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Surface Potential Quantification Engine

SPiQE is the brainchild of a collaboration between neurologists at King’s College London and bioengineers at Imperial College London. It combines the very latest in surface electrode technology with sophisticated spike-detection software. SPiQE functions as an automated analytical pipeline for the detection of spontaneous and voluntary muscle activity. It is non-invasive and well-tolerated by patients. Importantly, this means muscle recordings can be longer than ever before and can be repeated at regular time intervals.

In our Clinical Trials so far, we have focussed on the analysis of fasciculations in motor neuron disease to learn more about this devastating illness.

The project was started in 2015 by Prof Chris Shaw (King’s), Prof Kerry Mills (King’s), Prof Martyn Boutelle (Imperial), Prof Manos Drakakis (Imperial), Dr James Bashford (King’s) and Dr Aidan Wickham (Imperial). Our current team at King’s includes: • Prof Chris Shaw – Professor of Neurology • Dr James Bashford – NIHR Clinical Lecturer in Neurology • Dr Mark Crook-Rumsey – Post-doctoral researcher • Miss Anna Carobin – MRC PhD candidate • Miss Judith Bilgorai – PhD candidate The project has received significant contributions from Clinical Neuroscience Masters students, including Urooba Masood (2018), Cristina Cabassi (2019), Domen Planinc (2019), Kevin Chan (2020), Abdi Musa (2020), Dina Ekanayake (2021) and Nazifa Muhamood (2021), as well as junior doctors Dr Tom Weddell (2019), Dr Kate Wannop (2020) and Dr Arina Tamborska (2020). We have collaborated with several groups, including Dr Emma Hodson-Tole (Manchester Metropolitan University), Professor Ping Zhou (University of Texas) and Dr Mark Baker (Newcastle University).


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Our funders and sponsors

The Neuroscience division at King's houses the clinical expertise for the SPiQE study program. We also work with these sponsors: