The function of a biological system is determined by the composition, interaction, and organisation of its constituent cells. Gathering molecular information about complex cellular systems with spatial context will elucidate a plethora of biological processes, including development and disease progression.
The Spatial Biology Network is a cross-faculty research interest group that brings together researchers from various disciplines, ranging from technology development and molecular biology, to bioinformatics and clinical translational research, to explore the complexity of spatial biology.
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Publications
Tumor microenvironments with an active type-I interferon response are sensitive to inhibitors of heme degradation
Sosnowska, D., Cheung, T. S., Sarkar, J., Opzoomer, J. W., Feehan, K. T., Anstee, J. E., Woodman, C. A., Keddar, M. R., Clayton, K., Ali, S., MacMorland, W., Yang, D. D., Rosekilly, J., Gillett, C. E., Ciccarelli, F. D., Buus, R., Spicer, J., Grigoriadis, A. & Arnold, J. N., 1 Jul 2025, (Accepted/In press) In: JCI Insight.Research output: Contribution to journal › Article › peer-review
TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer
Beatson, R. E., Parente-Pereira, A. C., Halim, L., Cozzetto, D., Hull, C., Whilding, L. M., Martinez, O., Taylor, C. A., Obajdin, J., Luu Hoang, K. N., Draper, B., Iqbal, A., Hardiman, T., Zabinski, T., Man, F., de Rosales, R. T. M., Xie, J., Aswad, F., Achkova, D. & Joseph, C. Y. R. & 11 others, Ciprut, S., Adami, A., Roider, H. G., Hess-Stumpp, H., Győrffy, B., Quist, J., Grigoriadis, A., Sommer, A., Tutt, A. N. J., Davies, D. M. & Maher, J., 21 Dec 2021, In: Cell Reports Medicine. 2, 12, 100473.Research output: Contribution to journal › Article › peer-review
Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis
Chander, A., Iacovacci, J., Pellon, A., Kataria, R., Grigoriadis, A., Maher, J., Sears, C., Bachrach, G., Urbano, T. G., Lei, M., Petkar, I., Kong, A., Ng, T., Orlandi, E., Iacovelli, N. A., De Cecco, L., Serafini, M. S., Moyes, D., Rancati, T. & Ferreira, M. R., Aug 2024, In: Cancer Communications. 44, 8, p. 879-883 5 p.Research output: Contribution to journal › Letter › peer-review
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
International Immuno-Oncology Biomarker Working Group, Dec 2022, In: npj Breast Cancer. 6, 1, 16.Research output: Contribution to journal › Review article › peer-review
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects
Verghese, G., Lennerz, J. K., Ruta, D., Ng, W., Thavaraj, S., Siziopikou, K. P., Naidoo, T., Rane, S., Salgado, R., Pinder, S. E. & Grigoriadis, A., Aug 2023, In: Journal of pathology. 260, 5, p. 551-563 13 p.Research output: Contribution to journal › Review article › peer-review
Leveraging circulating microbial DNA for early cancer detection
Kataria, R., Shoaie, S., Grigoriadis, A. & Wan, J. C. M., Nov 2023, In: Trends in Cancer. 9, 11, p. 879-882 4 p.Research output: Contribution to journal › Short survey › peer-review
PAK6 acts downstream of IQGAP3 to promote contractility in triple negative breast cancer cells
Wells, C., Pipili, K., Grigoriadis, A., Babteen, N., Kuwair, L., Bulu, M., Quist, J., Ong, K., Tutt, A. & Pitaluga, R., Sept 2024, In: Cellular Signalling. 121, 111233.Research output: Contribution to journal › Article › peer-review
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
Wall, I., Boulat, V., Shah, A., Blenman, K. R. M., Wu, Y., Alberts, E., Calado, D. P., Salgado, R. & Grigoriadis, A., 17 Sept 2022, In: Cancers. 14, 18Research output: Contribution to journal › Review article › peer-review
Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers
Lau, H. S. H., Tan, V. K. M., Tan, B. K. T., Sim, Y., Quist, J., Thike, A. A., Tan, P. H., Pervaiz, S., Grigoriadis, A. & Sabapathy, K., 20 Oct 2023, In: npj Breast Cancer. 9, 1, 14 p., 84.Research output: Contribution to journal › Article › peer-review
Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)
Tovey, H., Sipos, O., Parker, J. S., Hoadley, K. A., Quist, J., Kernaghan, S., Kilburn, L., Salgado, R., Loi, S., Kennedy, R. D., Roxanis, I., Gazinska, P., Pinder, S. E., Bliss, J., Perou, C. M., Haider, S., Grigoriadis, A., Tutt, A. & Cheang, M. C. U., 15 Sept 2023, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 29, 18, p. 3691-3705 15 p.Research output: Contribution to journal › Article › peer-review
B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma
Crescioli, S., Correa, I., Ng, J., Willsmore, Z. N., Laddach, R., Chenoweth, A., Chauhan, J., Di Meo, A., Stewart, A., Kalliolia, E., Alberts, E., Adams, R., Harris, R. J., Mele, S., Pellizzari, G., Black, A. B. M., Bax, H. J., Cheung, A., Nakamura, M. & Hoffmann, R. M. & 23 others, Terranova-Barberio, M., Ali, N., Batruch, I., Soosaipillai, A., Prassas, I., Ulndreaj, A., Chatanaka, M. K., Nuamah, R., Kannambath, S., Dhami, P., Geh, J. L. C., MacKenzie Ross, A. D., Healy, C., Grigoriadis, A., Kipling, D., Karagiannis, P., Dunn-Walters, D. K., Diamandis, E. P., Tsoka, S., Spicer, J., Lacy, K. E., Fraternali, F. & Karagiannis, S. N., 8 Jun 2023, In: Nature Communications. 14, 1, 3378.Research output: Contribution to journal › Article › peer-review
Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large-scale studies.
