Ageing Research at King’s (ARK) is a cross-faculty multidisciplinary consortium which brings together scholarship, research, innovation and entrepreneurship in ageing across the life course in several complementary fields. ARK is a leading industry-academic R&D hub for personalised and preventive diagnostics, prognostics and therapeutics, and represents King’s world class excellence for research on the biology of ageing, from the basic mechanisms in biogerontology to clinical translation and the social impact of ageing to better inform global policy makers.
The primary purpose of ARK is to enhance multidisciplinary research collaborations within King’s and our external global academic and industry partners to better understand the mechanisms of ageing and to improve health-span and longevity in the community. ARK is uniquely positioned to address the challenges of an ageing world, and to provide answers at multiple levels, from cellular mechanisms and regenerative therapies to social sciences, influencing government policies, consumer industries and clinical research. Our network within King's includes the recently established Centre for Ageing Resilience In a Changing Environment (CARICE) and will incorporate elements of the new multidisciplinary education and research programmes being developed at King's. ARK hosts a series of talks and symposia on ageing and healthy longevity - selected events are listed under the Activities tab below.
People
Director, Centre for Healthy Brain Ageing
ARK Innovation Advisor
TransCampus Dean
Senior Lecturer (Associate Professor) in Strategic Marketing
Professor of Population and Digital Health Sciences
ARK Executive Advisor
Themes
Ageing, Resilience and Society
Established research programme with strong emphasis on multidisciplinary and multiagency work, research on Ageing & Society at King’s is led by the Institute of Gerontology and Centre for Global Ageing. Together with the new Centre for Ageing Resilience in a Changing Environment, research focuses on broad topics ranging from the social and economic factors associated with the ageing through to the psychological, biomedical and global aspects of ageing demographics.
Clinical Research and Practice
Through world leading expertise across King's Health Partners and the Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, ARK undertakes clinical research in the treatment and care of individuals with age-related diseases, including cancer, rheumatoid arthritis, cardiovascular disease and stroke. Aiming to achieve the best possible quality of life for patients and their families, and includes geriatric medicine, control of pain as well as attention to psychological, social considerations in the elderly.
Mechanisms of Biological Ageing
Multidisciplinary basic and clinical research environment to elucidate the mechanisms of age-related conditions such as dementia, cardiovascular disease, inflammation and frailty - from cell and molecular biology to physiological, epigenetics, nutrition and microbiome studies in man - this synergistic approach facilitates development of interventions for multi-morbidity in ageing societies and enhanced healthy longevity.
Care of the Elderly
Research across several departments at King's focuses on social and clinical research on living well with frailty, dementia communication and improving care experiences in older people. Discovery and innovation to create knowledge and impact nursing, midwifery, and healthcare policy and practice, as well as how we educate those providing care of the elderly. The Cicely Saunders Institute is the first purpose built institute for research into palliative care, policy and rehabilitation.
Healthy Brain Ageing
The Institute of Psychiatry, Psychology and Neuroscience focuses on the ageing brain and associated mental health. Research includes the molecular mechanisms and discovery of novel therapies for neurodegeneration, maintenance of mental wellness, Parkinson’s and Alzheimer’s diseases, depression, psychoses, sleep, neuroimaging and digital health informatics. Centres of excellence include the UK Dementia Research Institute and the Wolfson Centre for Age Related Diseases. Commercial collaborations are facilitated through the Centre for Innovative Therapeutics.
Oral Health
The Faculty of Dentistry, Oral and Craniofacial Sciences at King's has a number of ARK affiliated groups has a broad portfolio oral health research directed towards ageing populations, from basic science, through to transnational research, public health and social & behavioural sciences. Focusing on mouth as an ecosystem, the role of saliva, taste sensation and oral microbiome known to be affected by ageing.
AI in Ageing Research and Healthy Longevity
Ues of AI technologies within longevity and ageing research is increasing in both academia and industry. To utilise the latest AI advances and accelerate innovation and technology transfer, ARK has partnered with the King's AI Centre for Value Based Healthcare and our industry partners Insilico Medicine and Deep Longevity to establish a Longevity AI Consortium. Machine learning is used to develop longevity and ageing predictors offer new possibilities for diverse data types. This will enable a holistic view aiming to identify novel longevity and healthy ageing biomarkers, accelerate diagnosis of age-related diseases, refine demographic and clinical methods, develop personalised interventions to promote lifestyles for healthy longevity.
Economics of Healthy Ageing
Together with King's Business School, ARK researchers are developing an international network focusing on financial longevity and the economic burden of a global changing population demographics through innovation and opportunities for enhancing productivity of the ageing workforce. We are working with global corporate partners in the pharma, food, insurance and consumer goods sectors to address these issues and to develop commercialization opportunities.
Industry Engagement
The Unilever Bioscience Innovation Hub at King's established in 2020 provides a centre of expertise building on the strengths of the Unilever Framework Agreement. The Hub has bought Unilever researchers and King’s academics together to focus on research in personal care, human biology, microbiology and healthy ageing. Over the last 10 years the Unilever partnership has leveraged over £5m in funding for collaborative projects across King's.
Entrepreneurship in Healthy Longevity
ARK is uniquely placed to have an Entrepreneur in Residence based in the Department of Informatics at King's focusing on Human Centred Computing, Data Sciences and Digital Health. The King's Entrepreneurship Institute also offers students and researchers support in innovation and commercialization opportunities to tackle novel approaches to enhance healthy longevity.
Integrative Medicine for Healthy Ageing
The King's Centre for Integrative Chinese Medicine is a multidisciplinary research initiative across several faculties at KCL and King's Health Partners which aims to integrate traditional Chinese medicine (TCM) and alternative therapies from other regions with conventional clinical practice.
Longevity Policy and Governance
ARK is a founding member of the All Party Parliamentary Group (APPG) for Longevity and hosted the launch of "Health of the Nation: National Strategy for Healthier Longer Lives" report in February 2020. ARK continues to support the APPG through the Open Life Data Framework and Business for Health initiatives. The Policy Institute at King's provides evidence and expertise to inform global policy and practice in healthy ageing.
