground-breaking KCL’s human immune response dynamics (HIRD) investigation into the human immune responses which occur following vaccination with the H1N1 ‘swine flu’ vaccine. Blood samples are separated into DNA, plasmas (cell-free blood) and live white blood cells and then frozen to form a comprehensive ‘library’ of samples. Similarly, the IDB also has a central role in a collaborative inter-NIHR cBRC study of HIV. Medical researchers can apply to access samples (complete with anonymized clinical details) as well as all necessary regulatory permissions from the IDB’s Committee.

The IDB is uniquely positioned to perform its task being in an area of London which has very high rates of infections amongst its population and also is physically located in close proximity to major KCL research centres at Guy’s Hospital with direct contact to internationally acclaimed researchers in Immunology and Infection.

Acknowledgements

Funding
The IDB is grateful for funding from the Guy’s and St Thomas’ Charity and subsequently from the National Institute of Health Research’s (NIHR) comprehensive Biomedical Research Centre (cBRC) at Guy’s and St Thomas’ NHS Foundation Trust. The latter funding was made through the ‘Infection and Immunity’ theme headed by Professors M. Peakman and A.Hayday.


Volunteers
The IDB would like to extend its thanks to all patients and volunteers who have donated samples in the past andin the future.


Images
Ms H. Jackmann provided many of the photographs and images of pathogens were obtained from the library of open access images held by the CDC. EM of HIV in IDB logo: Dr. Edwin P. Ewing, Jr.

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