Verghese, G., Li, M., Liu, F., Lohan, A., Kurian, N. C., Meena, S., Gazinska, P., Shah, A., Oozeer, A., Chan, T., Opdam, M., Linn, S., Gillett, C., Alberts, E., Hardiman, T., Jones, S. V., Thavaraj, S., Jones, L., Salgado, R. & Pinder, S. E. & 3 others, Rane, S. U., Sethi, A. & Grigoriadis, A., Aug 2023, In: Journal of pathology. 260, 4, p. 376-389 14 p.Research output: Contribution to journal › Article › peer-review
B Cells in Breast Cancer Pathology
Li, M., Quintana, A., Alberts, E., Hung, M. S., Boulat, V., Ripoll, M. M. & Grigoriadis, A., 28 Feb 2023, In: Cancers. 15, 5, 1517.Research output: Contribution to journal › Review article › peer-review
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
Wall, I., Boulat, V., Shah, A., Blenman, K., Wu, Y., Calado, D., Salgado, R. & Grigoriadis, A., 17 Sept 2022, (E-pub ahead of print) In: Cancers. 14Research output: Contribution to journal › Review article › peer-review
CDK Inhibition Primes for Anti-PD-L1 Treatment in Triple-Negative Breast Cancer Models
Cheung, A., Chenoweth, A. M., Quist, J., Sow, H. S., Malaktou, C., Ferro, R., Hoffmann, R. M., Osborn, G., Sachouli, E., French, E., Marlow, R., Lacy, K. E., Papa, S., Grigoriadis, A. & Karagiannis, S. N., 11 Jul 2022, In: Cancers. 14, 14, 21 p., 3361.Research output: Contribution to journal › Article › peer-review
Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC
Harrasser, M., Gohil, S. H., Lau, H., Della Peruta, M., Muczynski, V., Patel, D., Miranda, E., Grigoriadis, K., Grigoriadis, A., Granger, D., Evans, R. & Nathwani, A. C., Dec 2022, In: Breast Cancer Research. 24, 1, 39.Research output: Contribution to journal › Article › peer-review
Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance
Tarantino, D., Walker, C., Weekes, D., Pemberton, H., Davidson, K., Torga, G., Frankum, J., Mendes-Pereira, A. M., Prince, C., Ferro, R., Brough, R., Pettitt, S. J., Lord, C. J., Grigoriadis, A. & Tutt, A. N., 5 Aug 2022, In: Oncogene. 41, 32, p. 3969-3977 9 p.Research output: Contribution to journal › Article › peer-review
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer
Grand Challenge PRECISION Consortium, Jun 2022, In: Nature genetics. 54, 6, p. 850-860 11 p.Research output: Contribution to journal › Article › peer-review
TGF-β1 potentiates Vγ9Vδ2 T-cell adoptive immunotherapy of cancer
Beatson, R., Parente Pereira, A., Halim, L., Cozzetto, D., Hull, C., Whilding, L., Martinez, O., Taylor, C., Obajdin, J., Luu Hoang, K. N., Draper, B., Iqbal, A., Hardiman, T., Zabinski, T., Man, F., T. M. de Rosales, R., Xie, J., Aswad, F., Achkova, D. & Ricardo Joseph, C.-Y. & 11 others, Ciprut, S., Adami, A., Roider, H., Hess-Stump, H., Gyorffy, B., Quist, J., Grigoriadis, A., Sommer, A., Tutt, A., Maher, J. & Davies, D., 18 Nov 2021, (Accepted/In press) In: Cell Reports Medicine.Research output: Contribution to journal › Article › peer-review
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors
Muliaditan, T., Halim, L., Whilding, L., Draper, B., Achkova, D., Kausar, F., Glover, M., Bechman, N., Arulappu, A., Sanchez, J., Flaherty, K. R., Obajdin, J., Grigoriadis, K., Antoine, P., Larcombe-Young, D., Hull, C., Buus, R., Gordon, P., Grigoriadis, A. & Davies, D. & 2 others, Schurich, A. & Maher, J., 21 Dec 2021, In: Cell Reports Medicine. 2, 12, 100457.Research output: Contribution to journal › Article › peer-review
Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells
Alberts, E., Wall, I., Calado, D. P. & Grigoriadis, A., 28 May 2021, In: Frontiers in Molecular Biosciences. 8, 673051.Research output: Contribution to journal › Review article › peer-review
Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes In Triple-Negative Breast Cancer
Harris, R. J., Cheung, A., Ng, J. C. F., Laddach, R., Chenoweth, A. M., Crescioli, S., Fittall, M., Dominguez-Rodriguez, D., Roberts, J., Levi, D., Liu, F., Alberts, E., Quist, J., Santaolalla, A., Pinder, S. E., Gillett, C., Hammar, N., Irshad, S., van Hemelrijck, M. & Dunn-Walters, D. K. & 7 others, Fraternali, F., Spicer, J. F., Lacy, K. E., Tsoka, S., Grigoriadis, A., Tutt, A. N. J. & Karagiannis, S. N., 15 Aug 2021, In: Cancer Research. 81, 16, p. 4290-4304 15 p.Research output: Contribution to journal › Article › peer-review
Systemic immune reaction in axillary lymph nodes adds to tumor infiltrating lymphocytes in triple-negative breast cancer prognostication
Liu, F., Hardiman, T., Wu, K., Quist, J., Gazinska, P., Ng, T., Purushotham, A., Salgado, R., Guo, X., Pinder, S. & Grigoriadis, A., 5 Jul 2021, (E-pub ahead of print) In: npj Breast Cancer.Research output: Contribution to journal › Article › peer-review
Random forest modelling of high-dimensional mixed-type data for breast cancer classification
Quist, J., Taylor, L., Staaf, J. & Grigoriadis, A., 1 Mar 2021, In: Cancers. 13, 5, p. 1-15 15 p., 991.Research output: Contribution to journal › Article › peer-review
Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in triple negative breast cancer: the TNT trial
