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Biobank

Research Output

The Infectious Diseases Bionbank (IDB) is relatively new and a critical mass of archived samples was only achieved in around 2010. Whilst samples have been provided to researchers since 2007, the output of papers using IDB samples will increase considerably from 2011.

BioBank papers

  1. Williams R, Mant C, Cason J. The Infectious Diseases BioBank at King's College London: archiving samples from patients infected with HIV to facilitate translational research. Retrovirology 2009; 6: 98.
  2. Kozlakidis Z, Cason RJS, Mant C, Cason J. Legal and Ethical issues in BioBanking. Chapter in: Bio-Engineering, in press.
  3. Kozlakidis Z, Mant C, Abdinur F, Cope A, Steiner S, Peakman M, Hayday A, Cason J. Variation of peripheral blood mononuclear cell RNA quality in archived samples. In press  Biopreservation and Biobanking.
  4. Kozlakidis Z, Mant C, Peters B, Post P, Fox J, Philpott-Howard J, Tong W C-Y, Edgeworth J, Peakman M, Malim M, Cason J. How representative are research tissue biobanks of the local populations? Experience of the Infectious Diseases Biobank (IDB) at King’s College London UK. In press Biopreservation and Biobanking.
  5. Zisis Kozlakidis, Robert J.S. Cason, Christine Mant and John Cason. Assessing research applications from human biobanks: balancing personal sovereignty with the common good.Submitted Research Ethics.

BioBank presentations

  1. Mant C, Cason J. HIV sequence evolution in a LTNP patient. Molecular and Cellular Determinants of HIV Pathogenesis (X8). Keystone Conference, Whistler, Canada March 2007
  2. Mant C, Cason J. HIV sequence evolution in patients. September 1st - 5th, 2007,Nürnberg, Germany.
  3. Cason J. The King’s College London Infectious Diseases BioBank. Biobanking Conference 2010 (Pharma-visiongain), London
  4. Mant C, Cason J. HIV sequence evolution. 4th European Congress ofVirology, Lake Como Italy Apr 2010 .

Medical research arising from use of IDB samples

  1. Nath R, Mant C, Luxton J, Hughes G, Raju KS, Shepherd P, Cason J.High risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients. Arthritis Rheum. 2007; 57:619-625.http://onlinelibrary.wiley.com/doi/10.1002/art.22667/pdf
  2. Alvarez R, Reading J, King DF, Hayes M, Easterbrook P, Farzaneh F, Ressler S, Yang F, Rowley D, Vyakarnam A. WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. J Virol. 2008; 82:471-86.
  3. Herdman MT, Wyncoll D, Halligan E, Cliff PR, French G, Edgeworth JD. Clinical application of real-time PCR to screening critically ill and emergency-care surgical patients for methicillin-resistant Staphylococcus aureus: a quantitative analytical study. J Clin Microbiol. 2009 Dec;47(12):4102-8.
  4. Thorborn G, Pomeroy L, Isohanni H, Perry M, Peters B, Vyakarnam A.Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection. PLoS One. 2010; 5:e9254.
  5. Harris SR, Feil EJ, Holden MT, Quail MA, Nickerson EK, Chantratita N, Gardete S, Tavares A, Day N, Lindsay JA, Edgeworth JD, de Lencastre H, Parkhill J, Peacock SJ, Bentley SD. Evolution of MRSA during hospital transmission and intercontinental spread. Science. 2010 Jan 22;327(5964):469-74.
  6. Holden MT, Lindsay JA, Corton C, Quail MA, Cockfield JD, Pathak S, Batra R, Parkhill J, Bentley SD, Edgeworth JDGenome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW). J Bacteriol. 2010; 192:888-92.

Medical research presentations arising from use of IDB samples.

  1. Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, & Annapurna Vyakarnam, Barry Peters, Quality as well as quantity of CD4 controls HIV progression: implications for the clinic, BHIVA Conference, Belfast, 22nd April 2008 ( P119) http://www.aegis.com/conferences/bhiva/2008/BHIVA2008.pdf
  2. Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, & Annapurna Vyakarnam, Barry Peters, Quality as well as quantity of CD4 controls HIV progression: implications for the clinic, Instituite Pasteur, Paris, France Meeting entitled: 25 years of HIV. August 2008. Poster.
  3. Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, Barry Peters & Annapurna Vyakarnam, Novel evidence that enhanced quality of CD4 T regulatory cell function rather than quantity is associated with virus control in HIV-1 infection, Keystone Symposium on: Prevention of HIV/AIDS (X4) and HIV Immunobiology (X3). Keystone Co, USA. March 2009. Poster. Young Investigator Award.
  4. Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, Melissa Perry & Annapurna Vyakarnam, Barry Peters, Novel evidence that enhanced quality of CD4 T regulatory cell function rather than quantity is associated with virus control in HIV, BHIVA Conference, Manchester, 23rd April 2010 (P57).
  5. Vyakarnam A, Reddy SK, Laura P, Jane M, William T P Barry, Cason J, F Pereyra F, Walker B. Plasma Levels of WFDC1/ps20, a Novel Viral Permissivity Factor in CD4 T Lymphocytes, Correlates Directly with CD4 T Cell Count in Chronic HIV-1 Infection CROI, San Fransico 2010.
  6. Hayday A, Cope A, Malim M, Schulz R, Saadeh H, Kozlakidis Z, Cason J, Binda E, Skowera A, Peakman M. Monitoring human immune responses to H1N1 (swine variant) ‘flu vaccination. Federation of Clinical Immunology Societies June 23-26, 2011, FOCIS 2011, Washington, D.C., USA. http://www.focisnet.org/FOCIS
  7. Georgina Thorborn, Laura Pomeroy, Heidi Isohanni, & Annapurna Vyakarnam, Barry Peters, Elevated Treg-mediated Suppressive Potential, but Not Treg:IL-17 Ratio Distinguishes Chronic Asymptomatic Treatment-naïve HIV+ Subjects from Patients Who Progress to Disease, CROI, Boston 2011 (P263). http://retroconference.org/2011/display.asp?page=199

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