Publications
Selected ageing research publications from across King's:
Lifespan investigation of brain volumetric changes associated with substance use disorders
Lin, X., Shi, R., Xiang, S., Alnæs, D., Chen, D., Zheng, C., Banaschewski, T., Barker, G., Bokde, A., Desrivières, S., Flor, H., Garavan, H., Gowland, P., Grigis, A., Heinz, A., Martinot, J.-L., Martinot, M.-L., Artiges, E., Nees, F. & Orfanos, D. P. & 12 others, Poustka, L., Smolka, M., Hohmann, S., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Sahakian, B., Westlye, L. T., Robbins, T., Jia, T. & Feng, J., 26 Jun 2025, In: Nature Mental Health .Research output: Contribution to journal › Article
Transforming Geriatric Care: The Role of Remote Sensing Technologies in Nursing for Older Adults
Horta Reis Da Silva, T., 16 Jul 2025, Remote Sensing for Environmental Monitoring. Saritha, V., Pande, C. B., Singh, R. & Shahid, M. (eds.). SPRINGERNATURE, p. 95-119 25 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Exploring the use of musical activities implemented in home-based dementia care as part of the HOMESIDE study
Crabtree, S., Baker, F. A., Bukowska, A. A., Hsu, M.-H., Kvamme, T., McMahon, K., Odell-Miller, H., Sousa, T., Stensæth, K., Wosch, T. & Tamplin, J., 2 Jul 2025, In: Arts and Health.Research output: Contribution to journal › Article › peer-review
Human development, inequality, and their associations with brain structure across 29 countries
Medel, V., Alliende, L. M., Bethlehem, R. A. I., Seidlitz, J., Ringlein, G., Arango, C., Arnatkeviciute, A., Asmal, L., Bellgrove, M. A., Benegal, V., Bernardo, M., Billeke, P., Jorge, B.-B., Bressan, R., Busatto Filho, G., Castro, M., Chaim-Avancini, T. M., Costanzi, M., Czepielewski, L. S. & Dazzan, P., 16 Jul 2025, (E-pub ahead of print) In: European Psychiatry.Research output: Contribution to journal › Article › peer-review
Land Restoration Amid Male Outmigration: The Cases of Burkina Faso and Kenya
Langill, J. C., Crossland, M., Elias, M., Vinceti, B., Paez Valencia, A. M., Traoré, A. & Traoré, D., 1 Dec 2023, In: Ecological Restoration. 41, 4, p. 220-235Research output: Contribution to journal › Article › peer-review
Gendered effects of migration on social organization and smallholder production in Oubritenga Province, Burkina Faso
Langill, J. C., Elias, M., Vinceti, B., Traoré, A. & Traoré, D., 4 Feb 2023, In: Journal of Rural Studies. 98, p. 19-33Research output: Contribution to journal › Article › peer-review
Neoadjuvant chemotherapy in relation to long-term mortality in individuals cured of gastric adenocarcinoma
Leijonmarck, W., Mattsson, F. & Lagergren, J., 31 Jan 2025, In: Gastric Cancer. 28, 1, p. 96-101 6 p.Research output: Contribution to journal › Article › peer-review
Prenatal and progressive coenzyme Q10 administration to mitigate muscle dysfunction in mitochondrial disease
Hernández-Camacho, J. D., Vicente-García, C., Ardila-García, L., Padilla-Campos, A., López-Lluch, G., Santos-Ocaña, C., Zammit, P. S., Carvajal, J. J., Navas, P. & Fernández-Ayala, D. J. M., Dec 2024, In: Journal of cachexia, sarcopenia and muscle. 15, 6, p. 2402-2416 15 p.Research output: Contribution to journal › Article › peer-review
Prediction model for postoperative pulmonary complications after thoracoscopic surgery with machine learning algorithms and SHapley Additive exPlanations
Wang, S., Lin, Y., Shi, H., Liang, P., Luo, Z., Kong, J., Huang, J., Cheng, M., Zhang, B., Wang, Y., Kan, H., Liang, L. & Xie, W., 30 Jun 2025, In: Journal of Thoracic Disease. 17, 6, p. 3603-3618 16 p.Research output: Contribution to journal › Article › peer-review
Tooth loss, diet quality, and cognitive decline: A 15-year longitudinal study
Winning, L., Logan, D., McEvoy, C. T., Farsi, D., McKay, G. J., Patterson, C. C., Passmore, P., Holmes, C., Linden, G. J. & McGuinness, B., 27 Jun 2025, (E-pub ahead of print) In: The journal of nutrition, health & aging. 29, 9, 100620.Research output: Contribution to journal › Article › peer-review
Impact of age on the homing potential of 89 Zr-radiolabelled CD8+ T cells
Bystrom, J., Pereira Da Costa, M., Minino, A., Qureshi, A., Keeling, G. P., Pham, T. T., Sunassee, K., Carroll, E., Garrod-Ketchley, C., Schroth, J., Tsang, V., T. M. de Rosales, R., Terry, S. Y. A. & Henson, S. M., 3 Jul 2025, (E-pub ahead of print) In: Scientific Reports. 15, 1, 23801 .Research output: Contribution to journal › Article › peer-review
Assessment of frailty in patients with heart failure: A new Heart Failure Frailty Score developed by Delphi consensus
Vitale, C., Berthelot, E., Coats, A. J. S., Loreena, H., Albert, N. M., Tkaczyszyn, M., Adamopoulos, S., Anderson, L., Anker, M. S., Anker, S. D., Bell, D., Ben-Gal, T., Bistola, V., Bozkurt, B., Brooks, P., Camafort, M., Carrero, J. J., Chioncel, O., Choi, D.-J. & Chung, W.-J. & 41 others, Doehner, W., Fernández-Bergés, D., Ferrari, R., Fiuzat, M., Gomez-Mesa, J. E., Gustafsson, F., Jankowska, E., Kang, S.-M., Kinugawa, K., Khunti, K., Hobbs, F. D. R., Lee, C., Lopatin, Y., Maddocks, M., Maltese, G., Marques-Sule, E., Matsue, Y., Miró, Ò., Moura, B., Piepoli, M., Ponikowski, P., Pulignano, G., Rakisheva, A., Ray, R., Sciacqua, A., Seferovic, P., Sentandreu-Mañó, T., Sze, S., Sinclair, A., Strömberg, A., Theou, O., Tsutsui, H., Uchmanowicz, I., Vidan, M. T., Volterrani, M., von Haehling, S., Yoo, B., Zhang, J., Zhang, Y., Metra, M. & Rosano, G. M. C., Jun 2025, In: ESC Heart Failure. 12, 3, p. 1818-1831 14 p.Research output: Contribution to journal › Article › peer-review
