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Dr Luigi Gnudi MD PhD FRCP FASN

Professor of Diabetes and Metabolic Medicine
Honorary Consultant in Diabetes and Endocrinology
Head, Unit for Metabolic Medicine, Cardiovascular Division 

Gnudi,Luigi

Research Laboratories

3rd Floor, Franklin-Wilkins Building 
King's College London - Waterloo Campus, Stamford Street, London SE1 9NH
Phone:   +44(0) 20 78484465 (PA, Ms Monica Nelson-Iye)

Clinical Research Unit

Department of Diabetes and Endocrinology
3rd Floor Southwark Wing, Guy’s Hospital, London SE1 9RT
Phone:    +44 (0) 20 718 81932/81931
Fax:         +44 (0) 20 74078786

Biography

Luigi Gnudi obtained his MD with Honours from the University of Parma (Italy) in 1988. He subsequently joined the residency programme at the School of Diabetes and Endocrinology at the University of Padua-Italy (1989-1993). During 1993-1995, he worked as a postdoctoral fellow with Prof Barbara B Kahn at Beth Israel Hospital, Harvard Medical School in Boston. In 1998 he obtained a PhD in Endocrinological Sciences from the University of Milan. He became a Fellow of both the Royal College of Physicians and the American Society of Nephrology in 2005. Dr Gnudi joined the Unit for Metabolic Medicine (within the Department of Diabetes, Endocrinology and Internal Medicine) in 1997 as Senior Lecturer and was promoted to Professor of Diabetes and Metabolic Medicine in 2011. He became Head of the Unit for Metabolic Medicine in 2010. Prof Gnudi is an Honorary Consultant Physician in Diabetes, Endocrinology and Metabolic Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust.

Prof Gnudi is subject editor for Nephrology dialysis and Transplantation, Metabolism, Journal of Endocrinological Investigation, and Diabetologia. Prof Gnudi is a member of Diabetes UK, European Association for the Study of Diabetes, American Diabetes Association, American Society of Nephrology, European Diabetic Nephropathy Study Group, Physiological Society, ERA-EDTA, and also Faculty 1000. 

 

Research group

  • Diabetes and Metabolic Medicine      

Research interests

Historically, the Unit for Metabolic Medicine’s research has been concerned with microvascular complications in diabetes with a special interest in the kidney. The Unit has been instrumental in discovering early markers of renal disease in diabetes (most importantly microalbuminuria, Prof Viberti), looking at their prognostic value and examining treatment options for prevention of renal failure. The results of this research have been translated into everyday clinical practice and have expanded from diabetes to essential hypertension, ischaemic heart disease, and heart failure.

Under Prof Gnudi, this clinical translational work continues in the Unit. As a Member of the NIHR Biomedical Research Centre’s Faculty of Translational Medicine, Prof Gnudi is actively involved as lead PI in conjunction with the Joint Clinical Trials Office in a number of clinical trials looking new treatment for the metabolic control of diabetes and chronic vascular complication.

Prof Gnudi’s current experimental work is mainly concerned with the study of the mechanisms regulating vascular permeability and vascular integrity in the kidney with the object of preventing end stage renal failure. The current research programme of the Unit covers the discovery of new targetable pathways for the treatment of chronic cardio-renal vascular complications in patients with diabetes.

The research focuses mainly on mechanisms of glomerular injury initiated by metabolic, haemodynamic, immunological, and oxidative insults. Loss of glomerular vascular permselectivity, marked by leakage of protein into the urinary space, is a key first step in many clinical conditions which induce vessel wall injury. Proteinuria is a recognised marker of renal disease and represents generalised vascular damage. Our programme utilises in vitro (cell culture), ex vivo (kidney biopsies, peripheral circulating progenitor endothelial cells), and in vivo (animal model of proteinuria, transgenics) research approaches, and provides an ideal setting for integrated research. The Unit is funded by government agencies (BBSRC, MRC), charities (Diabetes UK, NKRF, EFSD), and industry.

Current research areas are:                      

  • The role of vascular growth factors in glomerular capillary permeability (Experimental, translational research).
  • Role of oxidative stress, mitochondria, and endoplasmic reticulum, in diabetic cardiovascular complication (Experimental, translational research).
  • Study of marker/novel treatment for cardio-renal vascular disease in patients with diabetes (Clinical research).

  • Group members

    Professors

    • Professor G Viberti (Emeritus Professor - Clinical)

    Senior Lecturers

    • Dr J Karalliedde   (Clinical Senior Lecturer, Consultant in Diabetes and Endocrinology) 

    Clinical Lecturers

    • Dr G Maltese (Clinical Lecturer)

    Postdoctoral Fellows

    • Dr Nilolaos Fountoulakis
    • Dr Maria Flaquer Rife

    Research Assistants

    • Miss A Hayward

    Current PhD Students

    • Miss Jiaqi Pan
    • Ms Saima Ajaz

    Research Nurses

    • Ms Negar Tadayon

    Clinical Research Administrator

    • Ms Rhanya Chaabane
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