Dr Matthias Krause Academics Supervisors Reader in Cell Biology Research subject areas Biomedical and life sciences Contact details matthias.krause@kcl.ac.uk +44 (0) 20 7848 6959
Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration Lamellipodin-RICTOR Signaling Mediates Glioblastoma Cell Invasion and Radiosensitivity Downstream of EGFR Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration: explants for the study of neural crest cell delamination and migration FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE Steering cell migration: lamellipodium dynamics and the regulation of directional persistence Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis ABL AT THE LEADING EDGE Morphological Differentiation of Neurons on Microtopographic Substrates Fabricated by Rolled-Up Nanotechnology c-Abl, Lamellipodin, and Ena/VASP Proteins Cooperate in Dorsal Ruffling of Fibroblasts and Axonal Morphogenesis Drosophila Pico and Its Mammalian Ortholog Lamellipodin Activate Serum Response Factor and Promote Cell Proliferation Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alpha IIb beta 3 MIG-10/Lamellipodin and the lipid modulator AGE-1/PI3K promote axon guidance and outgrowth in response to Slit and netrin. Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions The Ena/VASP enigma ENA/VASP proteins: Regulators of the actin cytoskeleton and cell migration (review) Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis Regulating cellular actin assembly Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1 Functional antagonism between Ena/VASP proteins and capping activity in the lamellipodia Lamellipodin, a novel Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics Characterization of the SH3 domain of Fyb/SLAP RIAM, a new Rap1 effector, functions downstream of Rap1 and regulates rapl localization at the plasma membrane and Rap1-induced adhesion View all publications
28 September 2021 Advanced microscopy study reveals molecular details of tight control of cell migration New research provides novel insights with potentially important implications for our understanding…