King's College London - Professor Gareth E Jones

Jones Group

Professor Gareth E Jones

Professor of Cell Biology
Head, Cell Motility & Cytoskeleton Section

Email: gareth.jones@kcl.ac.uk
Tel: +44 (0) 20 7848 6466
Fax: +44 (0) 20 7848 6435

Biography

Ph.D. Cell Biology, University of Glasgow 1972
B.Sc.(Hons) Zoology, University College London 1968

Past Appointments

Lecturer in Cell & Developmental Biology, Queen Elizabeth College London, 1972-1985
Royal Society/Leverhulme Trust Visiting Research Fellow 1985
Lecturer, then Reader in Cell Biology, King’s College London, 1986-1996

Research Interests

My research is directed towards understanding the molecular mechanisms regulating directed cell movements and adhesion turnover. Much of the laboratory effort is coordinated with that of some of my colleagues in the Cell Motility & Cytoskeleton Section; Graham Dunn, Anne Ridley and Maddy Parsons.

Recent reviews

Franz, C.M., Jones, G.E. & Ridley, A.J. (2002).
Cell Migration in Development and Disease. Dev.Cell 2: 153-158.
Bailly, M. & Jones, G.E. (2003)
Polarised migration: cofilin holds the front. Curr.Biol.13: R128-R130.
Calle, Y., Chou, H-C., Thrasher, A.J. & Jones, G.E. (2004). Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells. J.Pathol. 204: 460-469.
Calle, Y., Burns, S., Thrasher, A.J. & Jones, G.E. (2006).
The leukocyte podosome. Eur.J.Cell Biol. 85: 151-157.
Anton, I.M. & Jones, G.E. (2006).
WIP: a multifunctional protein involved in actin cytoskeleton regulation. Eur.J.Cell Biol. 85: 295-304.
Insall, R & Jones, G.E. (2006).
Moving matters: signals and mechanisms in directed cell migration. Nature Cell Biol. 8: 776-779.
Anton, I.M., Jones, G.E, Wandosell, F., Geha, R. & Ramesh, N. (2007).
WASP-interacting protein (WIP): working in polymerisation and much more. Trends in Cell Biol. 17: 555-562.
Calle, Y., Anton, I.M., Thrasher, A.J. & Jones, G.E. (2008).
WASP and WIP regulate podosomes in migrating leukocytes.
J.Microsc. 231: 494-505.

Research Papers

De Noronha, S., Hardy, S., Sinclair, J., Blundell, M.P., Strid, J., Schulz, O., Zwirner, J., Jones, G.E., Katz, D.R., Kinnon, C. & Thrasher, A.J. (2005). Impaired dendritic cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein.
Blood 105: 1590-1597.
Welch, H.C.E., Condliffe, A.M., Milne, L., Ferguson, G.J., Hill, K., Webb, L.M.C., Okkenhaug, K., Coadwell, W.J., Andrews, S.R., Thelen, M., Jones, G.E., Hawkins, P.T. & Stephens, L.R. (2005). P-Rex1 regulates neutrophil function.
Curr.Biol. 15: 1867-1873.
Wells, C.M.,* Ahmed, T., Masters, J.W.R. & Jones, G.E.* (2005). Rho family GTPases are activated during HGF-stimulated prostate cancer cell scattering.
Cell Motil. Cytoskel. 62: 180-194.
Chadborn, N.H., Ahmed, A.I., Holt, M.R., Prinjha, R., Dunn, G.A., Jones, G.E. & Eickholt, B.J. (2006). PTEN couples Sema3A signalling to growth cone collapse.
J. Cell Sci. 119: 951-957.
Calle, Y., Chou, H-C., Thrasher A.J. & Jones, G.E. (2006). Inhibition of calpain stabilises podosomes and results in impaired dendritic cell motility.
J.Cell Sci. 119: 2375-2385.
Ancliff, P.J., Blundell, M.P., Cory, G., Calle, Y., Worth, A., Kempeski, H., Burns, S., Jones, G.E., Sinclair, J., Kinnon, C., Hann, I.M., Gale, R.E., Linch, D.C., & Thrasher, A.J. (2006). Two novel activating mutations in the Wiskott-Aldrich Syndrome protein resulting in congenital neutropenia.
Blood 108: 2182-2189.
Fletcher, G., Jones, G.E.*, Patient, R. & Snape, A*. (2006). A role for GATA factors in Xenopus gastrulation movements.
Mech. Dev.123: 730-745.
Chou, H-C, Anton, I.M., Holt, M., Curcio, C., Lanzardo, S., Worth, A., Burns, S., Thrasher, A.J., Jones, G.E.* & Calle, Y*. (2006). WIP regulates the stability and localisation of WASP to podosomes in migrating dendritic cells.
Curr.Biol. 16: 2337-2344.
Ferguson, J.G., Milne, L., Kulkarni, S., Sasaki, T., Walker, S., Andrews, S., Crabbe, T., Finan, P., Jones, G.E., Jackson, S., Camps, M., Rommel, C., Wymann, M., Hirsch, E., Hawkins, P. & Stephens, L. (2007). PI3Kγ has an important context-dependent role in neutrophil chemokinesis.
Nature Cell Biol. 9: 86-91.
Moulding, D.A., Blundell, M.P., Spiller, D.G., White, M.R.H, Cory,G.O., Calle, Y., Kempski, H., Sinclair, J., Ancliff, P. J., Kinnon, C., Jones, G.E. & Thrasher, A.J. (2007). Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.
J.Exp.Med. 204: 2213-2224.
Serrels, B., Serrels, A., Brunton, V.G., Holt, M., McLean, G.W., Gray, C.H., Jones, G.E.* & Frame, M.C.* (2007). Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.
Nature Cell Biol. 9: 1046-1056.
Ahmed, T., Shea, K., Masters, J.R.W., Jones, G.E.* & Wells, C.M.* (2008). A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF.
Cell. Signal. 20: 1320-1328.
Blundell, M.P., Bouma, G., Calle, Y., Jones, G.E., Kinnon, C. & Thrasher, A.J. (2008). Improvement of migratory defects in a murine model of Wiskott-Aldrich Syndrome gene therapy. Molec.Ther.16: 836-844.
Holt, M., Calle, Y., Sutton, D., Critchley, D. Jones, G.E. & Dunn, G.A. (2008). Quantifying cell-matrix adhesion dynamics in living cells using interference reflection microscopy.
J. Microsc. 232: 73-81.

King's College London - Homepage