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Centre for Clinical Infection and Diagnostics

Publications

Peer reviewed papers (2016)

Douthwaite ST, Walker C, Adams EJ, Mak C, Vecino Ortiz A, Martinez-Alier N, Goldenberg SD. Performance of a Novel Point-of-Care Molecular Assay for Detection of Influenza A and B Viruses and Respiratory Syncytial Virus (Enigma MiniLab) in Children with Acute Respiratory Infection. J Clin Microbiol. 2016 Jan;54(1):212-5.

Tosas Auguet O, Betley JR, Stabler RA, Patel A, Ioannou A, Marbach H, Hearn P, Aryee A, Goldenberg SD, Otter JA, Desai N, Karadag T, Grundy C, Gaunt MW, Cooper BS, Edgeworth JD, Kypraios T. Evidence for Community Transmission of Community-Associated but Not Health-Care-Associated Methicillin-Resistant Staphylococcus Aureus Strains Linked to Social and Material Deprivation: Spatial Analysis of Cross-sectional Data. PLoS Med. 2016 Jan 26;13(1):e1001944. doi: 10.1371/journal.pmed.1001944. eCollection 2016 Jan.

Peer reviewed papers (2015)

Aguado JM, Anttila VJ, Galperine T, Goldenberg SD, Gwynn S, Jenkins D, Norén T, Petrosillo N, Seifert H, Stallmach A, Warren T. Highlighting clinical needs in Clostridium difficile infection: the views of European healthcare professionals at the front line. Jnl Hosp Infect. 2015 Jun 30;90(2):117-25.

Barrett J, Edgeworth J, Wyncoll D. Shortening the course of antibiotic treatment in the intensive care unit. Expert Rev Anti Infect Ther. 2015; 13(4):463-71.

Biswas JS, Patel A, Otter JA, van Kleef E, Goldenberg SD. Contamination of the Hospital Environment from Potential Clostridium difficile Excretors Without Active Infection. Infect Control Hosp Epidemiol. 2015 Aug;36(8):975-7.

Biswas JS, Patel A, Otter JA, Wade P, Newsholme W, van Kleef E, Goldenberg SD. Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin. Jnl Hosp Infect. 2015 Jul 31;90(3):267-70.

Deeny SR, Worby CJ, Tosas Auguet O, Cooper BS, Edgeworth J, Cookson B, Robotham JV. Impact of mupirocin resistance on the transmission and control of healthcare-associated MRSA. J Antimicrob Chemother. 2015; 70(12):3366-78.

Fitzpatrick JM, Biswas JS, Edgeworth JD, Islam J, Jenkins N, Judge R, Lavery AJ, Melzer M, Morris-Jones S, Nsutebu EF, Peters J. Gram-negative bacteraemia; a multi-centre prospective evaluation of empiric antibiotic therapy and outcome in English acute hospitals. Clin Microbiol Infect. 2015 Nov 11.

Goldenberg SD. Faecal microbiota transplantation for recurrent Clostridium difficile infection and beyond: risks and regulation. Jnl Hosp Infect . 2015 Dec 21.

Goldenberg SD, Bacelar M, Brazier P, Bisnauthsing K, Edgeworth JD. A cost benefit analysis of the Luminex xTAG Gastrointestinal Pathogen Panel for detection of infectious gastroenteritis in hospitalised patients. J Infect. 2015; 70(5): 504-11.

Goldenberg SD, Brown S, Edwards L, Gnanarajah D, Howard P, Jenkins D, Nayar D, Pasztor M, Oliver S, Planche T, Sandoe JA. The impact of the introduction of fidaxomicin on the management of Clostridium difficile infection in seven NHS secondary care hospitals in England: a series of local service evaluations. Eur Jnl Clin Micro Infect Dis. 2015:1-9.

Goldenberg SD, Edgeworth JD. The Enigma ML Flu AB-RSV assay: a fully automated molecular test for the rapid detection of influenza A, B and respiratory syncytial viruses in respiratory specimens. Expert Rev Mol Diagn. 2015; 15(1):23-32.

Horn K, Otter JA. Hydrogen peroxide vapor room disinfection and hand hygiene improvements reduce Clostridium difficile infection, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and extended-spectrum β-lactamase. Am Jnl Infect Control. 2015 Dec 1;43(12):1354-6.

Hughes J, Goldenberg SD, Tosas O, Edgeworth JD, Otter JA. Recent emergence of carbapenem-resistant organisms in a low prevalence UK setting in London. Jnl Infect Prevent. 2015 Dec 14:1757177415622693.

Hughes J, Stabler R, Gaunt M, Karadag T, Desai N, Betley J, Ioannou A, Aryee A, Hearn P, Marbach H, Patel A, Otter JA, Edgeworth JD, Tosas Auguet O. Clonal variation in high- and low-level phenotypic and genotypic mupirocin resistance of MRSA isolated in south-east London. J Antimicrob Chemother. 2015; 70(12):3191-9.

