
Professor Rebecca Oakey
Professor of Epigenetics
- Dean for Doctoral Studies
- Training Lead for the KHP Digital Health Hub
- Lead, King's Innovation Scholars Program
Research interests
- Biomedical and life sciences
Biography
Professor Oakey is the Dean for Doctoral Studies in the King's Doctoral College and is part of the Research & Innovation Academic Leadership Team.
D.Phil.: Department of Biochemistry, University of Oxford
Post-doctoral training: Duke University Medical Centre, NC, USA, University of Pennsylvania School of Medicine, PA, USA, Fox Chase Cancer Centre, PA, USA
Faculty positions: Assistant Professor of Pediatrics, Children's Hospital of Philadelphia, PA, USA
Lecturer, Senior Lecturer, Reader & Professor, King's College London.
Rebecca leads the Epigenetics Laboratory in the Department of Medical & Molecular Genetics.
The Oakey laboratory is a multi-disciplinary group at King’s College London working on epigenetic mechanisms, function, and roles during developmental processes. Our work primarily focuses on the epigenetic mark, DNA methylation, a stable mark which regulates gene expression in multiple contexts. We’re investigating this at a mechanistic level by using molecular biology approaches at model loci to decipher the rules of gene regulation. We use computational approaches to leverage ‘omics data to complement our empirical research. Investigation of gene regulation is also applied in clinically relevant contexts ranging from foetal growth defects, neuro-endocrine tumours and endocardial cell development collaborating with colleagues within KCL & GSTT and globally.
Rebecca is passionate about open source training opportunities in digital health for everyone, including early career researchers and the health care work force. Rebecca has championed the development and collation of free self-directed learning resources and is the Lead for the King's Innovation Scholars Program; 'Enabling the big data revolution through skills training - check out our website. She is the Training Lead for the KHP Digital Health Hub - check out our Digital Health Academy website - and supports the learning resources for researchers in digital health for the PharosAI program.
Teaching
Rebecca Oakey is a teacher on the following courses:
- Bioinformatics (Research)
- Genes, Environment & Development in Psychology & Psychiatry
- MBBS1 Genomics
Somatic EPAS1 Variants in Pheochromocytoma and Paraganglioma in Patients With Sickle Cell Disease
White, G., Nonaka, D., Chung, T. T., Oakey, R. J. & Izatt, L., 1 Dec 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 12, p. 3302-3310 9 p.Research output: Contribution to journal › Article › peer-review
SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla
Santambrogio, A., Kemkem, Y., Willis, T. L., Berger, I., Kastriti, M. E., Faure, L., Russell, J. P., Lodge, E. J., Yianni, V., Kövér, B., Oakey, R. J., Altieri, B., Bornstein, S. R., Steenblock, C., Adameyko, I. & Andoniadou, C. L., 2 Jan 2025, In: Nature Communications. 16, 1, 16.Research output: Contribution to journal › Article › peer-review
Using parenclitic networks on phaeochromocytoma and paraganglioma tumours provides novel insights on global DNA methylation
Brempou, D., Montibus, B., Izatt, L., Andoniadou, C. & Oakey, R., 2 Dec 2024, In: Scientific Reports. 14, 1, 29958.Research output: Contribution to journal › Article › peer-review
Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay
Montibus, B., Cain, J., Martinez Nunez, R. & Oakey, R., 18 Oct 2024, In: Genome Research. 34, 12, p. 2163-2175 13 p.Research output: Contribution to journal › Article › peer-review
A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
Chatzikyriakou, P., Brempou, D., Quinn, M., Fishbein, L., Noberini, R., Anastopoulos, I. N., Tufton, N., Lim, E. S., Obholzer, R., Hubbard, J. G., Moonim, M., Bonaldi, T., Nathanson, K. L., Izatt, L. & Oakey, R. J., Dec 2023, In: Clinical Epigenetics. 15, 1, 196.Research output: Contribution to journal › Article › peer-review
Intragenic CpG islands and their impact on gene regulation
Cain, J., Montibus, B. & Oakey, R., 11 Feb 2022, In: Frontiers in Cell and Developmental Biology. 10, 832348.Research output: Contribution to journal › Review article › peer-review
Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms
Castillo, S. C., Montibus, B., Rocha, A., Duke, W., von Meyenn, F., McLornan, D., Harrison, C., Mullally, A., Schulz, R. & Oakey, R. J., Aug 2021, In: Genome Research. 31, 8, p. 1381-1394 14 p.Research output: Contribution to journal › Article › peer-review
Extraction and high-throughput sequencing of oak heartwood DNA: assessing the feasibility of genome-wide DNA methylation profiling
Rossi, F., Crnjar, A., Feliciano, R., Comitani, F., Jahn, L., Malim, G., Southgate, L., Kay, E., Oakey, R., Buggs, R., Moir, A., Kistler, L., Rodriguez Mateos, A. M., Molteni, C. & Schulz, R., 18 Nov 2021, In: PLoS One. 16, 11, e0254971.Research output: Contribution to journal › Article › peer-review
Case report of a man with multiple paragangliomas and pathogenic germline variants in both NF1 and SDHD
Chatzikyriakou, P., Touska, P., Moonim, M. T., Afridi, S., Oakey, R. & Izatt, L., 20 May 2021, In: Cancer Genetics.Research output: Contribution to journal › Article › peer-review
Imprinted gene expression and function of the dopa decarboxylase gene in the developing heart
Prickett, A., Montibus, B., Barkas, N., Amante, S., Franco, M., Cowley, M., Puszyk, W., Shannon, M., Irving, M., Madon-Simon, M., Ward, A., Schulz, R., Baldwin, H. S. & Oakey, R., 19 May 2021, (E-pub ahead of print) In: Frontiers in Cell and Developmental Biology. 00, 00, p. 00 00.Research output: Contribution to journal › Article › peer-review
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
Wilson, B., Boehme, L., Annibali, A., Hodgkinson, A., Carroll, T., Oakey, R. & Seitan, V., 1 Dec 2020, In: Nature Communications. 11, 1, 20 p., 5469.Research output: Contribution to journal › Article › peer-review
Genomic imprinting: An epigenetic regulatory system
Bartolomei, M. S., Oakey, R. J. & Wutz, A., 6 Aug 2020, In: PLoS Genetics. 16, 8, p. e1008970 e1008970.Research output: Contribution to journal › Editorial › peer-review
Is imprinting the result of “friendly fire” by the host defense system?
Ondičová, M., Oakey, R. J. & Walsh, C. P., Apr 2020, In: PLoS Genetics. 16, 4, e1008599.Research output: Contribution to journal › Review article › peer-review
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
Amante, S., Montibus, B., Cowley, M., Barkas, N., Setiadi, J., Saadeh, H., Giemza, J., Contreras Castillo, S., Fleischanderl, K., Schulz, R. & Oakey, R., 4 Sept 2020, In: Nucleic Acids Research. 48, 15, p. 8349-8359 11 p.Research output: Contribution to journal › Article › peer-review
Myocardial Differentiation is Dependent upon Endocardial Signaling During Early Cardiogenesis in vitro
Saint-Jean, L., Barkas, N., Harmelink, C., Tompkins, K. L., Oakey, R. J. & Baldwin, H. S., 8 May 2019, In: Development. 146, 9, dev172619.Research output: Contribution to journal › Article › peer-review
Regulatory links between imprinted genes: Evolutionary predictions and consequences
Patten, M. M., Cowley, M., Oakey, R. J. & Feil, R., 3 Feb 2016, In: Proceedings of the Royal Society B: Biological Sciences. 283, 1824, 20152760.Research output: Contribution to journal › Article › peer-review
Genome-wide methylation analysis in Silver-Russell syndrome patients
Prickett, A. R., Ishida, M., Böhm, S., Frost, J. M., Puszyk, W., Abu-Amero, S., Stanier, P., Schulz, R., Moore, G. E. & Oakey, R. J., Mar 2015, In: Human Genetics. 134, 3, p. 317-32 16 p.Research output: Contribution to journal › Article › peer-review
Network-informed gene ranking tackles genetic heterogeneity in exome-sequencing studies of monogenic disease
Dand, N., Schulz, R., Weale, M. E., Southgate, L., Oakey, R. J., Simpson, M. A. & Schlitt, T., 1 Dec 2015, In: Human Mutation. 36, 12, p. 1135-1144 10 p.Research output: Contribution to journal › Article › peer-review
Imprinted gene expression in hybrids: perturbed mechanisms and evolutionary implications
Wolf, J. B., Oakey, R. J. & Feil, R., Aug 2014, In: Heredity. 113, 2, p. 167-175 9 p.Research output: Contribution to journal › Article › peer-review
Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup
Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., Kendrick, H., Isles, A. R., Parry, A. J., Carney, S., Oakey, R. J., Heisler, L. K., Moorwood, K., Wolf, J. B. & Ward, A., 25 Feb 2014, In: PL o S Biology. 12, 2, 13 p., e1001799.Research output: Contribution to journal › Article › peer-review
