Strucural Biology
Section Head: Professor Brian Sutton
The Structural Biology Section focuses on determining protein structures by X-ray crystallography and NMR, supported by other biophysical techniques and computer-aided molecular modelling. Current research interests include: antibody-receptor interactions in allergy; antibiotic resistance enzyme structure and mechanism; protein-RNA and protein-DNA interactions; anti-viral drug design; muscle protein structure; proteins involved in neurodegenerative disease; structural bioinformatics and molecular dynamics simulation.
The Section is equipped for X-ray structure determination, including a robotic crystallisation facility, an X-ray scanner to test crystals in situ during crystallisation, and three X-ray data collection systems. NMR facilities include 400, 500 and 700 MHz spectrometers in the King’s Centre for Biomolecular Spectroscopy. Research is funded by the MRC, BBSRC, EPSRC, The Wellcome Trust, The European Union Framework Programme, medical charities and industrial collaborations.
Section Members
1 Joint appointment with the Division of Asthma, Allergy and Lung Biology
2 Member of the Cardiovascular Division
³ Joint appointment with the Department of Physics