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Dr Kogularamanan (Rama) Suntharalingam

Rama-Suntharalingam

Leverhulme Research Fellow in BioInorganic Chemistry

Email: kogularamanan.suntharalingam@kcl.ac.uk

Tel: +44 (0)20 7848 2595

Address: Department of Chemistry            King's College London                                  Room 115, Britannia House                             7 Trinity Street                                                                                                          London SE1 1DB 

 
Biography

Rama obtained a MSci degree in Chemistry from Imperial College London (UK) in 2008. Rama's first taste of research came in Prof. Mike Hill's laboratory as an UROP student. This experience proved inspiring, and encouraged Rama to undertake further research. Rama was awarded his PhD in Chemistry from Imperial College London (UK) in 2012. His PhD research was carried out under the mentorship of Prof. Ramon Vilar. Upon completion of his PhD, Rama joined Prof. Stephen J. Lippard's research group at Massachusetts Institute of Technology (MA, USA). He was awarded the Misrock Postdoctoral Fellowship by the Koch Institute of Integrative Cancer Research, MIT in 2012. He was then awarded the Dalton Young Researchers Award by the Royal Society of Chemistry in 2014 “for his contributions to the design and development of new metallo-pharmaceuticals and to the understanding of their complex mechanisms of action.” In the same year he began his independent research group at King’s College London. He is funded by a Leverhulme Early Career Fellowship. His current research combines facets of inorganic chemistry, nanotechnology, and molecular biology.

Research Interests

Cancer is one of the leading causes of death and suffering throughout the world and continues to impose a huge socio-economic burden on society. According to the latest statistics released by the World Health Organisation, an estimated 8.2 million cancer-related deaths occurred in 2012, a 0.6 million increase from the previous estimation in 2008. With the global cancer burden rising, the development of new cancer treatments is crucial. Platinum based drugs, cisplatin, carboplatin, and oxaliplatin make up the first line of defence against many systemic malignancies. Drawbacks associated with platinum therapy, such as acquired or inherent resistance, toxic side effects, and tumour recurrence after initial treatment, have prompted researchers to investigate alternative transition metal-based anticancer drugs. The Suntharalingam research group aims to use the structural, optical, redox, magnetic, and catalytic diversity offered by metal-containing small molecules to design and develop new generations of metallo-pharmaceuticals for the treatment of cancer and other diseases. The group also focuses on engineering new nano-material systems to deliver therapeutics to their site(s) of action.

Dr Suntharalingam's Research Portal 

Research Group: Suntharalingam

Kogularaman (Rama) Suntharalingam's group aims to use the structural, optical, redox, magnetic, and catalytic diversity offered by metal-containing small molecules to design and develop new generations of metallo-pharmaceuticals for the treatment of cancer and other diseases. The group also focuses on engineering new nano-material systems to deliver therapeutics to their site(s) of action.

Suntharalingam Research Page 

Selected Publications
  • Suntharalingam K, Johnstone TC, Bruno PM, Lin W, Hemann MT, Lippard SJ, “Bidentate Ligands on Osmium(VI) Nitrido Complexes Control Intracellular Targeting and Cell Death Pathways” Journal of the American Chemical Society, 2013, 135 (38), 14060-14063
  • Suntharalingam K, Lin W, Johnstone TC, Bruno PM, Zheng Y, Hemann MT, Lippard SJ, “A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex” Journal of the American Chemical Society, 2014, 136 (41), 14413–14416
  • Suntharalingam K, Ying S, Lippard SJ, “Conjugation of Vitamin E Analog α-TOS to Pt(IV) Complexes for Dual-Targeting Anticancer Therapy” Chemical Communications,  2014, 50, 2465-2468
  • Suntharalingam K, Wilson JJ, Lin W, Lippard SJ, “A Dual-targeting, p53-Independent, Apoptosis Inducing Platinum(II) Anticancer Complex, [Pt(BDIQQ)]Cl”, Metallomics, 2014, 6(3), 437-443
  • Zheng Y, Suntharalingam K, Johnstone TC, Yoo H, Lin W, Brooks JG, Lippard SJ, “Pt(IV) Prodrugs Designed to Bind Human Serum Albumin for Drug Delivery” Journal of the American Chemical Society, 2014, 136 (24), 8790–8798
  • Zheng Y, Suntharalingam K, Johnstone TC, Lippard SJ, “Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery” Chemical Science, 2014 DOI: 10.1039/c4sc01892c

 

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