Professor Manuel Mayr MD PhD
Professor of Cardiovascular Proteomics
The James Black Centre
King's College, University of London
125 Coldharbour Lane,
London SE5 9NU, UK
Phone: +44 (0) 20 7848 5132
Fax: +44 (0) 20 7848 5296
Prof Manuel Mayr received his first degree in medicine from the University of Innsbruck, Austria, where he graduated “sub ausspiciis presidentis rei publicae”, the highest distinction awarded for academic education. From 1996-1998 he worked with Prof. Georg Wick at the Institute of Experimental Pathology, Innsbruck, Austria on the role of heat shock proteins in atherosclerosis. Beginning his postdoctoral studies, he joined Prof. Qingbo Xu’s group at the Institute of Biomedical Aging Research of the Austrian Academy of Sciences, working in the area of animal models and cellular signalling in response to biomechanical stress. In 2001, he moved together with Prof. Xu to London. At St. George’s, he developed his proteomic skills and obtained his PhD, entitled “Cardiovascular proteomics: Linking proteomic and metabolomic changes” from the University of London in 2005. In 2006, he spent a sabbatical in Prof. Peipei Ping’s laboratory at the University of California, Los Angeles, to further advance his skills in mass spectrometry. He is now in charge of the new proteomics facility at the James Black Centre that will provide a technology platform for cardiovascular research (www.vascular-proteomics.com).
Prof Mayr is a member of the Editorial Board for Proteomics - Clinical Applications and was recently appointed as Associate Editor for the Journal of Molecular and Cellular Cardiology. He is serving on the American Heart Association Program Committee (Council on Functional Genomics & Translational Biology) and the Management Committees of the British Atherosclerosis Society (BAS), the British Society for Proteome Research (BSPR) and the London Vascular Biology Forum (LVBF).
Proteomics and Metabolomics Combined with Genetic Manipulation.
To understand complex biological systems, detailed examination of the properties of their constituent parts is essential, but insufficient. A single gene mutation can cause alterations of seemingly unrelated biochemical pathways. By combining proteomics and metabolomics in animal models of cardiovascular research, we try to bridge the gap between molecular and systems biology.
Stem Cell Differentiation into Vascular Cells.
Stem cell research holds great promise for regenerative medicine and tissue engineering. Our current studies focus to decipher the distinguishing proteomic and metabolic features of stem cell-derived cardiovascular cells. The overall aim is to identify key proteins or small molecules, that may be drug targets for promoting stem cell differentiation or novel paracrine factors leading to arterio- and angiogenesis.
Figure 1: Changes in protein expression of wildtype and apoE-deficient smooth muscle cells as shown by difference in-gel electrophoresis (DIGE).
Figure 2: Mass Spectrometry - Dionex Ultimate 3000 HPLC
BHF Intermediate Research Fellow
Dr J Barallobre-Barreiro
Dr K Dudek
Ms S Langley
Dr U Mayr
Dr P Skroblin
Dr X Yin
Ms P Gyambibi-Barnett
Dr Gonca Suna