Mouse chromosome 7
Williams, R. W., Angel, J. M., Holdener, B. C., Oakey, R. & Hunter, K. W., Oct 1999, In: Mammalian Genome. 10, 10, p. 947Research output: Contribution to journal › Article › peer-review
Encyclopedia of the mouse genome VII. Mouse chromosome 7
Williams, R. W., Holdener, B. C., Angel, J. M., Oakey, R. & Hunter, K. W., 1998, In: Mammalian Genome. 8 Spec No, p. S136-59Research output: Contribution to journal › Article › peer-review
Analysis of transcription initiation in the Panolis flammea nuclear polyhedrosis virus polyhedrin gene
Oakey, R., Cameron, I. R., Davis, B., Davis, E., Possee, R. D. & Oakey, R., Mar 1989, In: Journal of General Virology. 70, 3, p. 769-775 7 p., N/A.Research output: Contribution to journal › Article › peer-review
The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome
Loomes, K. M., Underkoffler, L. A., Morabito, J., Gottlieb, S., Piccoli, D. A., Spinner, N. B., Baldwin, H. S. & Oakey, R. J., Dec 1999, In: Human Molecular Genetics. 8, 13, p. 2443-9 7 p.Research output: Contribution to journal › Article › peer-review
Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development
Shaikh, T. H., Gottlieb, S., Sellinger, B., Chen, F., Roe, B. A., Oakey, R. J., Emanuel, B. S. & Budarf, M. L., Mar 1999, In: Mammalian Genome. 10, 3, p. 322-326 5 p., N/A.Research output: Contribution to journal › Article › peer-review
Goosecoid-like, a gene deleted in DiGeorge and velocardiofacial syndromes, recognizes DNA with a bicoid-like specificity and is expressed in the developing mouse brain
Gottlieb, S., Hanes, S. D., Golden, J. A., Oakey, R. J. & Budarf, M. L., Sept 1998, In: Human Molecular Genetics. 7, 9, p. 1497-505 9 p.Research output: Contribution to journal › Article › peer-review
A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice
Lehman, A. L., Nakatsu, Y., Ching, A., Bronson, R. T., Oakey, R. J., Keiper-Hrynko, N., Finger, J. N., Durham-Pierre, D., Horton, D. B., Newton, J. M., Lyon, M. F. & Brilliant, M. H., 4 Aug 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 16, p. 9436-9441 6 p., N/A.Research output: Contribution to journal › Article › peer-review
Molecular analysis of the cDNAs encoded by the pun and pJ alleles of the pink-eyed dilution locus
Oakey, R., Keiper, N. M., Ching, A. S. & Brilliant, M. H., Apr 1996, In: Mammalian Genome. 7, 4, p. 315-6 2 p.Research output: Contribution to journal › Article › peer-review
Nondisjunction rates and abnormal embryonic development in a mouse cross between heterozygotes carrying a (7, 18) robertsonian translocation chromosome
Oakey, R., Matteson, P. G., Litwin, S., Tilghman, S. M. & Nussbaum, R. L., Oct 1995, In: Genetics. 141, 2, p. 667-74 8 p.Research output: Contribution to journal › Article › peer-review
Mouse chromosome 7
Brilliant, M. H., Williams, R. W., Conti, C. J., Angel, J. M., Oakey, R. J. & Holdener, B. C., 1994, In: Mammalian Genome. 5 Spec No, p. S104-23Research output: Contribution to journal › Article › peer-review
Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes
Tyler-Smith, C., Oakey, R. J., Larin, Z., Fisher, R. B., Crocker, M., Affara, N. A., Ferguson-Smith, M. A., Muenke, M., Zuffardi, O. & Jobling, M. A., Dec 1993, In: Nature Genetics. 5, 4, p. 368-75 8 p.Research output: Contribution to journal › Article › peer-review
Y chromosome DNA haplotyping suggests that most European and Asian men are descended from one of two males
Oakey, R. & Tyler-Smith, C., Jul 1990, In: Genomics. 7, 3, p. 325-30 6 p.Research output: Contribution to journal › Article › peer-review
Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA
Oakey, R., Watson, M. L. & Seldin, M. F., Nov 1992, In: Human Molecular Genetics. 1, 8, p. 613-620 8 p., N/A.Research output: Contribution to journal › Article › peer-review
Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein
Blackshear, P. J., Tuttle, J. S., Oakey, R. J., Seldin, M. F., Chery, M., Philippe, C. & Stumpo, D. J., Sept 1992, In: Genomics. 14, 1, p. 168-174 7 p., N/A.Research output: Contribution to journal › Article › peer-review
A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus
Rochelle, J. M., Watson, M. L., Oakey, R. J. & Seldin, M. F., Sept 1992, In: Genomics. 14, 1, p. 26-31 6 p.Research output: Contribution to journal › Article › peer-review
A linkage map of mouse chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation
Watson, M. L., D'Eustachio, P., Mock, B. A., Steinberg, A. D., Morse, H. C., Oakey, R. J., Howard, T. A., Rochelle, J. M. & Seldin, M. F., 1992, In: Mammalian Genome. 2, 3, p. 158-71 14 p.Research output: Contribution to journal › Article › peer-review
Chromosomal mapping of the high affinity Fc gamma receptor gene
Oakey, R. J., Howard, T. A., Hogarth, P. M., Tani, K. & Seldin, M. F., Mar 1992, In: Immunogenetics. 35, 4, p. 279-282 4 p., N/A.Research output: Contribution to journal › Article › peer-review
The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes
Taylor, G. A., Lai, W. S., Oakey, R. J., Seldin, M. F., Shows, T. B., Eddy, R. L. & Blackshear, P. J., 25 Jun 1991, In: Nucleic Acids Research. 19, 12, p. 3454Research output: Contribution to journal › Article › peer-review
Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution
Oakey, R., Caron, M. G., Lefkowitz, R. J. & Seldin, M. F., Jun 1991, In: Genomics. 10, 2, p. 338-44 7 p.Research output: Contribution to journal › Article › peer-review
A novel role for imprinting in heart development
Prickett, A., Saadeh, H., Schulz, R., Cowley, M., Baldwin, H. S. & Oakey, R. J., Dec 2012, In: Genetical Research. 94, p. 360-360 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
Resetting for the Next Generation
Cowley, M. & Oakey, R. J., 28 Dec 2012, In: MOLECULAR CELL. 48, 6, p. 819-821 3 p., N/A.Research output: Contribution to journal › Editorial › peer-review
Transposable Elements Re-Wire and Fine-Tune the Transcriptome
Cowley, M. & Oakey, R. J., 24 Jan 2013, In: PL o S Genetics. 9, 1, p. N/A 7 p., e1003234.Research output: Contribution to journal › Literature review › peer-review
The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells
Puszyk, W., Down, T., Grimwade, D., Chomienne, C., Oakey, R. J., Solomon, E. & Guidez, F., 3 Jul 2013, In: The EMBO journal. 32, 13, p. 1941-1952 12 p.Research output: Contribution to journal › Article › peer-review
Genomewide and parental allele-specific analysis of CTCF and cohesin DNA binding in mouse brain reveals a tissue-specific binding pattern and an association with imprinted differentially methylated regions
Prickett, A. R., Barkas, N., McCole, R. B., Hughes, S., Amante, S. M., Schulz, R. & Oakey, R. J., Oct 2013, In: Genome Research. 23, 10, p. 1624-1635 12 p.Research output: Contribution to journal › Article › peer-review
A survey of tissue-specific genomic imprinting in mammals
Prickett, A. R. & Oakey, R. J., Aug 2012, In: Molecular Genetics and Genomics: an international journal. 287, 8, p. 621-630 10 p.Research output: Contribution to journal › Article › peer-review
Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus
Cowley, M., Wood, A. J., Böhm, S., Schulz, R. & Oakey, R. J., Oct 2012, In: Nucleic Acids Research. 40, 18, p. 8917-8926 10 p.Research output: Contribution to journal › Article › peer-review
Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes
Proudhon, C., Duffié, R., Ajjan, S., Cowley, M., Iranzo, J., Carbajosa, G., Saadeh, H., Holland, M. L., Oakey, R. J., Rakyan, V. K., Schulz, R. & Bourc'his, D., 28 Sept 2012, In: MOLECULAR CELL. 47, 6, p. 909–920 12 p.Research output: Contribution to journal › Article › peer-review
A CASE-BY-CASE EVOLUTIONARY ANALYSIS OF FOUR IMPRINTED RETROGENES
McCole, R. B., Loughran, N. B., Chahal, M., Fernandes, L. P., Roberts, R. G., Fraternali, F., O'Connell, M. J. & Oakey, R. J., May 2011, In: Evolution. 65, 5, p. 1413 - 1427 15 p.Research output: Contribution to journal › Article › peer-review
The role of imprinted genes in humans
Moore, G. & Oakey, R., 21 Mar 2011, In: GENOME BIOLOGY. 12, 3, 106.Research output: Contribution to journal › Editorial › peer-review
Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes
Monk, D., Arnaud, P., Frost, J. M., Wood, A. J., Cowley, M., Martin-Trujillo, A., Guillaumet-Adkins, A., Platas, I. I., Camprubi, C., Bourc'his, D., Feil, R., Moore, G. E. & Oakey, R. J., Jun 2011, In: Nucleic Acids Research. 39, 11, p. 4577 - 4586 10 p.Research output: Contribution to journal › Article › peer-review
Research