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
Saeedi Saravi, S. S., Pugin, B., Constancias, F., Shabanian, K., Spalinger, M., Thomas, A., Le Gludic, S., Shabanian, T., Karsai, G., Colucci, M., Menni, C., Attaye, I., Zhang, X., Allemann, M. S., Lee, P., Visconti, A., Falchi, M., Alimonti, A., Ruschitzka, F. & Paneni, F. & 1 others, Beer, J. H., Jun 2025, In: Nature Aging. 5, 6, p. 1025-1045 21 p.Research output: Contribution to journal › Article › peer-review
Risk factors for depressed mood amongst a community dwelling older age population in England: Cross-sectional survey data from the PRO-AGE study
Biddulph, J. P., Iliffe, S., Kharicha, K., Harari, D., Swift, C., Gillmann, G. & Stuck, A. E., 23 Jan 2014, In: BMC Geriatrics . 14, 1, 5.Research output: Contribution to journal › Article › peer-review
Associations between different measures of SARS-CoV-2 infection status and subsequent economic inactivity: A pooled analysis of five longitudinal surveys linked to healthcare records
Shaw, R. J., Hamilton, O. K. L., Rhead, R., Silverwood, R. J., Wels, J., Zhu, J., Di Gessa, G., Bowyer, R. C. E., Moltrecht, B., Green, M. J., Demou, E., Pattaro, S., Zaninotto, P., Boyd, A., Greaves, F., Chaturvedi, N., Ploubidis, G. B. & Katikireddi, S. V., 9 Apr 2025, (E-pub ahead of print) In: PLoS ONE. 20, 4 April, e0321201.Research output: Contribution to journal › Article › peer-review
Meaningful volunteer involvement in adult social care (ASC): Perspectives from diverse ASC providers, key informants, and evaluation of the NHS and Care Volunteer Responders scheme
Kharicha, K., Leverton, M., Owen, J., Norrie, C., Burch, T. & Hickman, B., 26 Jun 2025, London: NIHR Policy Research Unit in Health and Social Care Workforce, The Policy Institute, King's College London. 57 p.Research output: Book/Report › Commissioned report › peer-review
Parental death in childhood and stock market participation: Cross-cultural insights
Wang, Y., Driouchi, T. & Nguyen, D. D., Aug 2025, In: Journal of Economic Behavior and Organization. 236, 107078.Research output: Contribution to journal › Article › peer-review
Lifespan investigation of brain volumetric changes associated with substance use disorders
IMAGEN Consortium, 28 May 2025, In: MedRxiv.Research output: Contribution to journal › Article
Single-Subject Network Analysis of FDOPA PET in Parkinson's Disease and Psychosis Spectrum
FDOPA PET Imaging Working Group Consortium, 12 Jun 2025, (E-pub ahead of print) In: Human Brain Mapping. 46, 8, p. e70253 e70253.Research output: Contribution to journal › Article › peer-review
Does a palliative medicine service reduce hospital length of stay and costs in adults with a life-limiting illness?-a difference-in-differences evaluation of service expansion in Ireland
Matthews, S., Hurley, E., Johnston, B. M., Kane, P., Ryan, K., Tiernan, E., Normand, C. & May, P., 22 Jul 2024, In: Annals of Palliative Medicine. 13, 4, p. 766-777 12 p.Research output: Contribution to journal › Article › peer-review
Cohort profile. characterisation, determinants, mechanisms and consequences of the long-term effects of COVID-19 - providing the evidence base for health care services (CONVALESCENCE) in the UK
Jamieson, A., Saikhan, L. A., Raman, B., Alghamdi, L., Conde, P., Dobson, R., Fernández-Sanlés, A., Folarin, A., Goudswaard, L. J., Hamill Howes, L., Jones, S., Neubauer, S., Orini, M., Pierce, I., Ranjan, Y., Rapala, A., Smith, S. M., Sudre, C., Thompson, E. J. & Wild, J. & 6 others, Williams, D., Wong, A., Steves, C. J., Timpson, N., Chaturvedi, N. & Hughes, A., 5 Jun 2025, In: BMJ Open. 15, 6, e094760.Research output: Contribution to journal › Article › peer-review
An Agenda for the Medical Humanities and Ageing
Zimmermann, M., 2025, (Accepted/In press) In: History of the Human Sciences.Research output: Contribution to journal › Article › peer-review
Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization
Qian, S., Ugurlu, D., Fairweather, E., Toso, L. D., Deng, Y., Strocchi, M., Cicci, L., Jones, R. E., Zaidi, H., Prasad, S., Halliday, B. P., Hammersley, D., Liu, X., Plank, G., Vigmond, E., Razavi, R., Young, A., Lamata, P., Bishop, M. & Niederer, S., 16 May 2025, (E-pub ahead of print) In: Nature Cardiovascular Research. 4, 5, p. 624-636 13 p., 11437.Research output: Contribution to journal › Article › peer-review
The expanding clinical and genetic spectrum of DYNC1H1-related disorders
Möller, B., Becker, L. L., Saffari, A., Afenjar, A., Coci, E. G., Williamson, R., Ward-Melver, C., Gibaud, M., Sedláčková, L., Laššuthová, P., Libá, Z., Vlčková, M., William, N., Klee, E. W., Gavrilova, R. H., Lévy, J., Capri, Y., Scavina, M., Körner, R. W. & Valivullah, Z. & 36 others, Weiß, C., Möller, G. M., Frazier, Z., Roberts, A., Gener, B., Scala, M., Striano, P., Zara, F., Thiel, M., Sinnema, M., Kamsteeg, E. J., Donkervoort, S., Duboc, V., Zaafrane-Khachnaoui, K., Elkhateeb, N., Selim, L., Margot, H., Marin, V., Beneteau, C., Isidor, B., Cogne, B., Keren, B., Küsters, B., Beggs, A. H., Sveden, A., Chopra, M., Genetti, C. A., Nicolai, J., Dötsch, J., Koy, A., Bönnemann, C. G., von der Hagen, M., von Kleist-Retzow, J. C., Voermans, N. C., Jungbluth, H. & Dafsari, H. S., 1 Feb 2025, In: Brain. 148, 2, p. 597-612 16 p.Research output: Contribution to journal › Article › peer-review
DunedinPACNI estimates the longitudinal pace of aging from a single brain image to track health and disease
