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James E Clark PhD

Reader in Applied & Human Physiology

Dr James Clark has a degree in Applied Biology from the University of Bath and a PhD completed at the Northwick Park Institute for Medical Research (Harrow, UK). Working on the processes involved in ischaemic and pharmacological preconditioning during his PhD and subsequent post doctoral research he was part of the team to develop novel carbon monoxide releasing molecules (CORMs) which can be used to elucidate the functional role of carbon monoxide in biological systems and led to the formation of the start-up company (HemoCORM).

In 2003 he was appointed a Research Associate in the Cardiovascular Division at King’s where he joined the group of Prof. Mike Marber and continued research on cardiac-protection and pharmacological preconditioning. In 2007, after a 4 year Research Associate position in the Cardiovascular Division at King’s, Dr Clark was awarded a British Heart Foundation (BHF) Intermediate Research Fellowship to carry out work on carbon monoxide-mediated cardio-protection. In February 2010, he was appointed to a Lectureship in Applied & Human Physiology (Aerospace Physiology) within the academic department of Physiology and teaches on the undergraduate and masters’ degree course in physiology. Dr Clark was promoted to Reader in Applied & Human Physiology in 2019. 

Dr Clark’s research interests involve the application of both in vivo and in vitro physiological and molecular techniques to investigate the response of the myocardium to the stresses of ischaemia, reperfusion and trophy. His interests in cardiac physiology lead to a fruitful collaboration with Scisence Inc. in Canada whereby he acted as a consultant in the development of new invasive catheters for assessing cardiac contractility. He is currently involved in a research contract with Omeros Corp. (CA) investigating the involvement of MASP-2 in protection of the heart against infarction and is running a pre-clinical trial in his lab using agents provided by Omeros Corp. In the future, Dr Clark hopes to be able to help run specialised courses in models of cardiovascular disease.

Dr David A Green

Lecturer in Human & Aerospeace Physiology
Coordinator, Aerospace & Extreme Environment Adaptation Group, Centre of Human & Aerospace Physiological Sciences (CHAPS)
Programme Director, Space Physiology & Health MSc

Dr David Green’s research is multi-disciplinary across a range of human physiological systems. Physiology is usually referred to as the processes that act to ensure bodily homeostasis. However, he is interested in the physiological responses and adaptation that occur both within, and between physiological systems in times of change. Particular interest is held in the physiological adaptations seen during exposure to extreme/hostile environments, with an eye to mechanistic elucidation, technological intervention development and terrestrial clinical application.

These interests, his research-led teaching and advocacy of UK engagement in Manned Space Flight with a view to terrestrial application of biomedical advances, reflect his diverse scientific experiences.

Having obtained a PhD from the Centre for Exercise Neuroscience at London South Bank University, Dr Green undertook post-doctoral work with Professors Adolfo Bronstein and Michael Gresty at Imperial College London. He then worked in South India for a year with the Family Planning Association India – Madurai, and Peoples Watch Tamil Nadu investigating medico-legal human rights issues surrounding HIV care and torture.

After briefly returning to Imperial College London in 2007 he took up his current appointment at King’s, initially as a Cardiorespiratory Physiologist, although his remit rapidly expanded to include Aerospace, and then Space Physiology. In 2009, he was a visiting scientist within the Crew Medical Support Office at the European Astronaut Centre (Cologne; Germany).

Of his varied research interests, he says that ‘they stem both from a desire to derive mechanistic physiological knowledge, but also for the development and validation of interventions that can support, preserve or improve human performance in health and disease, and in hostile environments, on Earth and in Space.’

Dr Green is a member of the International Academy of Astronautics, the (UK) Physiological Society and is an executive member of the UK Space Biomedical Association.

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