Lemmen S, Scheithauer S, Häfner H, Yezli S, Mohr M, Otter JA. Evaluation of hydrogen peroxide vapor for the inactivation of nosocomial pathogens on porous and nonporous surfaces. Am Jnl Infect Control. 2015 Jan 1;43(1):82-5.

Otter JA, Donskey C, Yezli S, Douthwaite S, Goldenberg SD, Weber DJ. Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination. Jnl Hosp Infect. 2015 Oct 3.

Otter JA, Mepham S, Athan B, Mack D, Smith R, Jacobs M, Hopkins S. Terminal decontamination of the Royal Free London's high-level isolation unit after a case of Ebola virus disease using hydrogen peroxide vapor. Am Jnl Infect Control. 2015 Nov 10.

Otter JA, Vickery K, Walker JD, deLancey Pulcini E, Stoodley P, Goldenberg SD, Salkeld JA, Chewins J, Yezli S, Edgeworth JD. Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection. Jnl Hosp Infect. 2015 Jan 31;89(1):16-27.

Ward C, Stocker K, Begum J, Wade P, Ebrahimsa U, Goldenberg SD. Performance evaluation of the Verigene®(Nanosphere) and FilmArray®(BioFire®) molecular assays for identification of causative organisms in bacterial bloodstream infections. Eur Jnl Clin Micro Infect Dis. 2015 Mar 1;34(3):487-96.

Wilson AP, Livermore DM, Otter JA, Warren RE, Jenks P, Enoch DA, Newsholme W, Oppenheim B, Leanord A, McNulty C, Tanner G. Prevention and control of multi-drug-resistant Gram-negative bacteria: recommendations from a Joint Working Party. Jnl Hosp Infect. 2016 Jan 4;92:S1-44.

Peer reviewed papers (2014)

Adams EJ, Ehrlich A, Turner KM, Shah K, Macleod J, Goldenberg S, Meray RK, Pearce V, Horner P. Mapping patient pathways and estimating resource use for point of care versus standard testing and treatment of chlamydia and gonorrhoea in genitourinary medicine clinics in the UK. BMJ Open. 2014 July 23:4(7):e005322.

Edgeworth JD, Chis Ster I, Wyncoll D, Shankar-Hari M, McKenzie CA. Long-term adherence to a 5-day antibiotic course guideline for treatment of intensive care unit associated Gram-negative infections. J Antimicrob Chemother. 2014 Jun;69(6):1688-94

Goldenberg SD, Bisnathsing KN, Patel A, Postulka A, Wyncoll D, Schiff R, French GL. Point-of-Care Testing for Clostridium Difficile Infection: A Real-World Feasibility Study of a Rapid Molecular Test in Two Hospital Settings. Infect Dis Ther. 2014 Sep 10.

Havill NL, Boyce JM, Otter JA. Extended survival of carbapenem-resistant Enterobacteriaceae on dry surfaces. Infect Control Hosp Epidemiol. 2014 Apr;35(4):445-7.

Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect. 2014 Mar;68(3):242-51.

Otter JA, Davies B, Menson E, Klein JL, Watts TL, Kearns AM, Pichon B, Edgeworth JD, French GL. Identification and control of a gentamicin-resistant, meticillin-susceptible Staphylococcus aureus outbreak on a neonatal unit. J Infect Prevent. 2014 May;15(3):104-9.

Turner KM, Round J, Horner P, Macleod J, Goldenberg S, Deol A, Adams EJ. An early evaluation of clinical and economic costs and benefits of implementing point of care NAAT tests for Chlamydia trachomatis and Neisseria gonorrhoea in genitourinary medicine clinics in England. Sex Transm Infect. 2014 Mar;90(2):104-11

Peer reviewed papers (2013)

Halligan E, Edgeworth J, Bisnauthsing K, Bible J, Cliff P, Aarons E, Klein J, Patel A, Goldenberg S. Multiplex molecular testing for management of infectious gastroenteritis in a hospital setting: a comparative diagnostic and clinical utility study. Clin Microbiol Infect 2013. [Epub ahead of print]

Adams EJ, Ehrlich A, Turner KME, Shah K, Macleod J, Goldenberg SD, Pearce V, Horner PJ. What are the clinical and economic costs and benefits of implementing point of care tests for Chlamydia trachomatis and Neisseria gonorrhoea in genitourinary medicine clinics? Sexually Trans Infect 2013. [Epub ahead of print]

Otter JA, Yezli S, Salkeld JAG, French GL. Evidence that contaminated surfaces contribute to the transmission of hospital pathogens and an overview of strategies to address contaminated surfaces in hospital settings. Am J Infect Control 2013;41:S6-S11.

Otter JA, Patel A, Cliff P, Halligan E, Tosas O, Edgeworth JD. Selection for qacA carriage in CC22 but not CC30 MRSA bloodstream infection isolates during a successful institutional infection control programme. J Antimicrob Chemother 2013;68:992-999.

Otter JA, Herdman MT, Williams B, Tosas O, Edgeworth JD, French GL. Low prevalence of meticillin-resistant Staphylococcus aureus carriage at hospital admission: implications for risk factor based vs. universal screening. J Hosp Infect 2013;83:114-121.

