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Michele Mishto


Selected Publications:

Platteel ACM, Liepe J, van Eden W, Mishto M, Sijts AJAM. An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes:  Is There Relevance for Vaccine Development? Front Immunol 2017. Nov 3;8:1441. doi: 10.3389/fimmu.2017.01441. PubMed PMID: 29163514. 

Mishto M, Liepe J. Post-translational peptide splicing and T cell response. Trends Imm. 2017. Doi: 10.1016/

Platteel ACM, Liepe J, Textoris-Taube K, Keller C, Henklein P, Schalkwijk HH, Cardoso R, Kloetzel PM, Mishto M*, Sijts AJAM*. Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8(+) T Cells during Bacterial Infection. Cell Rep. 2017 Aug 1;20(5):1242-1253. doi: 10.1016/j.celrep.2017.07.026. PubMed PMID: 28768206. * Authors equally contributed.

Dianzani, C., et al., and M. Mishto. Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis. Sci Rep 2017 Mar 9;7, 43718; doi: 10.1038/srep43718.

Liepe J, Marino F, Sidney J, Jeko A, Bunting DE, Sette A, Kloetzel PM, Stumpf MP, Heck AJ, Mishto M. A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Science 2016 Oct; 354(6310): 354-358. DOI: 10.1126/science.aaf4384.

Ebstein F, et al., and Mishto M. Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes. Sci Rep. 2016 Apr 6;6:24032. doi: 10.1038/srep24032. PubMed PMID: 27049119.

Textoris-Taube K, KellerC, Liepe J, Henklein P, Sidney J, Sette A, Kloetzel PM, Mishto M. The T210M substitution in the HLA-A*02:01 gp100 epitope strongly affects overall proteasomal cleavage site usage and antigen processing. J Biol Chem. 2015 Dec 18;290(51):30417-28. doi: 10.1074/jbc.M115.695189. PMID: 26909514.

Liepe J, Holzhütter HG, Bellavista E, Kloetzel PM, Stumpf MP, Mishto M. Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes. eLife. 2015 Sep 22;4. doi: 10.7554/eLife.07545. PubMed PMID: 26393687


Mishto M, Raza ML, de Biase D, Ravizza T, Vasuri F, Martucci M, Keller C, Bellavista E, Buchholz TJ, Kloetzel PM, Pession A, Vezzani A, Heinemann U. The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy. Brain Behav Immun. 2015 Oct;49:188-96. doi: 10.1016/j.bbi.2015.05.007. PubMed PMID: 26044087.


Mishto M, Goede A, Textoris-Taube K, Keller C, Janek K, Henklein P, Niewienda A, Kloss A, Gohlke S, Dahlmann B, Enenkel C, Kloetzel PM. Driving forces of proteasome-catalyzed peptide splicing in yeast and humans. Mol Cell Proteomics. 2012 Oct;11(10):1008-23. doi: 10.1074/mcp.M112.020164. PubMed PMID: 22822185.


Mishto M, Bellavista E, Santoro A, Stolzing A, Ligorio C, Nacmias B, Spazzafumo L, Chiappelli M, Licastro F, Sorbi S, Pession A, Ohm T, Grune T and Franceschi C. Immunoproteasome and LMP2 polymorphism in aged and Alzheimer’s disease brains. Neurobiology of Ageing 2006 Jan; 27 (1): 54-66. Doi: 10.1016/j.neurobiolaging.2004.12.004. PMID: 16298241.


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