Sipos, O., Tovey, H., Quist, J., Hyder, S., Nowinski, S., Gazinska, P., Kernaghan, S., Toms, C., Maguire, S., Orr, N., Linn, S., Owen, J., Gillett, C., Pinder, S., Bliss, J., Tutt, A., Cheang, M. C. U. & Grigoriadis, A., 1 Jan 2021, In: Annals of Oncology. 32, 1, p. 58-65 8 p.Research output: Contribution to journal › Article › peer-review
Upregulation of IL15RA in Triple Negative Breast Cancer (TNBC) Promotes Tumour Cell Growth and Motility and Can Activate an Immune Cell Response
Marra, P., Mathew, S., Grigoriadis, A., Wu, Y., Kyle-Cezar, F., Watkins, J., Hessey, S., Gazinska, P., Hayday, A. & Tutt, A., May 2013, In: Annals of Oncology. 24, p. iii38Research output: Contribution to journal › Article › peer-review
Profiles of genome complexity identify HORMAD1 as a driver of homologous recombination deficiency and platinum therapy response in triple-negative breast cancer
Grigoriadis, A., Weekes, D., Watkins, J. A., Gazinska, P., Frankum, J., Lord, C., Ashworth, A., Ford, J. M., Telli, M. & Tutt, A., May 2015, In: Annals of Oncology. 26, p. iii15Research output: Contribution to journal › Article › peer-review
The PIM1 Kinase Shows Genome Driven Upregulation, Suppresses Apoptosis, Enables Colony Formation and Cell Migration and is a Potential Target in Triple-Negative Breast Cancer
Maristany, F. B., Grigoriadis, A., Noël, E., Gazinska, P., de Rinaldis, E., Pinder, S., Marra, P. & Tutt, A., May 2013, In: Annals of Oncology. 24, p. iii22Research output: Contribution to journal › Article › peer-review
Clinical patterns of metastatic spread from formalin-fixed, paraffin-embedded (FFPE) expression profiles: A case-control study of 1,357 breast cancer patients
Lawler, K., Papouli, E., Tutt, A., Ng, T., Pinder, S., Parker, P., Holmberg, L., Gillett, C., Grigoriadis, A. & Purushotham, A., May 2015, In: Annals of Oncology. 26, p. iii10Research output: Contribution to journal › Article › peer-review
Big Data: The challenge for small research groups in the era of cancer genomics
Noor, A. M., Holmberg, L., Gillett, C. & Grigoriadis, A., 17 Nov 2015, In: British Journal of Cancer. 113, 10, p. 1405-1412 8 p.Research output: Contribution to journal › Article › peer-review
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases
De Piano, M., Manuelli, V., Zadra, G., Otte, J., Edqvist, P.-H., Ponten, F., Nowinski, S., Niaouris, A., Grigoriadis, A., Loda, M., Van Hemelrijck, M. & Wells, C. M., 30 Apr 2020, In: Oncogene. 39, 18, p. 3666–3679 14 p.Research output: Contribution to journal › Article › peer-review
Invasive breast cancer over four decades reveals persisting poor metastatic outcomes in treatment resistant subgroup – the “ATRESS” phenomenon
Jurrius, P., Green, T., Garmo, H., Young, M., Cariati, M., Gillett, C., Mera, A., Harries, M., Grigoriadis, A., Pinder, S., Holmberg, L. & Purushotham, A., 1 Apr 2020, In: Breast. 50, p. 39-48 10 p.Research output: Contribution to journal › Article › peer-review
Immune-stroma-histological (ISH)-risk score identifies low-risk group within LN-positive breast cancers
Grigoriadis, A., Gazinska, P., Pinder, S., Pai, T., Irshad, S., Wu, Y., Gillett, C. E., Tutt, A. N. & Coolen, A. C. C., 1 Oct 2017, In: Annals of oncology : official journal of the European Society for Medical Oncology. 28, p. vii27-vii28Research output: Contribution to journal › Meeting Abstract › peer-review
An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer
Wu, Y., Kyle-Cezar, F., Woolf, R. T., Naceur-Lombardelli, C., Owen, J., Biswas, D., Lorenc, A., Vantourout, P., Gazinska, P., Grigoriadis, A., Tutt, A. & Hayday, A., 9 Oct 2019, In: Science Translational Medicine. 11, 513, eaax9364.Research output: Contribution to journal › Article › peer-review
Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis
Santa Olalla, A., Van Hemelrijck, M., Holmberg, L. H., Grigoriadis, A., Ghuman, S., Hammar, N., Lambe, M., Garmo, H. G., Walldius, G. & Jungner, I., 23 Jul 2019, In: BMC Molecular Biology. 20, 1, 30 p., 28.Research output: Contribution to journal › Article › peer-review
Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.
Tornilli, G., Knowlson, C., Kenrick, H., Cooke, J., Mirza, H., Aurrekoetxea-Rodriguez, I., Vivanco, M., Buckley, N., Grigoriadis, A. & Smalley, M. J., 26 Dec 2018, In: Cell Reports. p. 3674 3692 p., 10.1016/j.celrep.2018.11.103.Research output: Contribution to journal › Article › peer-review
Integrin-mediated macrophage adhesion promotes lymphovascular dissemination in breast cancer
Evans, R., Flores-Borja, F., Nassiri, S., Miranda, E., Lawler, K., Grigoriadis, A., Monypenny, J., Gillett, C., Owen, J., Gordon, P., Male, V., Cheung, A., Noor, F., Barber, P., Marlow, R., Francesch-Domenech, E., Fruhwirth, G., Squadrito, M., Vojnovic, B. & Tutt, A. & 3 others, Festy, F., De Palma, M. & Ng, T., 14 May 2019, In: Cell Reports. 27, 7, p. 1967-1978.e4Research output: Contribution to journal › Article › peer-review
Repurposing tin mesoporphyrin as a novel immune checkpoint therapy in the treatment of cancer: A preclinical evaluation.