Whitman, E. T., L Elliott, M., Knodt, A. R., Abraham, W. C., Anderson, T. J., Cutfield, N. J., Hogan, S., Ireland, D., Melzer, T. R., Ramrakha, S., Sugden, K., Theodore, R., Williams, B. S., Caspi, A., Moffitt, T. & Hariri, A. R., 1 Jul 2025, (E-pub ahead of print) In: Nature Aging. 582.Research output: Contribution to journal › Article › peer-review
Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes
Troakes, C., Bodi, I., Pienaar, I., Stephenson, E., Bailey, L. J., Gentleman, S., Tuppen, H., Morris, C. M., Carr, T. M., Guthrie, S. & Elson, J. L., 6 Jun 2025, In: Ageing Cell. e70125.Research output: Contribution to journal › Article › peer-review
The impact of perceptual complexity on road crossing decisions in younger and older adults
Nicholls, V. I., Wiener, J., Meso, A. I. & Miellet, S., 4 Jan 2024, (E-pub ahead of print) In: Scientific Reports. 14, 1, 479.Research output: Contribution to journal › Article › peer-review
Conducting adult social care research in the United Kingdom – impacts of challenges to study processes on study feasibility.
Fitzpatrick, J. M., Worsley, P. R., Chatterton, C., Fader, M., Graham, T., Norton, C., Woodward, S. & Harris, R., 14 May 2025, (Accepted/In press) In: Age and Ageing.Research output: Contribution to journal › Article › peer-review
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Jacques, M., Landen, S., Sharples, A. P., Garnham, A., Schittenhelm, R., Steele, J., Heikkinen, A., Sillanpää, E., Ollikainen, M., Broatch, J., Zarekookandeh, N., Hanson, O., Ekström, O., Asplund, O., Lamon, S., Alexander, S. E., Smith, C., Bauer, C., Woessner, M. N. & Levinger, I. & 16 others, Teschendorff, A. E., Gillberg, L., Blom, I., Helge, J. W., Harvey, N. R., Haupt, L. M., Griffiths, L. R., Deshmukh, A. S., Pietiläinen, K. H., Piirilä, P., Seaborne, R. A. E., Klevjer, M., Bye, A., Wisløff, U., Jones-Freeman, B. & Eynon, N., 24 Jun 2025, In: Cell Reports. 44, 6, 115750.Research output: Contribution to journal › Article › peer-review
How many people will live and die with serious illness in Ireland to 2040? Estimated needs and costs using microsimulation
May, P., Normand, C., Smith, S., Moriarty, F., Ward, M., Ryan, K., Johnston, B. M., Romero-Ortuno, R., Kenny, R. A., Sean Morrison, R. & Tysinger, B., Oct 2024, In: Journal of the Economics of Ageing. 29, 100528.Research output: Contribution to journal › Article › peer-review
Projecting future health and service use among older people in Ireland: an overview of a dynamic microsimulation model in The Irish Longitudinal Study on Ageing (TILDA)
May, P., Normand, C., Matthews, S., Kenny, R. A., Romero-Ortuno, R. & Tysinger, B., 2022, In: HRB Open Research. 5, 21.Research output: Contribution to journal › Article › peer-review
Computational analysis of learning in young and ageing brains
Hewavitharana, J., Steinhofel, K., Giese, K. P., Ierardi, C. M. & Anand, A., 6 May 2025, In: Frontiers in Computational Neuroscience. 19, 1565660.Research output: Contribution to journal › Article › peer-review
Social support, cognition, and mental health among older people in China: A longitudinal life course study
Long, C., Yang, W. & Glaser, K., Sept 2025, In: Social Science & Medicine. 381, 118279.Research output: Contribution to journal › Article › peer-review
The epidemiology and burden of ten mental disorders in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021
Szucs, A., van der Lubbe , S. C., Arias de la Torre, J., Valderas, J. M., Hay, S. I., Bisignano, C., Morgan, B. W., GBD 2021 ASEAN Mental Disorders Collaborators, Murray, C. J. L., Santomauro, D. F. & Ng, M., Jun 2025, In: The Lancet Public Health. 10, 6, p. e480-e491Research output: Contribution to journal › Article › peer-review
Green Infrastructure Strategies for Ageing Populations: Enhancing Health and Well-Being Through Sustainable Urban Design
Horta Reis Da Silva, T., 16 May 2025, Sustainable Development Goals (SDG) and Its Intersection With Health and Well-Being. Poddar, S. & Ansar, W. (eds.). IGI Global Scientific Publishing, p. 207-232 26 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
Assary, E., Coleman, J., Hemani, G., Van De Weijer, M., Howe, L. J., Palviainen, T., Grasby, K. L., Ahlskog, R., Nygaard, M., Cheesman, R., Lim, K., Reynolds, C. A., Ordoñana, J. R., Colodro-Conde, L., Gordon, S. G., Madrid-Valero, J. J., Thalamuthu, A., Hottenga, J.-J., Mengel-From, J. & Armstrong, N. J. & 32 others, Sachdev, P., Lee, T., Brodaty, H., Trollor, J. N., Wright, M. J., Ames, D., Catts, V. S., Latvala, A., Vuoksimaa, E., Mallard, T. T., Harden, K. P., Tucker-drob, E. M., Oskarsson, S., Hammond, C. J., Christensen, K., Taylor, M. J., Lundström, S., Larsson, H., Karlsson, R., Pedersen, N. L., Mather, K. A., Medland, S. E., Boomsma, D. I., Martin, N. G., Plomin, R., Bartels, M., Lichtenstein, P., Kaprio, J., Eley, T., Davies, N. M., Munroe, P. B. & Keers, R., 10 Jun 2025, In: Nature Human Behaviour.Research output: Contribution to journal › Article › peer-review
Can long-term care insurance reduce catastrophic health and long-term care expenditures among older adults? A quasi-experimental study in China
Long, C., Yang, W. & Glaser, K., 3 Jun 2025, In: European Journal of Ageing. 22, 1, 25.Research output: Contribution to journal › Article › peer-review
Anthocyanin Supplementation in Adults at Risk for Dementia: A Randomized Controlled Trial on Its Cardiometabolic and Anti-inflammatory Biomarker Effects
