
Dr Matthias Krause
Senior Lecturer
Research interests
- Biomedical and life sciences
Biography
Dr Matthias Krause is a Senior Lecturer in the Randall Centre for Cell & Molecular Biophysics, School of Basic & Medical Biosciences.
Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes
Redhead, Y., Gibbins, D., Lana-Elola, E., Watson-Scales, S., Dobson, L., Krause, M., Liu, K. J., Fisher, E. M. C., Green, J. B. A. & Tybulewicz, V. L. J., 26 Apr 2023, In: Development (Cambridge). 150, 8, dev201077.Research output: Contribution to journal › Article › peer-review
GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration
Dobson, L., Barrell, W., Seraj, Z., Lynham, S., Wu, S.-Y., Krause, M. & Liu, K., 26 Sept 2023, In: Cell Reports.Research output: Contribution to journal › Article › peer-review
Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR
Moritz, S., Krause, M., Schlatter, J., Cordes, N. & Vehlow, A., 24 Oct 2021, In: Cancers. 13, 21, 5337.Research output: Contribution to journal › Article › peer-review
Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
Krause, M., Stramer, B., Ameer-Beg, S., Poland, S., Levitt, J., Marcotti, S., Köchl, R., Pallett, T., Law, A.-L., Binti Abd Jalal, S. & Mosis, F., 28 Sept 2021, In: Nature Communications. 12, 1, 1 p., 5687.Research output: Contribution to journal › Article › peer-review
Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation
Brazzo, J. A., Biber, J. C., Nimmer, E., Heo, Y., Ying, L., Zhao, R., Lee, K., Krause, M. & Bae, Y., Jun 2021, In: Journal of Cell Science. 134, 12, jcs257709.Research output: Contribution to journal › Article › peer-review
Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation
Dimchev, G., Amiri, B., Humphries, A. C., Schaks, M., Dimchev, V., Stradal, T. E. B., Faix, J., Krause, M., Way, M., Falcke, M. & Rottner, K., 1 Apr 2020, In: Journal of Cell Science. 133, 7, jcs239020.Research output: Contribution to journal › Article › peer-review
Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration: explants for the study of neural crest cell delamination and migration
Gonzalez Malagon, S. G., Dobson, L., Lopez Munoz, A. M., Dawson, M., Barrell, W., Marangos, P., Krause, M. & Liu, K. J., 3 Oct 2019, In: Journal of Visualized Experiments. 152, e60051.Research output: Contribution to journal › Article › peer-review
FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis
Chan Wah Hak, L., Khan, S., Di Meglio, I., Law, A.-L., Lucken-ardjomande Häsler, S., Quintaneiro, L. M., Ferreira, A. P. A., Krause, M., Mcmahon, H. T. & Boucrot, E., Sept 2018, In: Nature Cell Biology. 20, 9, p. 1023-1031Research output: Contribution to journal › Article › peer-review
Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
Gonzalez Malagon, S. G., Lopez Muñoz, A. M., Doro, D., Bolger, T. G., Poon, E., Tucker, E. R., Adel Al-Lami, H., Krause, M., Phiel, C. J., Chesler, L. & Liu, K. J., 19 Mar 2018, (E-pub ahead of print) In: Nature Communications. 9, 1, 15 p., 1126.Research output: Contribution to journal › Article › peer-review
Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
Bodo, C., Fernandes, C. & Krause, M., 1 Dec 2017, In: Scientific Reports. 7, 1, 5365.Research output: Contribution to journal › Article › peer-review
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
Carmona, G., Perera, U., Gillett, C., Naba, A., Law, A.-L., P Sharma, V., Wang, J., Wyckoff, J., Balsamo, M., Mosis, F., De Piano, M., Monypenny, J., Woodman, N., E McConnell, R., Mouneimne, G., Van Hemelrijck, M., Cao, Y., Condeelis, J., O Hynes, R. & Gertler, F. B. & 1 others, Krause, M., 29 Sept 2016, In: Oncogene. 35, p. 5155–5169Research output: Contribution to journal › Article › peer-review