Arnold, J. N., Muliaditan, T., Opzoomer, J. W., Caron, J., Okesola, M., Kosti, P., Lall, S., Van Hemelrijck, M., Dazzi, F., Tutt, A., Grigoriadis, A., Gillett, C., Madden, S. F., Burchell, J. M., Kordasti, S., Diebold, S. S. & Spicer, J. F., 20 May 2018, In: Journal of Clinical Oncology. 36, 15Research output: Contribution to journal › Meeting Abstract › peer-review
Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases
Ng, J. C. F., Quist, J., Grigoriadis, A., Malim, M. H. & Fraternali, F., 20 Feb 2019, In: Nucleic Acids Research. 47, 3, p. 1178-1194 17 p.Research output: Contribution to journal › Article › peer-review
A four-gene decision tree signature classification of triple-negative breast cancer: Implications for targeted therapeutics: Integrative analysis of triple-negative breast cancers
Quist, J., Mirza, H., Cheang, M. C. U., Telli, M. L., O'Shaughnessy, J., Lord, C. J., Tutt, A. N. J. & Grigoriadis, A., 10 Oct 2018, (E-pub ahead of print) In: MOLECULAR CANCER THERAPEUTICS.Research output: Contribution to journal › Article › peer-review
Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients
Chatterjee, G., Pai, T., Avery-Kiejda, K., Scott, R., Spencer, J. M., Pinder, S. E. & Grigoriadis, A., 24 Oct 2018, (Accepted/In press) In: Breast Cancer Research. 20, 1, p. 143Research output: Contribution to journal › Article › peer-review
Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer
Cheung, A., Opzoomer, J. W., Ilieva, K. M., Gazinska, P., Hoffmann, R. M., Mirza, H., Marlow, R., Francesch-Domenech, E., Fittall, M. W., Dominguez Rodriguez, D., Clifford, A., Badder, L., Patel, N., Mele, S., Pellizzari, G., Bax, H. J., Crescioli, S., Petranyi, G., Larcombe-Young, D. & Josephs, D. H. & 9 others, Canevari, S., Figini, M., Pinder, S. E., Nestle, F. O., Gillett, C., Spicer, J., Grigoriadis, A., Tutt, A. & Karagiannis, S. N., 15 Oct 2018, In: Clinical Cancer Research. 24, 20, p. 5098-5111Research output: Contribution to journal › Article › peer-review
An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration
Tajadura-Ortega, V., Garg, R., Allen, R., Owczarek, C., Bright, M. D., Kean, S., Mohd-Noor, A., Grigoriadis, A., Elston, T. C., Hahn, K. M. & Ridley, A. J., 6 Mar 2018, In: BMC Biology. 16, 1, 29.Research output: Contribution to journal › Article › peer-review
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer
Braso Maristany, F., Filosto, S., Catchpole, S., Marlow, R., Quist, J., Francesch-Domenech, E., Plumb, D. A., Zakka, L., Gazinska, P., Liccardi, G., Meier, P., Gris-Oliver, A., Cheang, M. C. U., Perdrix Rosell, A., Shafat, M., Noel, E., Patel, N., McEachern, K., Scaltriti, M. & Castel, P. & 7 others, Noor, F., Buus, R., Mathew, S., Serra, V., Marra, P., Grigoriadis, A. & Tutt, A., 1 Nov 2016, In: Nature Medicine. 22, 11, p. 1303-1313Research output: Contribution to journal › Article › peer-review
PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression
Shah, V., Nowinski, S., Levi, D., Shinomiya, I., Kebaier Ep Chaabouni, N., Gillett, C., Grigoriadis, A., Graham, T. A., Roylance, R., Simpson, M. A., Pinder, S. E. & Sawyer, E. J., 17 Jan 2017, In: Breast Cancer Research. 19, 1, p. 7Research output: Contribution to journal › Article › peer-review
Repurposing tin mesoporphyrin as an immune checkpoint inhibitor shows therapeutic efficacy in preclinical models of cancer
Muliaditan, T., Opzoomer, J. W., Caron, J., Okesola, M., Kosti, P., Lall, S., Van Hemelrijck, M., Dazzi, F., Tutt, A., Grigoriadis, A., Gillett, C. E., Madden, S. F., Burchell, J. M., Kordasti, S., Diebold, S. S., Spicer, J. F. & Arnold, J. N., 1 Apr 2018, In: Clinical Cancer Research. 24, 7, p. 1617-1628 12 p.Research output: Contribution to journal › Article › peer-review
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial
Tutt, A., Tovey, H., Cheang, M. C. U., Kernaghan, S., Kilburn, L., Gazinska, P., Owen, J., Abraham, J., Barrett, S., Barrett-Lee, P., Brown, R., Chan, S., Dowsett, M., Flanagan, J. M., Fox, L., Grigoriadis, A., Gutin, A., Harper-Wynne, C., Hatton, M. Q. & Hoadley, K. A. & 19 others, Parikh, J., Parker, P., Perou, C. M., Roylance, R., Shah, V., Shaw, A., Smith, I. E., Timms, K. M., Wardley, A. M., Wilson, G., Gillett, C., Lanchbury, J. S., Ashworth, A., Rahman, N., Harries, M., Ellis, P., Pinder, S. E., Bliss, J. M. & TNT Trialists, 1 May 2018, In: Nature Medicine. 24, 5, p. 628–637Research output: Contribution to journal › Article › peer-review
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
Patel, N., Weekes, D., Drosopoulos, K., Gazinska, P., Noel, E., Rashid, M., Mirza, H., Quist, J., Brasó-Maristany, F., Mathew, S., Ferro, R., Pereira, A. M., Prince, C., Noor, F., Francesch-Domenech, E., Marlow, R., de Rinaldis, E., Grigoriadis, A., Linardopoulos, S. & Marra, P. & 1 others, Tutt, A. N. J., 13 Mar 2018, In: Nature Communications. 9, 1, 16 p., 1044.Research output: Contribution to journal › Article › peer-review
Evaluation of CDK12 protein expression as a potential novel biomarker for DNA damage response-targeted therapies in breast cancer
Naidoo, K., Wai, P. T., Maguire, S. L., Daley, F., Haider, S., Kriplani, D., Campbell, J., Mirza, H., Grigoriadis, A., Tutt, A., Moseley, P. M., Abdel-Fatah, T. M. A., Chan, S. Y. T., Madhusudan, S., Rhaka, E. A., Ellis, I. O., Lord, C. J., Yuan, Y., Green, A. R. & Natrajan, R., 1 Jan 2018, In: Molecular Cancer Therapeutics. 17, 1, p. 306-315 10 p.Research output: Contribution to journal › Article › peer-review