Borda, M. G., Ramirez-Velez, R., Botero-Rodríguez, F., Baldera, J. P., De Lucia, C., Pola, I., Barreto, G. E., Khalifa, K., Bergland, A. K., Kivipelto, M., Cederholm, T., Zetterberg, H., Ashton, N. J., Ballard, C., Siow, R. & Aarsland, D., 2 May 2025, In: GeroScience. e71079.Research output: Contribution to journal › Article › peer-review
Forecasting the Global Burden of Peripheral Artery Disease from 2021 to 2050: A Population-Based Study
Deng, L., Du, C., Liu, L., Wang, Y., Gu, H., Armstrong, D. G., Mills, J. L., Hochlenert, D., Deng, H., Ran, J., Chen, Y., Jiang, X., Ma, Y., Chen, Q., Deng, W. & “Flow and Toe” Research Team (FORT), 1 Jul 2025, In: Research. 8, 0702.Research output: Contribution to journal › Article › peer-review
Computing with Biological Agents on Networks
Nicolau, D., 2025, (Accepted/In press) In: International Journal of Parallel, Emergent and Distributed Systems.Research output: Contribution to journal › Article › peer-review
Independent evaluation of an 11-CpG panel for age estimation in blood
Refn, M. R., Kampmann, M. L., Vyöni, A., Tfelt-Hansen, J., Sørensen, E., Ostrowski, S. R., Kongstad, M., Aliferi, A., Giangasparo, F., Morling, N., Ballard, D., Børsting, C. & Pereira, V., 31 Mar 2025, In: Forensic Science International: Genetics. 76, 103214.Research output: Contribution to journal › Article › peer-review
Protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery
Witard, O., Hughes, A., Morgan, P., Larsen, M., Herrod, P., Phillips, B. E. & Dhesi, J. K., 5 May 2025, (E-pub ahead of print) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
Integrating palliative care into primary care for older people with multimorbid serious illness: a multinational qualitative cross-sectional study in Sub-Saharan Africa
Nkhoma, K. B., Bates, M. J., van Breevoort, D., Chifamba, D. D., Evans, C. J., Kwaitana, D., Mensah, A. B. B., Mnenula, M. C., Mupaza, L., Opare-Lokko, E. B. A. & Harding, R., 23 Mar 2025, (E-pub ahead of print) In: BMJ Public Health. 3, 1, p. e001355Research output: Contribution to journal › Article › peer-review
Music Therapist’s use of singing, listening, playing instruments and movement with music to improve cognition and reduce neuropsychiatric symptoms in music therapy for people living with dementia
Crabtree, S., Hsu, M.-H., Pool, J. & Odell-Miller, H., 31 May 2025, In: British Journal of Music Therapy. 39, 1Research output: Contribution to journal › Article › peer-review
Best Practices for Implementing Electronic Care Records in Adult Social Care: Rapid Scoping Review
Snow, M., Ribeiro, W. S., Baginsky, M., Di Giorgio, S., Farrelly, N., Larkins, C., Poole, K., Steils, N., Westwood, J. & Malley, J., 14 Feb 2025, In: JMIR Aging. 8, e60107.Research output: Contribution to journal › Article › peer-review
Use of the Adult Social Care Outcomes Toolkit (ASCOT) in research studies: an international scoping review
Rand, S., Smith, N., Welch, E., Allan, S., Caiels, J. & Towers, A.-M., 18 Apr 2025, (E-pub ahead of print) In: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. e088685.Research output: Contribution to journal › Article › peer-review
Family Caregiver Perspectives on Digital Methods to Measure Stress: Qualitative Descriptive Study
Rose, L., Saha, S., Flowers, E., Ang, C.-S., Casson, A. J., Condell , J., Matcham, F., Robinson, T. & Rooksby, J., 24 Apr 2025, In: Journal of Medical Internet Research. 27, e66034.Research output: Contribution to journal › Article › peer-review
Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia
Kelu, J. J. & Hughes, S. M., 13 May 2025, In: Proceedings of the National Academy of Sciences USA. 122, 19, e2422446122.Research output: Contribution to journal › Article › peer-review
Theory of Mind Mediates the Association Between Autistic Traits and Social Isolation in Middle-Aged and Older Adults
Lo, G. H. M., Dale, C., Happe, F. & Stewart, G., 4 Apr 2025, In: Autism research. 18, 6, p. 1234-1244 11 p.Research output: Contribution to journal › Article › peer-review
The quality of life of older carers and the people they support: An international scoping review
Zhang, W., Rand, S., Milne, A., Collins, G. & Silarova, B., Dec 2022, In: Health and Social Care in the Community. 30, 6, p. e3342-e3353Research output: Contribution to journal › Article › peer-review
Awards
Selected Ageing Research Funding at King's:
- HealthTech Research Centre for Dementia and Brain Health (National Institute for Health and Care Research)
- Diverging dynamic resilience: Using twins to identify frailty drivers independent of shared genetics in the context of the COVID-19 pandemic (Wellcome Leap)
- Midlife Aging in the Dunedin Study Phase 52 (Medical Research Council)
- PREDICTOM: Prediction of neurodegenerative disease using an AI driven screening platform (Technology Strategy Board)
- Comparing the phenotypes and trajectories of human ageing associated with exercise or inactivity: with a particular focus on the biology of skeletal muscle and the immune system (Nadace The JetBrains Foundation)
- Mechanisms of vascular smooth muscle cell ageing and calcification –developing a timeline for novel therapeutic interventions (British Heart Foundation)
- TwinsUK Imaging: A Resource for Ageing Research (Chronic Disease Research Foundation)
- Mathematical modelling of muscle stem cell behaviour in ageing (Leverhulme Trust)
- The Sciences of ageing and the culture of youth: 1880 to the present day (MRC Medical Research Council)
- Microvascular dysfunction and inflammation in the brain ageing (Stavanger University Hospital),
- Decoding the role of follicle stimulating hormone in ovarian ageing (BBSRC Biotechnology and Biological Sciences Research Council)
