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Timothy Tree



Mannering SI, Wong FS, Durinovic-Bello I, Brooks-Worrell B, Tree TI, Cilio CM, Schloot NC, Mallone R. Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes. Clin Exp Immunol 2010;162:197-209.

Tree TI, Lawson J, Edwards H, Skowera A, Arif S, Roep BO, Peakman M: Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression. Diabetes 59:1451-1460, 2010


Allen JS, Pang K, Skowera A, Ellis R, Rackham C, Lozanoska-Ochser B, Tree T, Leslie RD, Tremble JM, Dayan CM, Peakman M: Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture. Diabetes 58:138-145, 2009

Huurman VA, Velthuis JH, Hilbrands R, Tree TI, Gillard P, van der Meer-Prins PM, Duinkerken G, Pinkse GG, Keymeulen B, Roelen DL, Claas FH, Pipeleers DG, Roep BO: Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation. Am J Transplant 9:382-388, 2009
Skowera A, Ellis RJ, Varela-Calvino R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger W, Drijfhout JW, Ossendorp F, Roep BO, Peakman M: CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 118:3390-3402, 2008
Lawson JM, Tremble J, Dayan C, Beyan H, Leslie RD, Peakman M, Tree TI: Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin Exp Immunol 154:353-359, 2008 

Moss, C.X., Tree, T.I., and Watts, C. 2007. Reconstruction of a pathway of antigen processing and class II MHC peptide capture. EMBO J 26:2137-2147.
Tree, T.I., Roep, B.O., and Peakman, M. 2006. A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop. Ann N Y Acad Sci 1079:9-18.
Pinkse, G.G., Boitard, C., Tree, T.I., Peakman, M., and Roep, B.O. 2006. HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee. Ann N Y Acad Sci


2005 - 2004

Lindley, S., Dayan, C.M., Bishop, A., Roep, B.O., Peakman, M., and Tree, T.I. 2005. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54:92-99.
Ellis, R.J., Varela-Calvino, R., Tree, T.I., and Peakman, M. 2005. HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides. Immunology 116:337-346.
Tree, T.I., Roep, B.O., and Peakman, M. 2004. Enhancing the sensitivity of assays to detect T cell reactivity: the effect of cell separation and cryopreservation media. Ann N Y Acad Sci 1037:26-32.
Tree, T.I., and Peakman, M. 2004. Autoreactive T cells in human type 1 diabetes. Endocrinol Metab Clin North Am 33:113-133, ix-x.
Tree, T.I., Duinkerken, G., Willemen, S., de Vries, R.R., and Roep, B.O. 2004. HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65. Diabetes 53:1692-1699. 

*Tree, T.I., Arif, S., Astill, T.P., Tremble, J.M., Bishop, A.J., Dayan, C.M., Roep, B.O., and Peakman, M. 2004. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest

113:451-463. (* joint 1st author)

2003 - 2000

Schloot, N.C., Meierhoff, G., Karlsson Faresjo, M., Ott, P., Putnam, A., Lehmann, P., Gottlieb, P., Roep, B.O., Peakman, M., and Tree, T. 2003. Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop. J Autoimmun 21:365-376.
*Tree, T.I., Greening, J.E., Kotowicz, K.T., van Halteren, A.G., Roep, B.O., Klein, N.J., and Peakman, M. 2003. Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells. Diabetes 52:717-725. (* joint 1st author)
Astill, T.P., Ellis, R.J., Arif, S., Tree, T.I., and Peakman, M. 2003. Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules. Diabetologia 46:496-503.
Tree, T., Tomlinson, A., Astill, T., Chicz, R.M., Dayan, C.M., and Peakman, M. 2002. Identification of naturally processed and presented glutamic acid decarboxylase-65 epitopes reveals presence of regulatory T cells in non-diabetic individuals. In preparation.
Peakman, M., Tree, T.I., Endl, J., van Endert, P., Atkinson, M.A., and Roep, B.O. 2001. Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes. Diabetes 50:1749-1754.
Tree, T.I., O'Byrne, D., Tremble, J.M., MacFarlane, W.M., Haskins, K., James, R.F., Docherty, K., Hutton, J.C., and Banga, J.P. 2000. Evidence for recognition of novel islet T cell antigens by granule-specific T cell lines from new onset type 1 diabetic patients. Clin Exp Immunol 121:100-105.
Tree, T.I., Morgenthaler, N.G., Duhindan, N., Hicks, K.E., Madec, A.M., Scherbaum, W.A., and Banga, J.P. 2000. Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies. Diabetologia 43:881-889.
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