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Krause, M. & Gautreau, A., 1 Sept 2014, In: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 15, p. 577-590 14 p.Research output: Contribution to journal › Literature review › peer-review
Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo
Law, A.-L., Vehlow, A., Kotini, M., Dodgson, L., Soong, D., Theveneau, E., Bodo, C., Taylor, E., Navarro, C., Perera, U., Michael, M., Dunn, G., Bennett, D., Mayor, R. & Krause, M., Nov 2013, In: Journal of Cell Biology. 203, 4, p. 673-689 23 p., N/A.Research output: Contribution to journal › Article › peer-review
Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis
Vehlow, A., Soong, D., Vizcay-Barrena, G., Bodo, C., Law, A.-L., Perera, U. & Krause, M., 27 Sept 2013, In: The EMBO journal. N/A, N/A, p. 1-13 13 p., N/A.Research output: Contribution to journal › Article › peer-review
ABL AT THE LEADING EDGE
Krause, M., 24 Nov 2011, In: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 12, 1Research output: Contribution to journal › Editorial › peer-review
Morphological Differentiation of Neurons on Microtopographic Substrates Fabricated by Rolled-Up Nanotechnology
Schulze, S., Huang, G., Krause, M., Aubyn, D., Quinones, V. A. B., Schmidt, C. K., Mei, Y. & Schmidt, O. G., Sept 2010, In: ADVANCED ENGINEERING MATERIALS. 12, 9, p. B558 - B564Research output: Contribution to journal › Article › peer-review
c-Abl, Lamellipodin, and Ena/VASP Proteins Cooperate in Dorsal Ruffling of Fibroblasts and Axonal Morphogenesis
Michael, M., Vehlow, A., Navarro, C. & Krause, M., 11 May 2010, In: Current Biology. 20, 9, p. 783 - 791 9 p.Research output: Contribution to journal › Article › peer-review
Drosophila Pico and Its Mammalian Ortholog Lamellipodin Activate Serum Response Factor and Promote Cell Proliferation
Lyulcheva, E., Taylor, E., Michael, M., Vehlow, A., Tan, S., Fletcher, A., Krause, M. & Bennett, D., 11 Nov 2008, In: Developmental Cell. 15, 5, p. 680 - 690 11 p.Research output: Contribution to journal › Article › peer-review
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alpha IIb beta 3
Watanabe, N., Bodin, L., Pandey, M., Krause, M., Coughlin, S., Boussiotis, V. A., Ginsberg, M. H. & Shattil, S. J., Jun 2008, In: Journal of Cell Biology. 181, 7, p. 1211 - 1222 12 p.Research output: Contribution to journal › Article › peer-review
MIG-10/Lamellipodin and the lipid modulator AGE-1/PI3K promote axon guidance and outgrowth in response to Slit and netrin.
Chang, C., Adler, C. E., Krause, M., Clark, S. G., Gertler, F. B., Tessier-Lavigne, M. & Bargmann, C. I., 9 May 2006, In: Current Biology. 16, 9, p. 854 - 862 9 p.Research output: Contribution to journal › Article › peer-review
Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions
Rottner, K., Krause, M., Gimona, M., Small, J. V. & Wehland, J., 2001, In: Molecular Biology of the Cell. 12, 10, p. 3103 - 3113 11 p.Research output: Contribution to journal › Article › peer-review
The Ena/VASP enigma
Krause, M., Bear, J. E., Loureiro, J. J. & Gertler, F. B., 15 Dec 2002, In: Journal of Cell Science. 115, 24, p. 4721 1 p.Research output: Contribution to journal › Article › peer-review
ENA/VASP proteins: Regulators of the actin cytoskeleton and cell migration (review)
Krause, M., Dent, E. W., Bear, J. E., Loureiro, J. J. & Gertler, F. B., 2003, In: Annual Review of Cell and Developmental Biology. 19, p. 541 - 564 24 p.Research output: Contribution to journal › Article › peer-review
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
Krause, M., Leslie, J. D., Stewart, M., Lafuente, E. M., Valderrama, F., Jagannathan, R., Strasser, G. A., Rubinson, D. A., Liu, H., Way, M., Yaffe, M. B., Boussiotis, V. A. & Gertier, F. B., Oct 2004, In: Developmental Cell. 7, 4, p. 571 - 583 13 p.Research output: Contribution to journal › Article › peer-review
Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis
Coppolino, M. G., Krause, M., Hagendorff, P., Monner, D. A., Trimble, W., Grinstein, S., Wehland, J. & Sechi, A. S., 2001, In: Journal of Cell Science. 114, Pt 23, p. 4307 - 4318 12 p.Research output: Contribution to journal › Article › peer-review
Regulating cellular actin assembly
Bear, J. E., Krause, M. & Gertler, F. B., 1 Apr 2001, In: Current Opinion in Cell Biology. 13, 2, p. 158 1 p.Research output: Contribution to journal › Article › peer-review
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility
Bear, J. E., Svitkina, T. M., Krause, M., Schafer, D. A., Loureiro, J. J., Strasser, G. A., Maly, I. V., Chaga, O. Y., Cooper, J. A., Borisy, G. G. & Gertler, F. B., 17 May 2002, In: Cell. 109, 4, p. 509 - 521 13 p.Research output: Contribution to journal › Article › peer-review
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
Krause, M., Sechi, A. S., Konradt, M., Monner, D., Gertler, F. B. & Wehland, J., 3 Apr 2000, In: Journal of Cell Biology. 149, 1, p. 181 1 p.Research output: Contribution to journal › Article › peer-review
RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
Lafuente, E. M., van Puijenbroek, A., Krause, M., Carman, C. V., Freeman, G. J., Berezovskaya, A., Constantine, E., Springer, T. A., Gertier, F. B. & Boussiotis, V. A., Oct 2004, In: Developmental Cell. 7, 4, p. 585 - 595 11 p.Research output: Contribution to journal › Article › peer-review
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1
Lebrand, C., Dent, E. W., Strasser, G. A., Lanier, L. M., Krause, M., Svitkina, T. M., Borisy, G. G. & Gertler, F. B., 8 Apr 2004, In: Neuron. 42, 1, p. 37 - 49 13 p.Research output: Contribution to journal › Article › peer-review
Functional antagonism between Ena/VASP proteins and capping activity in the lamellipodia
Bear, J. E., Svitkina, T. M., Krause, M., Schafer, D., Loureiro, J. J., Strasser, G. A., Cooper, J. A., Borisy, G. & Gertler, F. B., 2001, In: Molecular Biology of the Cell. 12, p. 396A - 396AResearch output: Contribution to journal › Meeting abstract
Lamellipodin, a novel Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
Krause, M., Leslie, J. D., Stewart, M., Lafuente, E. M., Valderrama, F., Jagannathan, R., Strasser, G. A., Rubinson, D. A., Liu, H., Way, M., Yaffe, M. B., Boussiotis, V. A. & Gertler, F. B., 2004, In: Molecular Biology of the Cell. 15, p. 41AResearch output: Contribution to journal › Meeting abstract
Characterization of the SH3 domain of Fyb/SLAP
Krause, M., Sechi, A. S., Hagendorff, P. & Wehland, J., 2000, In: Molecular Biology of the Cell. 11, p. 175A - 176AResearch output: Contribution to journal › Meeting abstract
RIAM, a new Rap1 effector, functions downstream of Rap1 and regulates rapl localization at the plasma membrane and Rap1-induced adhesion
Lafuente, E. M., Carman, C. V., Krause, M., Springer, T. A., Gertler, F. B. & Boussiotis, V. A., 2004, In: Blood. 104, 11, p. 148AResearch output: Contribution to journal › Meeting abstract
Research

Krause Group
We are particularly interested in uncovering signal transduction pathways from growth factor receptors controlling the actin cytoskeleton, which drives plasma membrane protrusion at the leading edge of migrating cells

Cancer Biology
Cancer Biology

King’s MechanoBiology Centre (KMBC)
The King’s MechanoBiology Centre gives a common platform for researchers across different disciplines with complementary interests in mechanobiology
News
Advanced microscopy study reveals molecular details of tight control of cell migration
New research provides novel insights with potentially important implications for our understanding of Nance-Horan Syndrome and cancer metastasis.