- Modelling brain ageing using neuroimaging to improve brain health in older adults (MRC Medical Research Council)
- The influence of TRPA1 signalling on the response to cold exposure as ageing occurs (BBSRC Biotechnology and Biological Sciences Research Council),
- Function of post-translational modifications of protein backbones in signalling and molecular ageing (Wellcome Trust)
- Promoting mental wellbeing in the ageing urban population: determinants, policies and interventions in European cities - MINDMAP (EC European Commission)
- Epigenetic responses to social and environmental cues in early life and over the life course: impact on healthy ageing in UK population-based cohorts (ESRC Economic and Social Research Council)
- Lifecourse biological pathways underlying social differences in healthy ageing (LIFEPATH) (EC European Commission)
- The underlying mechanisms of ageing in the inner ear (BBSRC Biotechnology and Biological Sciences Research Council)
- Colorado adoption/twin Study of lifespan behavioural development and cognitive ageing (CATSLife) (NIH National Institutes of Health)
- ATHLOS - ageing trajectories of health: longitudinal opportunities and synergies (EC European Commission)
- Multi-scale analysis of B cell responses in ageing (MRC Medical Research Council)
- Mechanisms of vascular smooth muscle cell ageing and calcification (BHF British Heart Foundation)
- The role of multi-innervated dendritic spines in memory formation in ageing (BBSRC Biotechnology and Biological Sciences Research Council)
- Exploring frailty, mental health and related outcomes: a multi-cultural population based approach to ageing (MRC Medical Research Council)
- Midlife pace of ageing in the Dunedin study (MRC Medical Research Council)
Activities
Ageing Research at King's Events
ARK hosts events on ageing and healthy longevity across a broad spectrum of themes with a life course approach with UK and international speakers from academia, industry, foundations and governments. Talks have covered themes including entrepreneurship, commercialization, digital innovation, social impact and economics of ageing and government policy, biomarkers of ageing, age-related conditions, physical activity, nutrition, basic and clinical ageing research.
Centre for Integrative Chinese Medicine
ARK has partnered with the Centre for Integrative Chinese Medicine, a multidisciplinary research initiative across KCL and King's Health Partners which aims to integrate traditional Chinese medicine (TCM) with conventional clinical practice.
Early Adopters of Our Future Health
ARK Director Richard Siow and Advisory Board member Cathryn Lewis are selected as Research Ambassadors for Our Future Health's Early Adopters programme. The initiative aims to gather data from up to 5 million adults in the UK to discover new ways to prevent, detect and treat diseases and help everyone live longer and healthier lives.
ARK Longevity Week 2024
The ARK Longevity Week event in November 2024, in partnership with European Society of Preventive Medicine and Longevity Science Foundation, focused on innovations in prevention across the lifespan. The Keynote was given by Nathan Price, Buck Institute, California with industry speakers from Dexcom, Aktivo Labs and Muhdo Health
ARK partners the EMPOWER Dementia Network
The EMPOWER network will assess the growing need for high-quality dementia care, funded by the Alzheimer's Society, Economic and Social Research Council and National Institute for Health and Care Research. Led by Prof Catherine Evans, Faculty of Nursing, Midwifery & Palliative Care, the project will also span the Institute of Psychiatry, Psychology and Neuroscience and Faculty of Social Science & Public Policy.
International Symposium on Metallomics
We are pleased to partner with the 9th International Symposium on Metallomics (17-21 June 2024) hosted at King's College London. The field of metals in ageing research bridges numerous disciplines and is crucial for developing solutions to human and environmental issues in ageing societies. ARK will convene a panel discussion with leading experts on metals in healthy ageing and longevity.
Centre for Ageing Resilience in a Changing Environment (CARICE)
ARK is pleased to incorporate CARICE, a new centre of excellence within the Faculty of Life Sciences & Medicine. The centre mission is to centralise and focus ageing research across the faculty to reduce the negative collective impact of the major colliding global challenges of climate change and population ageing.
NIHR centre to aid diagnosis and treatment of dementia
The new HealthTech Research Centre for Brain Health, established through £2.9m funding from National Institute for Health and Care Research, aims to accelerate the advancement of cutting-edge technology to better understand brain health and ageing and help people live healthier lives for longer. The Centre will be associated with ARK and led by Dag Aarsland, Head, Centre for Healthy Brain Ageing and ARK Co-Director.
PREDICTOM - Early Dementia Detection
The new PREDICTOM project, led by Dag Aarsland, at KCL and Stavanger University Hospital, was funded to develop AI platforms capable of identifying people at risk of dementia before the first symptoms appear. ARK will be associated with the consortium of 30 partners from more than 15 countries include universities, businesses, institutes and hospitals and is backed by €21m funding from the EU Innovative Health Initiative and industry.