Systematic identification of functionally relevant risk alleles to stratify aggressive versus indolent prostate cancer
Nowinski, S. E., Santa Olalla, A., O’Leary, B., Loda, M., Mirchandani, A., Emberton, M., Van Hemelrijck, M. & Grigoriadis, A., 5 Feb 2018, In: Oncotarget. 9, p. 12812-12824Research output: Contribution to journal › Article › peer-review
Activities

Microsoft Teams Chat
For colleagues within King's there is a Microsoft Chat for this group. Please apply here to join the chat. (Internal Link)

Upcoming Spatial Biology Network Meetings
14th September 2023 12th October 2023 16th November 2023 Dates for 2024, to be determined
Publications
Tumor microenvironments with an active type-I interferon response are sensitive to inhibitors of heme degradation
Sosnowska, D., Cheung, T. S., Sarkar, J., Opzoomer, J. W., Feehan, K. T., Anstee, J. E., Woodman, C. A., Keddar, M. R., Clayton, K., Ali, S., MacMorland, W., Yang, D. D., Rosekilly, J., Gillett, C. E., Ciccarelli, F. D., Buus, R., Spicer, J., Grigoriadis, A. & Arnold, J. N., 1 Jul 2025, (Accepted/In press) In: JCI Insight.Research output: Contribution to journal › Article › peer-review
TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer
Beatson, R. E., Parente-Pereira, A. C., Halim, L., Cozzetto, D., Hull, C., Whilding, L. M., Martinez, O., Taylor, C. A., Obajdin, J., Luu Hoang, K. N., Draper, B., Iqbal, A., Hardiman, T., Zabinski, T., Man, F., de Rosales, R. T. M., Xie, J., Aswad, F., Achkova, D. & Joseph, C. Y. R. & 11 others, Ciprut, S., Adami, A., Roider, H. G., Hess-Stumpp, H., Győrffy, B., Quist, J., Grigoriadis, A., Sommer, A., Tutt, A. N. J., Davies, D. M. & Maher, J., 21 Dec 2021, In: Cell Reports Medicine. 2, 12, 100473.Research output: Contribution to journal › Article › peer-review
Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis
Chander, A., Iacovacci, J., Pellon, A., Kataria, R., Grigoriadis, A., Maher, J., Sears, C., Bachrach, G., Urbano, T. G., Lei, M., Petkar, I., Kong, A., Ng, T., Orlandi, E., Iacovelli, N. A., De Cecco, L., Serafini, M. S., Moyes, D., Rancati, T. & Ferreira, M. R., Aug 2024, In: Cancer Communications. 44, 8, p. 879-883 5 p.Research output: Contribution to journal › Letter › peer-review
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
International Immuno-Oncology Biomarker Working Group, Dec 2022, In: npj Breast Cancer. 6, 1, 16.Research output: Contribution to journal › Review article › peer-review
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects
Verghese, G., Lennerz, J. K., Ruta, D., Ng, W., Thavaraj, S., Siziopikou, K. P., Naidoo, T., Rane, S., Salgado, R., Pinder, S. E. & Grigoriadis, A., Aug 2023, In: Journal of pathology. 260, 5, p. 551-563 13 p.Research output: Contribution to journal › Review article › peer-review
Leveraging circulating microbial DNA for early cancer detection
Kataria, R., Shoaie, S., Grigoriadis, A. & Wan, J. C. M., Nov 2023, In: Trends in Cancer. 9, 11, p. 879-882 4 p.Research output: Contribution to journal › Short survey › peer-review
PAK6 acts downstream of IQGAP3 to promote contractility in triple negative breast cancer cells
Wells, C., Pipili, K., Grigoriadis, A., Babteen, N., Kuwair, L., Bulu, M., Quist, J., Ong, K., Tutt, A. & Pitaluga, R., Sept 2024, In: Cellular Signalling. 121, 111233.Research output: Contribution to journal › Article › peer-review
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
Wall, I., Boulat, V., Shah, A., Blenman, K. R. M., Wu, Y., Alberts, E., Calado, D. P., Salgado, R. & Grigoriadis, A., 17 Sept 2022, In: Cancers. 14, 18Research output: Contribution to journal › Review article › peer-review
Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers
Lau, H. S. H., Tan, V. K. M., Tan, B. K. T., Sim, Y., Quist, J., Thike, A. A., Tan, P. H., Pervaiz, S., Grigoriadis, A. & Sabapathy, K., 20 Oct 2023, In: npj Breast Cancer. 9, 1, 14 p., 84.Research output: Contribution to journal › Article › peer-review
Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)
Tovey, H., Sipos, O., Parker, J. S., Hoadley, K. A., Quist, J., Kernaghan, S., Kilburn, L., Salgado, R., Loi, S., Kennedy, R. D., Roxanis, I., Gazinska, P., Pinder, S. E., Bliss, J., Perou, C. M., Haider, S., Grigoriadis, A., Tutt, A. & Cheang, M. C. U., 15 Sept 2023, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 29, 18, p. 3691-3705 15 p.Research output: Contribution to journal › Article › peer-review
B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma
Crescioli, S., Correa, I., Ng, J., Willsmore, Z. N., Laddach, R., Chenoweth, A., Chauhan, J., Di Meo, A., Stewart, A., Kalliolia, E., Alberts, E., Adams, R., Harris, R. J., Mele, S., Pellizzari, G., Black, A. B. M., Bax, H. J., Cheung, A., Nakamura, M. & Hoffmann, R. M. & 23 others, Terranova-Barberio, M., Ali, N., Batruch, I., Soosaipillai, A., Prassas, I., Ulndreaj, A., Chatanaka, M. K., Nuamah, R., Kannambath, S., Dhami, P., Geh, J. L. C., MacKenzie Ross, A. D., Healy, C., Grigoriadis, A., Kipling, D., Karagiannis, P., Dunn-Walters, D. K., Diamandis, E. P., Tsoka, S., Spicer, J., Lacy, K. E., Fraternali, F. & Karagiannis, S. N., 8 Jun 2023, In: Nature Communications. 14, 1, 3378.Research output: Contribution to journal › Article › peer-review
Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large-scale studies.
