Lucie joined Prof. Adrian Hayday’s lab in October 2008 as a BRC fellow after completing her PhD at the German Cancer Research Centre in Heidelberg.
Her projects focus on the interaction of immune cells and
non-immune cells in the gut during steady state and under challenge. Currently
she is investigating when and by which means intraepithelial lymphocytes (IEL)
communicate with intestinal epithelial cells (IEC) to ensure tissue
homeostasis, enable immunosurveillance and initiate immune responses.
Dr Lucie Abeler-Dörner CV
IEL constitute one of the largest T cell compartments in mice and humans and include conventional as well as unconventional T cells. They rapidly undergo apoptosis after isolation and are thus poorly studied and commonly excluded from models of gut immune function. Using a novel culture method previously established in the lab which allows keeping IEL alive and expanding them in culture, this project focuses on intrinsic properties of conventional and unconventional IEL and their interaction with the epithelium.
Btnl1: an immune molecule on epithelial cells (with Mahima Swamy and Anna Bas)
Btnl1 is a member of the butyrophilins-like family of proteins which share homology with skint and B7 molecules. Several family members in mice and humans have been shown to interact with immune cells and are genetically linked to diseases like sarcoidosis and ulcerative colitis. The expression of Btnl1 is restricted to gut epithelial cells where it influences the cross talk of epithelial cells and IEL. The project aims to elucidate the influence of IEL on Btnl1 expression and the consequences for Btnl1 expression for gut immune responses.
RGS1 in human gut (with Deena Gibbons)
RGS1 (regulator of G protein signaling 1) negatively regulates the signal from a specific subset of G protein-coupled receptors, among them several chemokines receptors. Originally studied in the context of B cell migration, its role in T cells was largely ignored since its expression in peripheral T cells is low. In IEL, in contrast, RGS1 is highly expressed and might play a role in retaining T cells in the gut during peripheral immune activation. The project focuses on the influence of RGS1 on T cells migration and its role in T cell-dependent colitis.
Abeler-Dörner L,Swamy M, Williams G, Hayday AC, and Bas A (2011). Butyrophilins: an emerging family of immune regulators. Trends Immunol, in press
Bas A, Swamy M, Abeler-Dörner L, Williams G, Pang DJ, Barbee SD, and Hayday AC (2011). Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes. PNAS 108, 4376-81
Gibbons DL, Abeler-Dörner L*, Raine T*, Hwang IY, Jandke A, Wencker M, Deban L, Rudd CE, Irving PM, Kehrl JH, Hayday AC (2011). Cutting edge: regulator of g protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. J Immunol 187, 2067-71
Kretz CC, Norpo M, Abeler-Dörner L, Linke B, Haust M, Elder L, Krammer PH, Kuhn A (2010). Anti-annexin 1 antibodies: a new diagnostic marker in the serum of patients with discoid lupus erythematosus. Exp Dermatol 19, 919-21.
Schlaman HR, Olsthoorn MM, Harteveld M, Dörner L, Djordjevic MA, Thomas-Oates JE and Spaink HP (2006). The production of species-specific highly unsaturated fatty acyl-containing LCOs from Rhizobium leguminosarum bv. trifolii is stringently regulated by nodD and involves the nodRL genes. Mol Plant Microbe Interact. 19, 215-26.
Spierings E, Vermeulen CJ, Vogt, MH, Dörner L, Falkenburg JHF, Mutis T and Goulmy E (2003). Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation. Lancet 362, 610-15.