ARK Longevity Week 2023 Event
ARK hosted "Sustainable Longevity: Harnessing Consumer HealthTech and FinTech" in partnership with European Society of Preventive Medicine (ESPM), Longevity Science Foundation and Longevity Forum, as part of Longevity Week in November 2023. The event included our ARK Entrepreneur in Residence and speakers from Mastercard UK, Nestle Health Sciences, Muhdo Health, Huumans, William Harvey Heart Centre at Queen Mary and ESPM.
European Society of Preventive Medicine partnership
The ESPM - ARK partnership will facilitate the intersection of basic research, clinical medicine, and community physical, mental and financial health with a focus on the prevention and prediction of chronic and age-related diseases across the lifespan. Prof Pekka Puska, ESPM President spoke at the launch event on 27 September 2023 which included a keynote by Raghib Ali OBE, CEO of Our Future Health.
MRC Award to Extend Dunedin Study
An ARK Team led by Terrie Moffitt with Avshalom Caspi, Dag Aarsland and Richard Siow have been awarded £1.4m by the MRC to quantify the pace of ageing for the Dunedin Study in 8 domains: biological aging, functional aging, facial aging, social aging, sexual aging, inflammatory aging, microvascular aging, and cognitive aging.
Physiological Society AI for Health Report
ARK Director Richard Siow Chaired the Steering Committee of a new Physiological Society report which highlights physiology’s role in unlocking the potential of artificial intelligence for health. The report was launched at the House of Lords on 27 June 2023 hosted by Viscount Stansgate and Stephen Metcalf MP. Dr Siow and ARK Entrepreneur in Residence Svitlana Surodina, were invited speakers.
Longevity Science Foundation Partnership
The ARK-LSF partnership launch was hosted by the School of Academic Psychiatry and included talks by Lisa Ireland (CEO, LSF), Guy Goodwin (CMO, COMPASS Pathways), Allan Young (Vice-Dean, Academic Psychiatry) and Dag Aarsland (Head, Old Age Psychiatry). The partnership will advance research and education in healthy ageing, longevity and psychological well-being.
Oxford Ageing Research Hub Partnership
The University of Oxford Ageing Research Collaborative Hub (ARCH) partnership aims to develop research collaborations, public engagement events, education initiatives and academic exchanges with ARK. ARCH includes the Institute of Population Ageing and Oxford Ageing Network (OxAgeN).
UK National Innovation Centre for Ageing (NICA) Partnership
ARK has partnered with NICA at Newcastle University to establish joint education, research and innovation activities. This will be initiated through a King's based VOICE chapter, symposia and researcher exchanges. Together with Collider Health, NICA launched the "Quantum Healthy Longevity" initiative at a Longevity Week event hosted by ARK with Keynote by Lord James Bethell.
ARK Longevity Week 2022 Event
The ARK hybrid event "Data-Driven Longevity: Digital technologies for collaborative innovation and healthy longevity" on 18 November included a keynote lecture by Sarah Harper, Director, Institute of Ageing, University of Oxford and talks by ARK academic and industry partners. The program and recordings are available below.
SleepCity at King's partners with ARK
The Sleep and Brain Plasticity Centre (SleepCity) at King's is a collaboration between Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience and Sleep Disorders Centre at Guy’s Hospital. ARK related projects will explore the role of sleep on cognitive ageing, neurodegeneration and interventions for healthy longevity.
ARK Partners with Centre for Mental Health Research & Innovation
King's new Centre for Mental Health Research & Innovation led by Allan Young, Vice Dean, Institute of Psychiatry, Psychology & Neuroscience, will be developing a partnership with ARK. In collaboration with the South London & Maudsley NHS Foundation Trust and COMPASS Pathways, research in the Centre will include psychedelics, cannabinoids and new models of care for mental and cognitive wellness in ageing societies.
ARK partners with RADAR-AD
ARK is pleased to partner with Remote Assessment of Disease and Relapse - Alzheimer’s Disease, a platform led by Prof Dag Aarsland, Head of Old Age Psychiatry at King's, to transform patient care through remote assessment using mobile technologies to identify digital biomarkers for predicting deterioration. This consortium of academic and industry members is funded by the European Commission Innovative Medicines Initiative.
Longevity Week 2021 - Innovations in Consumer Longevity Data
ARK hosted "Innovations in Consumer Longevity Data: A Global Perspective" on 19 November, highlighting the UN Decade of Healthy Ageing (keynote by Ritu Sadana, WHO) and the Open Life Data Framework (APPG for Longevity). Organisations represented included University of Zurich, National University of Singapore, AXA Health, Legal & General, Nestle Health Sciences Institute, Deep Longevity, Insilico Medicine and Longevity Science Foundation. The event was opened by Prof Reza Razavi, King's Vice President (Research).
Zurich Healthy Longevity Innovation Cluster - ARK Strategic Partnership
ARK has established a strategic partnership with the University of Zurich (UZH) Innovation Hub to facilitate academic exchange and industry engagement between King's and UZH through their Healthy Longevity Innovation Cluster, Dynamics of Healthy Ageing Research Priority Program and WHO Healthy Ageing Centre. The UK Embassy in Bern celebrated the partnership in late September 2021 by hosting an event including UZH Vice President (Research), King's Global Envoy (Health) and Head of WHO Decade of Healthy Ageing.
Biological ageing R&D with Muhdo Health
ARK has established a collaboration in healthy ageing and informatics with Muhdo Health a consumer epigenetics platform. Together with ARK academics and industry partners, Muhdo aims to develop the next generation of technologies to better assess biological age by integrating biomarkers with lifestyle and environmental data through advanced data analytics.
Nobel Laureate Prof Sir Peter Ratcliffe speaks at Metallomics and Oxygen Symposium
The London Metallomics Facility and ARK jointly hosted a symposium on 5 May 2021 featuring a keynote lecture by Prof Sir Peter Ratcliffe FRS, Director of Clinical Research at the Francis Crick Institute and Director of the Target Discovery Institute at Oxford University. He won the Nobel prize in Physiology or Medicine in 2019 jointly with William Kaelin (Harvard University) and Gregg Semenza (Johns Hopkins University), for their 'discoveries of how cells sense and adapt to oxygen availability'. Prof Reza Razavi, King's VP (Research) gave the vote of thanks.