Verghese, G., Li, M., Liu, F., Lohan, A., Kurian, N. C., Meena, S., Gazinska, P., Shah, A., Oozeer, A., Chan, T., Opdam, M., Linn, S., Gillett, C., Alberts, E., Hardiman, T., Jones, S. V., Thavaraj, S., Jones, L., Salgado, R. & Pinder, S. E. & 3 others, Rane, S. U., Sethi, A. & Grigoriadis, A., Aug 2023, In: Journal of pathology. 260, 4, p. 376-389 14 p.Research output: Contribution to journal › Article › peer-review
B Cells in Breast Cancer Pathology
Li, M., Quintana, A., Alberts, E., Hung, M. S., Boulat, V., Ripoll, M. M. & Grigoriadis, A., 28 Feb 2023, In: Cancers. 15, 5, 1517.Research output: Contribution to journal › Review article › peer-review
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
Wall, I., Boulat, V., Shah, A., Blenman, K., Wu, Y., Calado, D., Salgado, R. & Grigoriadis, A., 17 Sept 2022, (E-pub ahead of print) In: Cancers. 14Research output: Contribution to journal › Review article › peer-review
CDK Inhibition Primes for Anti-PD-L1 Treatment in Triple-Negative Breast Cancer Models
Cheung, A., Chenoweth, A. M., Quist, J., Sow, H. S., Malaktou, C., Ferro, R., Hoffmann, R. M., Osborn, G., Sachouli, E., French, E., Marlow, R., Lacy, K. E., Papa, S., Grigoriadis, A. & Karagiannis, S. N., 11 Jul 2022, In: Cancers. 14, 14, 21 p., 3361.Research output: Contribution to journal › Article › peer-review
Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC
Harrasser, M., Gohil, S. H., Lau, H., Della Peruta, M., Muczynski, V., Patel, D., Miranda, E., Grigoriadis, K., Grigoriadis, A., Granger, D., Evans, R. & Nathwani, A. C., Dec 2022, In: Breast Cancer Research. 24, 1, 39.Research output: Contribution to journal › Article › peer-review
Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance
Tarantino, D., Walker, C., Weekes, D., Pemberton, H., Davidson, K., Torga, G., Frankum, J., Mendes-Pereira, A. M., Prince, C., Ferro, R., Brough, R., Pettitt, S. J., Lord, C. J., Grigoriadis, A. & Tutt, A. N., 5 Aug 2022, In: Oncogene. 41, 32, p. 3969-3977 9 p.Research output: Contribution to journal › Article › peer-review
Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer
Grand Challenge PRECISION Consortium, Jun 2022, In: Nature genetics. 54, 6, p. 850-860 11 p.Research output: Contribution to journal › Article › peer-review
TGF-β1 potentiates Vγ9Vδ2 T-cell adoptive immunotherapy of cancer
Beatson, R., Parente Pereira, A., Halim, L., Cozzetto, D., Hull, C., Whilding, L., Martinez, O., Taylor, C., Obajdin, J., Luu Hoang, K. N., Draper, B., Iqbal, A., Hardiman, T., Zabinski, T., Man, F., T. M. de Rosales, R., Xie, J., Aswad, F., Achkova, D. & Ricardo Joseph, C.-Y. & 11 others, Ciprut, S., Adami, A., Roider, H., Hess-Stump, H., Gyorffy, B., Quist, J., Grigoriadis, A., Sommer, A., Tutt, A., Maher, J. & Davies, D., 18 Nov 2021, (Accepted/In press) In: Cell Reports Medicine.Research output: Contribution to journal › Article › peer-review
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors
Muliaditan, T., Halim, L., Whilding, L., Draper, B., Achkova, D., Kausar, F., Glover, M., Bechman, N., Arulappu, A., Sanchez, J., Flaherty, K. R., Obajdin, J., Grigoriadis, K., Antoine, P., Larcombe-Young, D., Hull, C., Buus, R., Gordon, P., Grigoriadis, A. & Davies, D. & 2 others, Schurich, A. & Maher, J., 21 Dec 2021, In: Cell Reports Medicine. 2, 12, 100457.Research output: Contribution to journal › Article › peer-review
Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells
Alberts, E., Wall, I., Calado, D. P. & Grigoriadis, A., 28 May 2021, In: Frontiers in Molecular Biosciences. 8, 673051.Research output: Contribution to journal › Review article › peer-review
Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes In Triple-Negative Breast Cancer
Harris, R. J., Cheung, A., Ng, J. C. F., Laddach, R., Chenoweth, A. M., Crescioli, S., Fittall, M., Dominguez-Rodriguez, D., Roberts, J., Levi, D., Liu, F., Alberts, E., Quist, J., Santaolalla, A., Pinder, S. E., Gillett, C., Hammar, N., Irshad, S., van Hemelrijck, M. & Dunn-Walters, D. K. & 7 others, Fraternali, F., Spicer, J. F., Lacy, K. E., Tsoka, S., Grigoriadis, A., Tutt, A. N. J. & Karagiannis, S. N., 15 Aug 2021, In: Cancer Research. 81, 16, p. 4290-4304 15 p.Research output: Contribution to journal › Article › peer-review
Systemic immune reaction in axillary lymph nodes adds to tumor infiltrating lymphocytes in triple-negative breast cancer prognostication
Liu, F., Hardiman, T., Wu, K., Quist, J., Gazinska, P., Ng, T., Purushotham, A., Salgado, R., Guo, X., Pinder, S. & Grigoriadis, A., 5 Jul 2021, (E-pub ahead of print) In: npj Breast Cancer.Research output: Contribution to journal › Article › peer-review
Random forest modelling of high-dimensional mixed-type data for breast cancer classification
Quist, J., Taylor, L., Staaf, J. & Grigoriadis, A., 1 Mar 2021, In: Cancers. 13, 5, p. 1-15 15 p., 991.Research output: Contribution to journal › Article › peer-review
Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in triple negative breast cancer: the TNT trial
