Hayday research group
Yasmin Haque, PhD
I first joined the Hayday group in June 2005. My initial studies examined the function of γδ T cells in mammalian models and human ex vivo models. I have also work on projects that study the role of NKG2D/stress ligands and MHCI related molecules in various models of transplantation and skin immunology. Since November 2011 I have been an Industry Sponsored Researcher for ImmunoQure AG. I have determined the in vivo efficacy of several therapeutic antibodies in different models of human disease for patent application.
Olga Sobolev, PhD
Olga joined Professor Adrian Hayday's lab in October 2008. Her research initially focused on understanding the early events in the activation of dendritic epidermal T cells (DETC), a prototypic tissue resident T cell, in response to epithelial stress such as UV irradiation. The aim of this project is to provide a molecular definition of the in vivo lymphoid stress surveillance response. A more recent project is the Human Immune Response Dynamics study. The HIRD study analyzes samples collected from 200 healthy volunteers prior to, and at several time points following, vaccination against H1N1 influenza (swine 'flu), in order to create a better understanding of the normal human immune response to an immunological challenge.
Dr. Pierre Vantourout, PhD
I recently completed my Ph.D in Physiopathology in the INSERM U563 unit in Toulouse, France. I worked on the involvement of Ecto-F1-ATPase, a cell-surface form of the mitochondrial ATP synthase, in phosphoantigen presentation to Vgamma9/Vdelta2 T cells. This work provided a better understanding of the mechanisms driving tumor cell recognition by this major human gamma delta T cell subset.
I joined Professor Hayday’s laboratory in October 2009 as a post-doctoral research fellow. My project will aim to identify the mechanisms regulating the expression of MICA, an MHC-I-like “stress marker” activating cytotoxic lymphoid subpopulations, such as NK or gamma delta T cells, though its recognition by the NKG2D receptor. The functional implications of MICA’s polymorphism, while linked to many autoimmune diseases, are poorly understood thus we also aim to understand why different MICA alleles have different stimulatory potentials.
Robin Dart BSc MRCP
Robin joined the laboratory as a Francis Crick Institute – NIHR Biomedical Research Centre clinical training fellow. He is a gastroenterology registrar with a clinical interest in inflammatory bowel disease and is studying the lymphoid stress surveillance response in the human intestine and its role in health and disease.
Rosie Hart, PhD
Rosie joined Professor Hayday’s lab in November 2011 following the completion of her PhD at Oxford University looking at the contribution of the chemoattractant chemerin to inflammation and a year at Cancer Research UK spent studying the mechanism of action of kindlin-3, a protein involved in the activation of the integrin LFA-1.
Skint-1 is a protein responsible for the selective development of Vgamma5Vdelta1 dendritic epidermal T cell (DETC) progenitors in the thymus. However it is also expressed by keratinocytes. Rosie is investigating whether Skint-1 has a peripheral function in the regulation of DETCs.
Dr Richard Woolf, MBChB, BSc, MRCP
Rick is a Specialist Registrar in Dermatology. He initially joined Professor Hayday’s group as a NIHR-funded Academic Clinical Fellow, and more recently, as an MRC-funded Clinical Research Fellow. Professor Hayday has defined the capacity of lymphocytes to recognise infection or tissue dysregulation (‘stress’) and to respond rapidly in synchrony with an innate response as the lymphoid stress surveillance response (LSSR). The LSSR is particularly relevant to immunosurveillance within epithelial tissues that have large resident lymphocyte populations, as described in mouse skin. Rick is interested in the human skin resident immune compartment. He is investigating if certain lymphocyte subsets have the capacity to respond to tissue stress, within the epidermis or dermis, in an LSSR-compatible way.
Rafael Di Marco Barros, BSc
Rafael joined Professor Hayday’s group in September 2012 as an MB/PhD student from UCL medical school. His undergraduate research project looked at the potential of TCR-gene transfer in adoptive T cell therapy to target EBV-associated Burkitt’s Lymphoma. Now at the immunosurveillance laboratory, he is investigating the response and regulation of tissue-resident T Cells that are believed to be auto-reactive
Yin Wu MRCP PhD
Yin completed his PhD with Dr. Kenth Gustafsson and Dr. Paul Digard investigating the role of innate immunity against influenza A virus. He joined Professor Hayday's lab in 2011, first as an NIHR Academic Foundation Fellow and more recently extending his stay as an NIHR ACF in Medical Oncology. His current work focuses on understanding the role of tumour infiltrating lymphocytes in human breast cancers. This is done in collaboration with Professor Andrew Tutt's group at Breakthrough Breast Cancer. Outside of his time in the labs, Yin likes to see cancer patients on the wards and in clinics.
