Professor Manuel Mayr MD PhD
Professor of Cardiovascular Proteomics
The James Black Centre
King's College, University of London
125 Coldharbour Lane,
London SE5 9NU, UK
Phone: +44 (0) 20 7848 5132
Fax: +44 (0) 20 7848 5296
Prof. Manuel Mayr qualified in Medicine from the University of Innsbruck (Austria) in 1999, where he graduated “sub ausspiciis praesidentis”, the highest distinction awarded for academic education. He soon decided that his interests lay in research and therefore took up full-time research training in 2001, when he moved to St George’s Hospital Medical School to undertake a PhD with Professor Qingbo Xu. His PhD was awarded by the University of London in 2005, on the topic of “Cardiovascular Proteomics: Linking Proteomic and Metabolomic Changes”. He obtained a BHF Intermediate Research Fellowship in 2005 and in 2006 moved to King’s College London as Lecturer in the Cardiovascular Division. In 2008, he was successful in obtaining a BHF Senior Research Fellowship and this was recently renewed for a second term. In parallel, he achieved promotion to Senior Lecturer in 2008, to Reader in 2010, and to Professor in 2011.
His academic achievements have been recognised by the inaugural Michael Davies Early Career Award of the British Cardiovascular Society (2007), the inaugural Bernard and Joan Marshall Research Excellence Prize of the British Society for Cardiovascular Research (2010), and the Outstanding Achievement Award by the European Society of Cardiology Council for Basic Cardiovascular Science (2013).
Proteomics and Metabolomics Combined with Genetic Manipulation.
To understand complex biological systems, detailed examination of the properties of their constituent parts is essential, but insufficient. A single gene mutation can cause alterations of seemingly unrelated biochemical pathways. By combining proteomics and metabolomics in animal models of cardiovascular research, we try to bridge the gap between molecular and systems biology.
Stem Cell Differentiation into Vascular Cells.
Stem cell research holds great promise for regenerative medicine and tissue engineering. Our current studies focus to decipher the distinguishing proteomic and metabolic features of stem cell-derived cardiovascular cells. The overall aim is to identify key proteins or small molecules, that may be drug targets for promoting stem cell differentiation or novel paracrine factors leading to arterio- and angiogenesis.
Figure 1: Changes in protein expression of wildtype and apoE-deficient smooth muscle cells as shown by difference in-gel electrophoresis (DIGE).
Figure 2: Mass Spectrometry - Dionex Ultimate 3000 HPLC
BHF Intermediate Research Fellow
- Dr J Barallobre-Barreiro
- Dr K Dudek
- Ms S Langley
- Dr U Mayr
- Dr P Skroblin
- Dr X Yin
- Ms P Gyambibi-Barnett
- Dr Gonca Suna
- Dr Temo Barwari
- Ms Ferheen Baig