Otter JA, Yezli S, Perl TM, Barbut F, French GL. The role of 'no-touch' automated room disinfection systems in infection prevention and control. J Hosp Infect 2013;83:1-13.

Ma Y, Vilanova D, Atalar K, Delfour O, Edgeworth J, Ostermann M, Hernandez-Fuentes M, Razafimahatratra S, Michot B, Persing DH, Ziegler I, Törös B, Mölling P, Olcén P, Beale R, Lord GM. Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis. PLoS ONE 2013 8:e75918.

Vlek ALM, Cooper BS, Kypraios T, Cox A, Edgeworth JD, Auguet OT. Clustering of antimicrobial resistance outbreaks across bacterial species in the intensive care unit. Clin Infect Dis 2013;57:65-76.

Holden MTG, Hsu L-Y, Kurt K, Weinert LA, Mather AE, Harris SR, Strommenger B, Layer F, Witte W, Lencastre H, Skov R, Westh H, Žemličková H, Coombs G, Kearns AM, Hill RLR, Edgeworth JD, Gould I, Gant V, Cooke J, Edwards GF, McAdam PR, Templeton KE, McCann A, Zhou Z, Castillo-Ramírez S, Feil EJ, Hudson LO, Enright MC, Balloux F, Aanensen DM, Spratt BG, Fitzgerald JR, Parkhill J, Achtman M, Bentley SD, Nübel U. A genomic portraiture of the emergence, evolution and global spread of a methicillin resistant Staphylococcus aureus pandemic. Genome Res 2013;23:653-664.

Harrison D, Muskett H, Harvey S, Grieve R, Shahin J, Patel K, Sadique Z, Allen E, Dybowski R, Jit M, Edgeworth J, Kibbler C, Barnes R, Soni N, Rowan K. Development and validation of a risk model for identification of non-neutropenic, critically ill adult patients at high risk of invasive Candida infection: the Fungal Infection Risk Evaluation (FIRE) Study. Health Technol Assess 2013;17:1-156.

Goldenberg SD. Laboratory diagnosis of Clostridium difficile. Lancet Infect Dis 2013;11: 909-911.

Goldenberg SD. Molecular based diagnostics, including future trends. Medicine 2013; 41: 663-666

de Clare Bronsvoort BM, Thumbi SM, Poole EJ, Kiara H, Auguet OT, Handel IG, Jennings A, Conradie I, Mbole-Kariuki MN, Toye PG, Hanotte O, Coetzer JA, Woolhouse ME. Design and descriptive epidemiology of the Infectious Diseases of East African Livestock (IDEAL) project, a longitudinal calf cohort study in western Kenya. BMC Vet Res 2013;9:171.

Lauinger IL, Bible JM, Halligan EP, Bangalore H, Tosas O, Aarons EJ, MacMahon E, Tong CY. Patient characteristics and severity of human rhinovirus infections in children. J Clin Virol 2013;58:220–216.

Peer reviewed papers (2012)

Otter JA. Hospital infection control in 2012: new solutions for old and resurgent problems. J Healthcare Associated Infect 2012;5:68-72.

Otter JA, Yezli S, French GL. The impact of the suspending medium on the susceptibility of meticillin-resistant Staphylococcus aureus to hydrogen peroxide vapour (HPV) decontamination. J Hosp Infect 2012;82:213-215.

Otter JA, French GL. Community-associated meticillin-resistant Staphylococcus aureus: the case for a genotypic definition. J Hosp Infect 2012;81:143-8. [Selected as one of the top 10 papers of the year by the editor: http://www.journalofhospitalinfection.com/content/editors-choice]

Miller CE, Batra R, Copper BS, Patel AK, Klein J, Otter JA, Kypraios T, French GL, Tosas O, Edgeworth JD. An association between bacterial genotype combined with a high-vancomycin minimum inhibitory concentration and risk of endocarditis in methicillin-resistant Staphylococcus aureus bloodstream infection. Clin Infect Dis 2012;54:591-600.

Goldenberg SD, Volpé H, French GL. Clinical negligence, litigation and health-care associated infections. J Hosp Infect 2012;81:156-162.

Goldenberg SD, Patel A, Tucker D, French GL. Lack of enhanced effect of a chlorine dioxide based cleaning regimen on environmental contamination with Clostridium difficile spores. J Hosp Infect 2012;82:64-67.

Pierce KE, Khan H, Mistry R, Goldenberg SD, French GL, Wangh LJ. Rapid detection of sequence variation in Clostridium difficile genes using LATE-PCR with multiple mismatch-tolerant hybridization probes. J Microbiol Methods 2012;91:269-275.

Goldenberg SD, Finn J, Sedudzi E, White J, Tong CYW. Performance of the GeneXpert CT/NG assay compared to that of the Aptima AC2 assay for detection of rectal Chlamydia trachomatis and Neisseria gonorrhoeae by use of residual Aptima samples. J Clin Microbiol 2012;50;3867-3869.

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