Oakey Epigenetics Group
Oakey Epigenetics Group is led by Professor Rebecca Oakey in the Department of Medical & Molecular Genetics

RNA Biology
RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.
News
Flagship event celebrates women in STEMM ahead of International Women's Day
Flagship event celebrates women in STEMM.

Newly launched King's Health Partners Digital Health Academy
Newly launched King’s Health Partners (KHP) Digital Health Academy.

King's Doctoral College launches
King’s Doctoral College officially launched on Wednesday 2 October at the London Institute for Healthcare Engineering. The Doctoral College empowers our...

King's awarded £15.7m EPSRC funding to revolutionise healthcare delivery
The Engineering & Physical Sciences Research Council (EPSRC) has awarded £15.7m of funding to King’s College London to train the next generation of health...

King's Supervisory Excellence Award Winners 2023
We are delighted to announce the winners of the 2023 King’s Supervisory Excellence Awards and the new Mentoring & Support Awards.

New Digital Health Hub awarded to King's College London as part of Engineering and Physical Sciences Research Council investment
The School of Biomedical Engineering & Imaging Sciences (BMEIS) is part of an investment plan of £16.5 million to create new digital healthcare hubs across...

Launch of the King's Clinical Academic Training Office (KCATO)
The official launch took place on Wednesday 4 May at an evening reception in the studio of the newly re-opened Science Gallery.

Funding boost for data science training in health and bioscience
A training programme to facilitate the understanding of the data landscape in medicine has been funded by UK Research and Innovation (UKRI).

Events

Identifying key genes in the formation of mammalian heart valves
Seminar with Punkita Lohiya
Please note: this event has passed.

The interplay of RNA structure and protein disorder in protein-RNA condensates
Seminar with Professor Jernej Ule
Please note: this event has passed.

The Innovation Scholar Programme: Data Science Training in Health & Bioscience
Seminar with Professor Rebecca Oakey and Emily Robinson
Please note: this event has passed.
Research

Oakey Epigenetics Group
Oakey Epigenetics Group is led by Professor Rebecca Oakey in the Department of Medical & Molecular Genetics

RNA Biology
RNA is at the forefront of biomedical research for its central role in how information is transferred from DNA to protein. This Research Interest Group is open to all interested parties from across the University.
News
Flagship event celebrates women in STEMM ahead of International Women's Day
Flagship event celebrates women in STEMM.

Newly launched King's Health Partners Digital Health Academy
Newly launched King’s Health Partners (KHP) Digital Health Academy.

King's Doctoral College launches
King’s Doctoral College officially launched on Wednesday 2 October at the London Institute for Healthcare Engineering. The Doctoral College empowers our...

King's awarded £15.7m EPSRC funding to revolutionise healthcare delivery
The Engineering & Physical Sciences Research Council (EPSRC) has awarded £15.7m of funding to King’s College London to train the next generation of health...

King's Supervisory Excellence Award Winners 2023
We are delighted to announce the winners of the 2023 King’s Supervisory Excellence Awards and the new Mentoring & Support Awards.

New Digital Health Hub awarded to King's College London as part of Engineering and Physical Sciences Research Council investment
The School of Biomedical Engineering & Imaging Sciences (BMEIS) is part of an investment plan of £16.5 million to create new digital healthcare hubs across...

Launch of the King's Clinical Academic Training Office (KCATO)
The official launch took place on Wednesday 4 May at an evening reception in the studio of the newly re-opened Science Gallery.

Funding boost for data science training in health and bioscience
A training programme to facilitate the understanding of the data landscape in medicine has been funded by UK Research and Innovation (UKRI).

Events

Identifying key genes in the formation of mammalian heart valves
Seminar with Punkita Lohiya
Please note: this event has passed.

The interplay of RNA structure and protein disorder in protein-RNA condensates
Seminar with Professor Jernej Ule
Please note: this event has passed.

The Innovation Scholar Programme: Data Science Training in Health & Bioscience
Seminar with Professor Rebecca Oakey and Emily Robinson
Please note: this event has passed.