Maria Luisa Iannitto, PhD
Maria Luisa joined Professor Hayday’s group in 2012 after completing her PhD in Immunology at ‘Sapienza’ University of Rome during which she studied NKG2D and DNAM1 ligand expression in multiple myeloma. She is now investigating the role of the same molecules and their receptors within the Lymphoid Stress Surveillance Response and in the regulation of tissue infiltrating- and tumour infiltrating- γδ T cells.
Adam Laing, PhD
Adam joined Professor Hayday’s Lab in May 2013 to work on the infection, immunity and immunophenotyping (3i) project; a broad immune phenotyping screen of a KO-mouse library in collaboration with the WTSI. Adam’s work has focused on the development of a high-throughput, high-dimensional flow cytometric screen of the mouse immune system and automated analysis of flow data. In addition, Adam is working on a number of mutants identified in the primary screen to further understand the function of these gens in the immune system. Before joining the lab, Adam completed his PhD in the immunology of stem cell transplantation at the MRC Centre for transplantation at KCL.
Dmitry Ushakov, PhD
I completed my Ph.D. in Biochemistry at the University of North Texas Health Science Centre. I worked on development of advanced fluorescence microscopy techniques to investigate the dynamics of cytoskeleton, particularly the molecular mechanisms of myosin and actin binding proteins. I joined Professor Adrian Hayday group in 2013. My current research is directed at understanding the role of T cells in epithelial homeostasis and development of fluorescence microscopy and automated image analysis for immunological phenotyping of mouse epidermis for the Infection, Immunity and Immunophenotyping (3i) consortium, with emphasis on changes in ultrastructure, cytoskeleton, cell number and intercellular contacts of dendritic epidermal T cells and Langerhans cells in tissue.
Deborah Enting, MBBS, MSc, MRCP
Deborah is a Specialist Registrar in Medical Oncology at Guy’s Hospital. She joined Professor Hayday’s group in 2010 as an Academic Clinical Fellow. In 2013 she was awarded an MRC/Prostate Cancer UK Clinical Research Fellowship for her PhD project. She is interested in the function of the lymphoid stress-surveillance response in men with prostate cancer and in particular whether prostate cancer stage and currently used anti-cancer therapies have an influence on this. Together with her colleague Maria Luisa Iannitto, she works on a large immune monitoring project involving many prostate cancer patients in collaboration with the Cancer Epidemiology Group at KCL. Furthermore she is investigating the long term effects of bisphosphonate therapy (often used to treat metastatic bone disease) on immune function and in particular gamma delta T cells.
Fernanda Kyle Cezar, PhD
Fernanda joined Professor Hayday’s lab in February 2012 following the completion of her PhD at the Federal University of Rio de Janeiro. She investigated the physiological role of the multidrug resistance protein (MDR1/Pgp) in the immune system.
Her current work focouses on studing the tumour infiltrating lymphocytes in human breast cancers from a tissue resident lymphocyte perspective. This is done in collaboration with Professor Andrew Tutt's group at Breakthrough Breast Cancer.
Bodhi Hunt, BSc
Bodhi joined the Hayday group as a PhD student in 2010 after completing his undergraduate degree in Genetics at the University of Cambridge. His research focuses on gamma delta T cell dependent immunoglobulin E production downstream of skin immunization. He is carrying out an immunoglobulin repertoire analysis of this response using next generation sequencing in order to elucidate details of its mechanism and possible functionality.
Sean O’Farrell, BSc
Sean obtained his BSc in the subject of Pharmacology from University College Dublin before completing a Master of Research at King’s College London in Translational Medicine, with a focus on Immunology and Epidemiology. He joined Professor Hayday’s group in August 2013 as a full-time PhD student. As part of the Human Immune Response Dynamics (HIRD) team, his research focuses on the identification and validation of novel cellular and molecular mechanisms that may play key roles in human vaccine immunity