Sipos, O., Tovey, H., Quist, J., Hyder, S., Nowinski, S., Gazinska, P., Kernaghan, S., Toms, C., Maguire, S., Orr, N., Linn, S., Owen, J., Gillett, C., Pinder, S., Bliss, J., Tutt, A., Cheang, M. C. U. & Grigoriadis, A., 1 Jan 2021, In: Annals of Oncology. 32, 1, p. 58-65 8 p.Research output: Contribution to journal › Article › peer-review
Upregulation of IL15RA in Triple Negative Breast Cancer (TNBC) Promotes Tumour Cell Growth and Motility and Can Activate an Immune Cell Response
Marra, P., Mathew, S., Grigoriadis, A., Wu, Y., Kyle-Cezar, F., Watkins, J., Hessey, S., Gazinska, P., Hayday, A. & Tutt, A., May 2013, In: Annals of Oncology. 24, p. iii38Research output: Contribution to journal › Article › peer-review
Profiles of genome complexity identify HORMAD1 as a driver of homologous recombination deficiency and platinum therapy response in triple-negative breast cancer
Grigoriadis, A., Weekes, D., Watkins, J. A., Gazinska, P., Frankum, J., Lord, C., Ashworth, A., Ford, J. M., Telli, M. & Tutt, A., May 2015, In: Annals of Oncology. 26, p. iii15Research output: Contribution to journal › Article › peer-review
The PIM1 Kinase Shows Genome Driven Upregulation, Suppresses Apoptosis, Enables Colony Formation and Cell Migration and is a Potential Target in Triple-Negative Breast Cancer
Maristany, F. B., Grigoriadis, A., Noël, E., Gazinska, P., de Rinaldis, E., Pinder, S., Marra, P. & Tutt, A., May 2013, In: Annals of Oncology. 24, p. iii22Research output: Contribution to journal › Article › peer-review
Clinical patterns of metastatic spread from formalin-fixed, paraffin-embedded (FFPE) expression profiles: A case-control study of 1,357 breast cancer patients
Lawler, K., Papouli, E., Tutt, A., Ng, T., Pinder, S., Parker, P., Holmberg, L., Gillett, C., Grigoriadis, A. & Purushotham, A., May 2015, In: Annals of Oncology. 26, p. iii10Research output: Contribution to journal › Article › peer-review
Big Data: The challenge for small research groups in the era of cancer genomics
Noor, A. M., Holmberg, L., Gillett, C. & Grigoriadis, A., 17 Nov 2015, In: British Journal of Cancer. 113, 10, p. 1405-1412 8 p.Research output: Contribution to journal › Article › peer-review
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases
De Piano, M., Manuelli, V., Zadra, G., Otte, J., Edqvist, P.-H., Ponten, F., Nowinski, S., Niaouris, A., Grigoriadis, A., Loda, M., Van Hemelrijck, M. & Wells, C. M., 30 Apr 2020, In: Oncogene. 39, 18, p. 3666–3679 14 p.Research output: Contribution to journal › Article › peer-review
Invasive breast cancer over four decades reveals persisting poor metastatic outcomes in treatment resistant subgroup – the “ATRESS” phenomenon
Jurrius, P., Green, T., Garmo, H., Young, M., Cariati, M., Gillett, C., Mera, A., Harries, M., Grigoriadis, A., Pinder, S., Holmberg, L. & Purushotham, A., 1 Apr 2020, In: Breast. 50, p. 39-48 10 p.Research output: Contribution to journal › Article › peer-review
Immune-stroma-histological (ISH)-risk score identifies low-risk group within LN-positive breast cancers
Grigoriadis, A., Gazinska, P., Pinder, S., Pai, T., Irshad, S., Wu, Y., Gillett, C. E., Tutt, A. N. & Coolen, A. C. C., 1 Oct 2017, In: Annals of oncology : official journal of the European Society for Medical Oncology. 28, p. vii27-vii28Research output: Contribution to journal › Meeting Abstract › peer-review
An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer
Wu, Y., Kyle-Cezar, F., Woolf, R. T., Naceur-Lombardelli, C., Owen, J., Biswas, D., Lorenc, A., Vantourout, P., Gazinska, P., Grigoriadis, A., Tutt, A. & Hayday, A., 9 Oct 2019, In: Science Translational Medicine. 11, 513, eaax9364.Research output: Contribution to journal › Article › peer-review
Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis
Santa Olalla, A., Van Hemelrijck, M., Holmberg, L. H., Grigoriadis, A., Ghuman, S., Hammar, N., Lambe, M., Garmo, H. G., Walldius, G. & Jungner, I., 23 Jul 2019, In: BMC Molecular Biology. 20, 1, 30 p., 28.Research output: Contribution to journal › Article › peer-review
Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.
Tornilli, G., Knowlson, C., Kenrick, H., Cooke, J., Mirza, H., Aurrekoetxea-Rodriguez, I., Vivanco, M., Buckley, N., Grigoriadis, A. & Smalley, M. J., 26 Dec 2018, In: Cell Reports. p. 3674 3692 p., 10.1016/j.celrep.2018.11.103.Research output: Contribution to journal › Article › peer-review
Integrin-mediated macrophage adhesion promotes lymphovascular dissemination in breast cancer
Evans, R., Flores-Borja, F., Nassiri, S., Miranda, E., Lawler, K., Grigoriadis, A., Monypenny, J., Gillett, C., Owen, J., Gordon, P., Male, V., Cheung, A., Noor, F., Barber, P., Marlow, R., Francesch-Domenech, E., Fruhwirth, G., Squadrito, M., Vojnovic, B. & Tutt, A. & 3 others, Festy, F., De Palma, M. & Ng, T., 14 May 2019, In: Cell Reports. 27, 7, p. 1967-1978.e4Research output: Contribution to journal › Article › peer-review
Repurposing tin mesoporphyrin as a novel immune checkpoint therapy in the treatment of cancer: A preclinical evaluation.
