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Michele Mishto

Michele Mishto

Mishto_photo_Science_2016_small

Michele Mishto, Dr. rer. Nat.

ORCHID:  0000-0003-3042-2792

 

Senior Lecturer in Immunobiology

Email: michele.mishto@kcl.ac.uk

 

 

 

Research interests

Proteasome is the core of the ubiquitin-proteasome system and responsible of the degradation of the majority of the protein in the cytosol. It is therefore involved in a large variety of metabolic pathways, including inflammation and antigen processing and presentation.

Proteasome produces fragments by canonical peptide-bond hydrolysis or by peptide splicing. Indeed, proteasome can break a protein and reshuffle its sequence by combining non-continuous fragments, thereby generating spliced peptides. By peptide splicing, proteasome significantly enlarges the antigenic landscape of a cell. 

 Fig_1We investigate the implications of this mechanism in tumour immunology, autoimmunity and in the CD8+ T cell response during infection, with the long-term aim to improve the efficacy of immunotherapy and vaccine development.

By applying a multi-scale and multi-disciplinary approach – thereby combining in silico, in vitro and in vivo strategies – we also study the ability of proteasome isoforms to regulate the inflammation in the extracellular space by producing peptides with an enhanced ability to promote leucocyte chemotaxis, adhesion, etc.

 

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