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes
Redhead, Y., Gibbins, D., Lana-Elola, E., Watson-Scales, S., Dobson, L., Krause, M., Liu, K. J., Fisher, E. M. C., Green, J. B. A. & Tybulewicz, V. L. J., 26 Apr 2023, In: Development (Cambridge). 150, 8, dev201077.Research output: Contribution to journal › Article › peer-review
GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration
Dobson, L., Barrell, W., Seraj, Z., Lynham, S., Wu, S.-Y., Krause, M. & Liu, K., 26 Sept 2023, In: Cell Reports.Research output: Contribution to journal › Article › peer-review
Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR
Moritz, S., Krause, M., Schlatter, J., Cordes, N. & Vehlow, A., 24 Oct 2021, In: Cancers. 13, 21, 5337.Research output: Contribution to journal › Article › peer-review
Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
Krause, M., Stramer, B., Ameer-Beg, S., Poland, S., Levitt, J., Marcotti, S., Köchl, R., Pallett, T., Law, A.-L., Binti Abd Jalal, S. & Mosis, F., 28 Sept 2021, In: Nature Communications. 12, 1, 1 p., 5687.Research output: Contribution to journal › Article › peer-review
Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation
Brazzo, J. A., Biber, J. C., Nimmer, E., Heo, Y., Ying, L., Zhao, R., Lee, K., Krause, M. & Bae, Y., Jun 2021, In: Journal of Cell Science. 134, 12, jcs257709.Research output: Contribution to journal › Article › peer-review
Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation
Dimchev, G., Amiri, B., Humphries, A. C., Schaks, M., Dimchev, V., Stradal, T. E. B., Faix, J., Krause, M., Way, M., Falcke, M. & Rottner, K., 1 Apr 2020, In: Journal of Cell Science. 133, 7, jcs239020.Research output: Contribution to journal › Article › peer-review
Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration: explants for the study of neural crest cell delamination and migration
Gonzalez Malagon, S. G., Dobson, L., Lopez Munoz, A. M., Dawson, M., Barrell, W., Marangos, P., Krause, M. & Liu, K. J., 3 Oct 2019, In: Journal of Visualized Experiments. 152, e60051.Research output: Contribution to journal › Article › peer-review
FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis
Chan Wah Hak, L., Khan, S., Di Meglio, I., Law, A.-L., Lucken-ardjomande Häsler, S., Quintaneiro, L. M., Ferreira, A. P. A., Krause, M., Mcmahon, H. T. & Boucrot, E., Sept 2018, In: Nature Cell Biology. 20, 9, p. 1023-1031Research output: Contribution to journal › Article › peer-review
Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
Gonzalez Malagon, S. G., Lopez Muñoz, A. M., Doro, D., Bolger, T. G., Poon, E., Tucker, E. R., Adel Al-Lami, H., Krause, M., Phiel, C. J., Chesler, L. & Liu, K. J., 19 Mar 2018, (E-pub ahead of print) In: Nature Communications. 9, 1, 15 p., 1126.Research output: Contribution to journal › Article › peer-review
Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
Bodo, C., Fernandes, C. & Krause, M., 1 Dec 2017, In: Scientific Reports. 7, 1, 5365.Research output: Contribution to journal › Article › peer-review
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
Carmona, G., Perera, U., Gillett, C., Naba, A., Law, A.-L., P Sharma, V., Wang, J., Wyckoff, J., Balsamo, M., Mosis, F., De Piano, M., Monypenny, J., Woodman, N., E McConnell, R., Mouneimne, G., Van Hemelrijck, M., Cao, Y., Condeelis, J., O Hynes, R. & Gertler, F. B. & 1 others, Krause, M., 29 Sept 2016, In: Oncogene. 35, p. 5155–5169Research output: Contribution to journal › Article › peer-review
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Krause, M. & Gautreau, A., 1 Sept 2014, In: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 15, p. 577-590 14 p.Research output: Contribution to journal › Literature review › peer-review
Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo
Law, A.-L., Vehlow, A., Kotini, M., Dodgson, L., Soong, D., Theveneau, E., Bodo, C., Taylor, E., Navarro, C., Perera, U., Michael, M., Dunn, G., Bennett, D., Mayor, R. & Krause, M., Nov 2013, In: Journal of Cell Biology. 203, 4, p. 673-689 23 p., N/A.Research output: Contribution to journal › Article › peer-review
Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis
Vehlow, A., Soong, D., Vizcay-Barrena, G., Bodo, C., Law, A.-L., Perera, U. & Krause, M., 27 Sept 2013, In: The EMBO journal. N/A, N/A, p. 1-13 13 p., N/A.Research output: Contribution to journal › Article › peer-review
ABL AT THE LEADING EDGE
Krause, M., 24 Nov 2011, In: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 12, 1Research output: Contribution to journal › Editorial › peer-review
Morphological Differentiation of Neurons on Microtopographic Substrates Fabricated by Rolled-Up Nanotechnology
Schulze, S., Huang, G., Krause, M., Aubyn, D., Quinones, V. A. B., Schmidt, C. K., Mei, Y. & Schmidt, O. G., Sept 2010, In: ADVANCED ENGINEERING MATERIALS. 12, 9, p. B558 - B564Research output: Contribution to journal › Article › peer-review
c-Abl, Lamellipodin, and Ena/VASP Proteins Cooperate in Dorsal Ruffling of Fibroblasts and Axonal Morphogenesis
Michael, M., Vehlow, A., Navarro, C. & Krause, M., 11 May 2010, In: Current Biology. 20, 9, p. 783 - 791 9 p.Research output: Contribution to journal › Article › peer-review
Drosophila Pico and Its Mammalian Ortholog Lamellipodin Activate Serum Response Factor and Promote Cell Proliferation
Lyulcheva, E., Taylor, E., Michael, M., Vehlow, A., Tan, S., Fletcher, A., Krause, M. & Bennett, D., 11 Nov 2008, In: Developmental Cell. 15, 5, p. 680 - 690 11 p.Research output: Contribution to journal › Article › peer-review
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alpha IIb beta 3
Watanabe, N., Bodin, L., Pandey, M., Krause, M., Coughlin, S., Boussiotis, V. A., Ginsberg, M. H. & Shattil, S. J., Jun 2008, In: Journal of Cell Biology. 181, 7, p. 1211 - 1222 12 p.Research output: Contribution to journal › Article › peer-review
MIG-10/Lamellipodin and the lipid modulator AGE-1/PI3K promote axon guidance and outgrowth in response to Slit and netrin.
Chang, C., Adler, C. E., Krause, M., Clark, S. G., Gertler, F. B., Tessier-Lavigne, M. & Bargmann, C. I., 9 May 2006, In: Current Biology. 16, 9, p. 854 - 862 9 p.Research output: Contribution to journal › Article › peer-review
Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions
Rottner, K., Krause, M., Gimona, M., Small, J. V. & Wehland, J., 2001, In: Molecular Biology of the Cell. 12, 10, p. 3103 - 3113 11 p.Research output: Contribution to journal › Article › peer-review
The Ena/VASP enigma
Krause, M., Bear, J. E., Loureiro, J. J. & Gertler, F. B., 15 Dec 2002, In: Journal of Cell Science. 115, 24, p. 4721 1 p.Research output: Contribution to journal › Article › peer-review
ENA/VASP proteins: Regulators of the actin cytoskeleton and cell migration (review)
Krause, M., Dent, E. W., Bear, J. E., Loureiro, J. J. & Gertler, F. B., 2003, In: Annual Review of Cell and Developmental Biology. 19, p. 541 - 564 24 p.Research output: Contribution to journal › Article › peer-review
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
Krause, M., Leslie, J. D., Stewart, M., Lafuente, E. M., Valderrama, F., Jagannathan, R., Strasser, G. A., Rubinson, D. A., Liu, H., Way, M., Yaffe, M. B., Boussiotis, V. A. & Gertier, F. B., Oct 2004, In: Developmental Cell. 7, 4, p. 571 - 583 13 p.Research output: Contribution to journal › Article › peer-review
Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis
Coppolino, M. G., Krause, M., Hagendorff, P., Monner, D. A., Trimble, W., Grinstein, S., Wehland, J. & Sechi, A. S., 2001, In: Journal of Cell Science. 114, Pt 23, p. 4307 - 4318 12 p.Research output: Contribution to journal › Article › peer-review
Regulating cellular actin assembly
Bear, J. E., Krause, M. & Gertler, F. B., 1 Apr 2001, In: Current Opinion in Cell Biology. 13, 2, p. 158 1 p.Research output: Contribution to journal › Article › peer-review
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility
Bear, J. E., Svitkina, T. M., Krause, M., Schafer, D. A., Loureiro, J. J., Strasser, G. A., Maly, I. V., Chaga, O. Y., Cooper, J. A., Borisy, G. G. & Gertler, F. B., 17 May 2002, In: Cell. 109, 4, p. 509 - 521 13 p.Research output: Contribution to journal › Article › peer-review
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
Krause, M., Sechi, A. S., Konradt, M., Monner, D., Gertler, F. B. & Wehland, J., 3 Apr 2000, In: Journal of Cell Biology. 149, 1, p. 181 1 p.Research output: Contribution to journal › Article › peer-review
RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
Lafuente, E. M., van Puijenbroek, A., Krause, M., Carman, C. V., Freeman, G. J., Berezovskaya, A., Constantine, E., Springer, T. A., Gertier, F. B. & Boussiotis, V. A., Oct 2004, In: Developmental Cell. 7, 4, p. 585 - 595 11 p.Research output: Contribution to journal › Article › peer-review
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1
Lebrand, C., Dent, E. W., Strasser, G. A., Lanier, L. M., Krause, M., Svitkina, T. M., Borisy, G. G. & Gertler, F. B., 8 Apr 2004, In: Neuron. 42, 1, p. 37 - 49 13 p.Research output: Contribution to journal › Article › peer-review
Functional antagonism between Ena/VASP proteins and capping activity in the lamellipodia
Bear, J. E., Svitkina, T. M., Krause, M., Schafer, D., Loureiro, J. J., Strasser, G. A., Cooper, J. A., Borisy, G. & Gertler, F. B., 2001, In: Molecular Biology of the Cell. 12, p. 396A - 396AResearch output: Contribution to journal › Meeting abstract
Lamellipodin, a novel Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
Krause, M., Leslie, J. D., Stewart, M., Lafuente, E. M., Valderrama, F., Jagannathan, R., Strasser, G. A., Rubinson, D. A., Liu, H., Way, M., Yaffe, M. B., Boussiotis, V. A. & Gertler, F. B., 2004, In: Molecular Biology of the Cell. 15, p. 41AResearch output: Contribution to journal › Meeting abstract
Characterization of the SH3 domain of Fyb/SLAP
Krause, M., Sechi, A. S., Hagendorff, P. & Wehland, J., 2000, In: Molecular Biology of the Cell. 11, p. 175A - 176AResearch output: Contribution to journal › Meeting abstract
RIAM, a new Rap1 effector, functions downstream of Rap1 and regulates rapl localization at the plasma membrane and Rap1-induced adhesion
Lafuente, E. M., Carman, C. V., Krause, M., Springer, T. A., Gertler, F. B. & Boussiotis, V. A., 2004, In: Blood. 104, 11, p. 148AResearch output: Contribution to journal › Meeting abstract
Research

Krause Group
We are particularly interested in uncovering signal transduction pathways from growth factor receptors controlling the actin cytoskeleton, which drives plasma membrane protrusion at the leading edge of migrating cells

Cancer Biology
Cancer Biology

King’s MechanoBiology Centre (KMBC)
The King’s MechanoBiology Centre gives a common platform for researchers across different disciplines with complementary interests in mechanobiology
News
Advanced microscopy study reveals molecular details of tight control of cell migration
New research provides novel insights with potentially important implications for our understanding of Nance-Horan Syndrome and cancer metastasis.