Arnold, J. N., Muliaditan, T., Opzoomer, J. W., Caron, J., Okesola, M., Kosti, P., Lall, S., Van Hemelrijck, M., Dazzi, F., Tutt, A., Grigoriadis, A., Gillett, C., Madden, S. F., Burchell, J. M., Kordasti, S., Diebold, S. S. & Spicer, J. F., 20 May 2018, In: Journal of Clinical Oncology. 36, 15Research output: Contribution to journal › Meeting Abstract › peer-review
Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases
Ng, J. C. F., Quist, J., Grigoriadis, A., Malim, M. H. & Fraternali, F., 20 Feb 2019, In: Nucleic Acids Research. 47, 3, p. 1178-1194 17 p.Research output: Contribution to journal › Article › peer-review
A four-gene decision tree signature classification of triple-negative breast cancer: Implications for targeted therapeutics: Integrative analysis of triple-negative breast cancers
Quist, J., Mirza, H., Cheang, M. C. U., Telli, M. L., O'Shaughnessy, J., Lord, C. J., Tutt, A. N. J. & Grigoriadis, A., 10 Oct 2018, (E-pub ahead of print) In: MOLECULAR CANCER THERAPEUTICS.Research output: Contribution to journal › Article › peer-review
Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients
Chatterjee, G., Pai, T., Avery-Kiejda, K., Scott, R., Spencer, J. M., Pinder, S. E. & Grigoriadis, A., 24 Oct 2018, (Accepted/In press) In: Breast Cancer Research. 20, 1, p. 143Research output: Contribution to journal › Article › peer-review
Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer
Cheung, A., Opzoomer, J. W., Ilieva, K. M., Gazinska, P., Hoffmann, R. M., Mirza, H., Marlow, R., Francesch-Domenech, E., Fittall, M. W., Dominguez Rodriguez, D., Clifford, A., Badder, L., Patel, N., Mele, S., Pellizzari, G., Bax, H. J., Crescioli, S., Petranyi, G., Larcombe-Young, D. & Josephs, D. H. & 9 others, Canevari, S., Figini, M., Pinder, S. E., Nestle, F. O., Gillett, C., Spicer, J., Grigoriadis, A., Tutt, A. & Karagiannis, S. N., 15 Oct 2018, In: Clinical Cancer Research. 24, 20, p. 5098-5111Research output: Contribution to journal › Article › peer-review
An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration
Tajadura-Ortega, V., Garg, R., Allen, R., Owczarek, C., Bright, M. D., Kean, S., Mohd-Noor, A., Grigoriadis, A., Elston, T. C., Hahn, K. M. & Ridley, A. J., 6 Mar 2018, In: BMC Biology. 16, 1, 29.Research output: Contribution to journal › Article › peer-review
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer
Braso Maristany, F., Filosto, S., Catchpole, S., Marlow, R., Quist, J., Francesch-Domenech, E., Plumb, D. A., Zakka, L., Gazinska, P., Liccardi, G., Meier, P., Gris-Oliver, A., Cheang, M. C. U., Perdrix Rosell, A., Shafat, M., Noel, E., Patel, N., McEachern, K., Scaltriti, M. & Castel, P. & 7 others, Noor, F., Buus, R., Mathew, S., Serra, V., Marra, P., Grigoriadis, A. & Tutt, A., 1 Nov 2016, In: Nature Medicine. 22, 11, p. 1303-1313Research output: Contribution to journal › Article › peer-review
PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression
Shah, V., Nowinski, S., Levi, D., Shinomiya, I., Kebaier Ep Chaabouni, N., Gillett, C., Grigoriadis, A., Graham, T. A., Roylance, R., Simpson, M. A., Pinder, S. E. & Sawyer, E. J., 17 Jan 2017, In: Breast Cancer Research. 19, 1, p. 7Research output: Contribution to journal › Article › peer-review
Repurposing tin mesoporphyrin as an immune checkpoint inhibitor shows therapeutic efficacy in preclinical models of cancer
Muliaditan, T., Opzoomer, J. W., Caron, J., Okesola, M., Kosti, P., Lall, S., Van Hemelrijck, M., Dazzi, F., Tutt, A., Grigoriadis, A., Gillett, C. E., Madden, S. F., Burchell, J. M., Kordasti, S., Diebold, S. S., Spicer, J. F. & Arnold, J. N., 1 Apr 2018, In: Clinical Cancer Research. 24, 7, p. 1617-1628 12 p.Research output: Contribution to journal › Article › peer-review
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial
Tutt, A., Tovey, H., Cheang, M. C. U., Kernaghan, S., Kilburn, L., Gazinska, P., Owen, J., Abraham, J., Barrett, S., Barrett-Lee, P., Brown, R., Chan, S., Dowsett, M., Flanagan, J. M., Fox, L., Grigoriadis, A., Gutin, A., Harper-Wynne, C., Hatton, M. Q. & Hoadley, K. A. & 19 others, Parikh, J., Parker, P., Perou, C. M., Roylance, R., Shah, V., Shaw, A., Smith, I. E., Timms, K. M., Wardley, A. M., Wilson, G., Gillett, C., Lanchbury, J. S., Ashworth, A., Rahman, N., Harries, M., Ellis, P., Pinder, S. E., Bliss, J. M. & TNT Trialists, 1 May 2018, In: Nature Medicine. 24, 5, p. 628–637Research output: Contribution to journal › Article › peer-review
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
Patel, N., Weekes, D., Drosopoulos, K., Gazinska, P., Noel, E., Rashid, M., Mirza, H., Quist, J., Brasó-Maristany, F., Mathew, S., Ferro, R., Pereira, A. M., Prince, C., Noor, F., Francesch-Domenech, E., Marlow, R., de Rinaldis, E., Grigoriadis, A., Linardopoulos, S. & Marra, P. & 1 others, Tutt, A. N. J., 13 Mar 2018, In: Nature Communications. 9, 1, 16 p., 1044.Research output: Contribution to journal › Article › peer-review
Evaluation of CDK12 protein expression as a potential novel biomarker for DNA damage response-targeted therapies in breast cancer
Naidoo, K., Wai, P. T., Maguire, S. L., Daley, F., Haider, S., Kriplani, D., Campbell, J., Mirza, H., Grigoriadis, A., Tutt, A., Moseley, P. M., Abdel-Fatah, T. M. A., Chan, S. Y. T., Madhusudan, S., Rhaka, E. A., Ellis, I. O., Lord, C. J., Yuan, Y., Green, A. R. & Natrajan, R., 1 Jan 2018, In: Molecular Cancer Therapeutics. 17, 1, p. 306-315 10 p.Research output: Contribution to journal › Article › peer-review
Systematic identification of functionally relevant risk alleles to stratify aggressive versus indolent prostate cancer
Nowinski, S. E., Santa Olalla, A., O’Leary, B., Loda, M., Mirchandani, A., Emberton, M., Van Hemelrijck, M. & Grigoriadis, A., 5 Feb 2018, In: Oncotarget. 9, p. 12812-12824Research output: Contribution to journal › Article › peer-review
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