Professor Michael Marber BSc MBBS PhD FRCP
Professor of Cardiology, Honorary Consultant Cardiologist
King's College London
Guy’s & St Thomas’ Hospitals
The Rayne Institute, St Thomas' Hospital
Lambeth Palace Rd, London SE1 7EH
Professor Michael Marber graduated from the Middlesex Hospital Medical School in 1984 having intercalated a BSc Hons in Biophysics. After clinical training at the Brompton, St Peter’s and St George’s Hospitals he was awarded a British Heart Foundation Intermediate Fellowship to undertake his PhD in Physiology with Derek Yellon and David Latchman at University College London. This Fellowship was extended to allow postdoctoral training with Dr Wolfgang Dillmann at University of California, San Diego. In 1996 he was appointed as a Senior Lecturer, Honorary Consultant Cardiologist at United Medical and Dental Schools of Guy's and St Thomas ' Hospitals and subsequently promoted to Professor of Cardiology at King's College London in 1999.
Professor Marber has served as Chairman of the British Society for Cardiovascular Research, member of the Council of the British Cardiovascular Society, member of the Physiological Sciences Panel of the Welcome Trust, member of the Project Grant Committee of the British Heart Foundation, as a consultant and external reviewer for Health Technology Appraisals by the National Institute for Clinical Excellence and the Genetic Therapy Advisory Committee of the Department of Health, as Dean of the St Thomas’ Hospital Campus and as a member of the Cardiovascular Panel of the 2008 Research Assessment Exercise. He currently co-leads the Cardiovascular Theme within the National Institute of Health Research (NIHR) Comprehensive Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust (GSTFT) and King's College London (KCL), is a member of the Chair and Programme Grants Committee of the British Heart Foundation, is Chairman of the Academic and Research Committee of the British Cardiovascular Society and serves on the Editorial Boards of the Journal of the American College of Cardiology, European Heart Journal, Dialogues in Cardiology, Heart and Metabolism, Basic Research in Cardiology and Current Vascular Pharmacology.
Professor Marber contributes to the undergraduate medical curriculum and received the student vote as “Best Clinical Teacher” for 2007.
The research group’s interests focus on the processes that contribute to myocardial injury during ischaemia and reperfusion. In particular we are interested in the processes underlying adaptation to ischaemia, predominantly ischaemic preconditioning and collateral growth. These processes are interrogated with a range of in-vitro and in-vivo models and include parallel descriptive studies in patients.
Areas of interest include:
The role of p38-mitogen-activated protein kinase in ischaemia/reperfusion injury
A number of studies have addressed the role of this kinase during ischaemia and reperfusion using the pharmacological inhibitor SB203580. This agent is known to have non-specific effects. We have generated adenoviruses where the SB203580 binding-site within p38-MAPK has been mutated to prevent binding. Using these agents we have shown that the anti-ischaemic properties of SB203580 are mediated through the alpha isoform of p38-MAPK rather than through other isoforms or kinases. These observations have been confirmed by using other adenoviral vectors encoding active and kinase-dead forms of p38-MAPK. Current studies concentrate on the mechanisms and consequences of p38-MAPK using these reagents together with a variety of targeted mouse lines.
Adaptation to angina in patients (Simon Redwood)
We are interested in the adaptation that occurs during serial occlusion of a coronary artery during percutaneous coronary intervention and during serial episodes of exertion. Studies to date have concentrated on discerning whether or not these adaptive phenomena are related to the recruitment of myocardial collaterals following the initial episode of angina. Our findings clearly indicate that collateral support, though variable between individuals is not responsible for these forms of adaptation. In a spin off project we are also determining the circulating factors that are associated with the variability in coronary collateral support. Having documented the magnitude and pattern of adaptation during serial coronary occlusion we are currently trying to gain mechanistic insights by attempting to block this phenomenon with reagents that interfere with the signalling processes that are known to be involved in the laboratory phenomenon of ischaemic preconditioning.
The role of cytokines in adaptation to ischaemia (Richard Heads)
Our interest is in determining how the inflammatory cytokines which are elevated in ischaemic heart disease interact with, and activate many of the proteins implicated in cardiac protection. Particular focus is on the interaction between protein kinases, calcineurin and COX-2.
The detection of post-translational modifications induced by oxidative stress (Phil Eaton)
We have developed a number of techniques specific to various oxidant-induced alterations within the cardiac proteome. These techniques are being used to understand the selectivity and consequences of these changes under a variety of pathophysiologically-relevent circumstances.
Dr ED Martin
Dr G Felice de Nicola
Dr R Tyther
Clinical Research Fellows
Dr K Asrress
Dr A Myat
Dr R Williams
Ms P Arabacilar
Ms E Smith
Mr D Thapa