Non technical research summary
Professor Hayday’s research focuses on a novel form of immune response that his team has termed “lymphoid stress-surveillance”. In this process, lymphocytes provide a rapid response to infection and to incidences known as “sterile dysregulation”, which is when tissues are subject to physico-chemical damage or irradiation, without the obvious involvement of pathogenic microbes or viruses. The response bolsters tissue integrity during challenge, but if it occurs coincident with infection or exposure to allergens, it may also greatly affect the specific immune responses to those agents. Thus, lymphoid stress-surveillance has implications for tumour immunology, allergy, and vaccination. Moreover, some of its features make it particularly attractive for clinical application. However, this a novel area of Immunobiology, and, as such, is relatively poorly understood.
Reflecting this, Professsor Hayday’s research seeks to identify key molecular processes and mechanisms that regulate lymphoid stress surveillance, particularly via a better understanding of the lymphocytes that mediate it. His research involves some highly international, long-term collaborations, and spans the development of the novel reductionist molecular models to the formulation of clinical trials.
Professsor Hayday’s team is generously supported by peer reviewed funding from the Wellcome Trust and the Medical Research Council, and is part undertaken at the London Research Institute of Cancer Research UK. This support permits us to maintain a laboratory of approximately 27 researchers, currently originating in ten different countries. We are committed to providing outstanding research opportunities for PhD and post-doctoral training.