Professor Giovanna Lombardi Academics Supervisors Professor of Human Transplant Immunology Research subject areas Immunology
Clinical grade expansion protocol for the manufacture of Thymus-derived Treg cells for clinical application Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance Mesenchymal stromal cells as rescue therapy in biologic-refractory psoriasis: insights from a case series Nanoneedle-Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T-Cells Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent The Immunomodulatory Role of Regulatory T Cells in Preterm Birth and Associated Pregnancy Outcomes The Potential of Autologous Regulatory T Cell (Treg) Therapy to Prevent Cardiac Allograft Vasculopathy in Paediatric Heart Transplant Recipients The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review A GMP Protocol for the Manufacture of Tregs for Clinical Application Can regulatory T cells improve outcomes of sensitised patients after HLA-Ab incompatible renal transplantation: study protocol for the Phase IIa GAMECHANgER-1 trial Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease Highly sensitised individuals present a distinct Tregs signature compared to unsensitised individuals on hemodialysis Human skin CD141+ dendritic cells regulate cutaneous immunity via the neuropeptide urocortin 2 Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival Regulatory T cells in the peripheral blood of women with gestational diabetes: a systematic review and meta-analysis Regulatory T cells in the peripheral blood of women with gestational diabetes: a systematic review and meta-analysis Soluble Collectin 11 (CL-11) Acts as an Immunosuppressive Molecule Potentially Used by Stem Cell-Derived Retinal Epithelial Cells to Modulate T Cell Response Autocrine vitamin D signaling switches off pro-inflammatory programs of T Isolation and freezing of human peripheral blood mononuclear cells from pregnant patients Pluripotent stem cell-derived hepatocytes inhibit T cell proliferation in vitro through tryptophan starvation Regulatory T cell niche in the bone marrow, a new player in Haematopoietic stem cell transplantation Transplantation Without Overimmunosuppression (TWO) study protocol: A phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance? Augmented Expansion of Treg Cells From Healthy and Autoimmune Subjects via Adult Progenitor Cell Co-Culture B lymphocytes contribute to indirect pathway T cell sensitization via acquisition of extracellular vesicles Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive Immunological considerations and challenges for regenerative cellular therapies In utero therapy for the treatment of Sickle Cell Disease: taking advantage of the fetal immune system Isolation and expansion of thymus-derived regulatory T cells for use in paediatric heart transplant patients Isolation and expansion of thymus-derived regulatory T cells for use in pediatric heart transplant patients Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency: Nox2-deficient Tregs improve heart allograft outcome PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype Potential application of T-follicular regulatory cell therapy in transplantation Purification and Immunophenotypic Characterization of Human CD24hiCD38hi and CD24hiCD27+ Regulatory B Cells in Transplantation Regulatory T Cells in Pregnancy Adverse Outcomes: A Systematic Review and Meta-Analysis Regulatory T Cells in Pregnancy adverse Outcomes (Rutepo): A Systematic Review & Meta-Analysis Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment Beyond Bacterial Killing: NADPH oxidase 2 is an immunomodulator Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology The Theoretical Basis of In Utero Hematopoietic Stem Cell Transplantation and its use in the treatment of Blood disorders Treg sensitivity to FasL and relative IL-2 deprivation drive Idiopathic Aplastic Anemia immune dysfunction: Mechanism of Treg depletion in AA Applicability, Safety And Biological Activity Of Regulatory T Cell Therapy In Liver Transplantation Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances Correction of Defective T-regulatory Cells From Patients With Crohn’s Disease by Ex Vivo Ligation of Retinoic Acid Receptor Alpha Getting to the Heart of the Matter: The role of Regulatory T-cells (Tregs) in Cardiovascular Disease (CVD) and Atherosclerosis View all publications