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Dr Sarah Barry

Sarah-BarrySenior Lecturer in Chemical Biology

 Email: sarah.barry@kcl.ac.uk

 Tel: +44 (0)20 7848 1760

 Address: Department of Chemistry          King's College London                                Room 117, Britannia House
 7 Trinity Street
 London SE1 1DB

 

 

Biography

Sarah Barry received her undergraduate degree in chemistry from University College Dublin (UCD). She stayed in UCD to carry out a PhD in chemistry under the supervision of Dr. Peter Rutledge in which she worked towards the synthesis and development of novel iron complexes to mimic the action of the non-heme iron dependent enzymes, Rieske dioxygenases. She spent the final year of her PhD studies at the University of Sydney. She joined the Challis group as a postdoctoral research fellow in 2007, and later a BBSRC researcher co-investigator to work on the enzymology of natural product biosynthesis focusing on novel enzymes in the thaxtomin biosynthetic pathway in Streptomyces scabies. She joined the Department of Chemistry at King’s College London as a Lecturer in Chemical Biology in July 2012.

Research Interests

My group focuses on understanding and exploiting the biosynthetic capacity of microbes, towards the discovery of novel bioactive compounds and biocatalysts. To study these complex pathways and understand the chemistry behind them, we combine synthetic and analytical chemistry, microbiology and biochemistry. 

Dr Barry's Research Portal 

Research Group: Barry

Sarah Barry's group focuses on understanding and exploiting the biosynthetic capacity of microbes, towards the discovery of novel bioactive compounds and biocatalysts. This involves investigating the conditions under which biosynthetic pathways are expressed in bacteria, as well as elucidating the mechanisms of the enzymes involved in the biosynthesis of natural products.

Barry Research Page

Selected Publications
  • Barry, S. M.; Challis, G. L. Mechanism and Catalytic Diversity of Rieske Oxygenases ACS Catalysis 2013, 3, 2362.
  • Barry, S. M.; Kers, J. A.; Johnson, E. R.; Song, L.; Aston, P. R.; Patel, B.; Krasnoff, S. B.; Gibson, D. M.; Loria, R.; Challis, G. L. Cytochrome P450-catalysed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. Nat. Chem. Biol. 2012, 8, 814. (Featured in Chemistry & Industry 2012, 76, 11.)
  • Barry, S. M.; Mueller-Bunz, H.; Rutledge, P. J. Investigating the cis-dihydroxylation of alkenes by non-heme iron enzyme mimics Org. Biomol. Chem. 2012, 10, 7372.
  • Sydor, P. K.; Barry, S. M.; Odulate, O. M.; Barona-Gomez, F.; Haynes, S. W.; Song, L.; Challis, G. L. Regiodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nat. Chem. 2011, 3, 342. (Highlighted in News and Views Nat. Chem. 2011, 3, 388).
  • Davis, C.; Carberry, S.; Schrettl, M.; Singh, I.; Stephens, J. C.; Barry, S. M.; Kavanagh, K.; Challis, G. L.; Brougham, D.; Doyle, S. The role of glutathioneS-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus Chem. Biol. 2011, 18, 542.
  • Barry, S. M.; Challis, G. L. Recent advances in siderophore biosynthesis.Curr. Opin. Chem. Biol. 2009, 13, 205.
  • McManus, H. A.; Barry, S. M.; Andersson, P. G.; Guiry, P. J. Preparation of pyrrolidine-oxazoline containing ligands and their application in asymmetric transfer hydrogenation. Tetrahedron 2004, 60, 3405.

 

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