International Longevity Policy & Governance Summit - Longevity Week 2020
ARK hosted the Second Longevity Policy and Governance Summit as part of Longevity Week 2020, with the theme to address the challenges of ageing societies globally we can strive to ensure healthier, longer lives can be achieved by all. The keynote lecture was given by Prof Sir Robert Lechler, King's Provost and Senior VP (Health).
All Party Parliamentary Group for Longevity: National Strategy Launch, February 2020
As a founding member of the APPG for Longevity, ARK hosted the launch of the "Health of the Nation" report with keynote lecture by the Health Secretary Rt Hon. Matt Hancock MP and talks by Damian Green MP, Lord Geoffrey Filkin, Jon Ashworth MP, Lord Kerslake, Lord O’Shaughnessy, Prof Sir Robert Lechler, KCL Provost and Senior VP (Health) and other distinguished speakers.
AI for Longevity Summit - Longevity Week 2019
ARK hosted the first AI for Longevity Summit at King's on 12 November 2019. This event included participation by financial institutions, insurance and technology companies and policy makers from across the public and private sectors. This summit led to the establishment of the Longevity AI Consortium and highlighted the importance of AI for R&D in healthy ageing. Prof Reza Razavi, King's VP (Research) and Director of the AI Centre for Value Based Healthcare participated in the summit.
International Longevity Policy & Governance Summit - Longevity Week 2019
ARK hosted the International Longevity Policy and Governance as part of Longevity Week 2019, bringing together policy experts, representatives of government bodies, healthcare and finance ministries, executives of healthcare and financial corporations to discuss initiatives for enhancing longevity. The event highlighted the international response to harnessing the opportunities of an ageing demographic, with lessons learned and shared across countries from a policy perspective – taking societal, cross sector and government approaches.
Insilico Medicine and ARK collaborate in AI for Healthy Longevity
Insilico Medicine, a biotech company developing the end-to-end drug discovery pipeline utilizing next-generation artificial intelligence, announces its partnership with ARK - dedicated to enhancing multidisciplinary research collaborations across King’s and King’s Health Partners to better understand the mechanisms of ageing and improving health-span.
Funding for ARK research on physical activity for healthy longevity
ARK researchers in the Centre for Human & Applied Physiological Sciences at KCL have been awarded £1.5m by Nadace The JetBrains Foundation to explore the effects of inactivity on physiological function. In collaboration with University of Birmingham, researchers examined the health of older adults who regularly exercised and the impact this had on ageing.
Vascular Healthy Ageing Research at King's BHF Centre of Excellence funded by BIRAX
The King's School of Cardiovascular Medicine and Sciences (Prof Manuel Mayr) together with the Hebrew University of Jerusalem (Prof Eli Keshet) were awarded funding in 2019 by the British Council BIRAX programme for a novel approach to combat age-associated deterioration of vascular function. Given the multiple roles of the vascular system, they propose that certain interventions can be geroprotective.
Launch of BIRAX Ageing Programme
The British Council UK-Israel Research and Academic Exchange Programme in Healthy Ageing was launched at the BIRAX conference hosted by ARK in September 2018. The conference was opened by David Quarrey, British Ambassador to Israel, Prof Lord Robert Winston & Prof Ruth Arnon, Co-Chairs, UK-Israel Science Council, Christian Duncumb, Director, British Council Israel and Prof Reza Razavi, King's Vice President (Research).
Keynote Event - Prof Sir Edward Byrne and Prof Sir Salvador Moncada
On 31 May 2018 ARK hosted a keynote event with talks by Prof Sir Edward Byrne AC, President & Principal of King’s and Prof Sir Salvador Moncada FRS, FMedSci, School of Medical Sciences, University of Manchester. Prof Byrne spoke about mitochondria in ageing and Prof Moncada highlighted his distinguished research on nitric oxide in physiology and pathophysiology. Prof Sir Robert Lechler, Provost & Senior Vice President (Health) and Executive Director, King's Health Partners gave the vote of thanks.
News
King's academics present their research at healthy ageing events in China
Researchers from King’s College London recently attended two events in China that shared insights into international strategies to promote healthy ageing and...
Study explores how a supplement containing components of the Mediterranean diet can affect epigenetics associated with healthy ageing
Participants taking the supplement showed changes in blood biomarkers and the epigenetic regulation of DNA, which are associated with healthy ageing.
New HealthTech Research Centre in Brain Health celebrates launch
Over 100 guests celebrated the launch of the new centre at the London Institute for Healthcare Engineering (LIHE) on 11 June 2024.
King's College London part of €21 million PREDICTOM study to pioneer early detection of Alzheimer's Disease
A new AI-screening platform to be developed to identify individuals at risk of developing dementia, even before symptoms manifest.
£2.9m for new centre to aid diagnosis and treatment of dementia
New National Institute for Health and Care Research (NIHR) HealthTech Research Centre is designed to accelerate the advancement of cutting-edge technology to...
Events
NIHR HealthTech Research Centre in Brain Health - Industry Panel Meeting 3
HealthTech Research Centre Industry Panel
Please note: this event has passed.
Ethical AI: Safer and Faster Innovation in Healthy Brain Ageing
Ethical AI: a safer, faster innovation in Healthy Ageing & Brain Health
Please note: this event has passed.
New Ways to Support Older People: The Role of Technology in Social Care
Join us for the 2025 Institute of Gerontology Lecture hosted in collaboration with the Gateway to Global Aging Data at King’s College London
Please note: this event has passed.
transCampus International Roadshow - Kuwait
Transcampus - ARK event in Kuwait
Please note: this event has passed.
ARK Global
ARK Partners in Europe
- UK National Innovation Centre for Ageing
- University of Exeter, UK
- MIA - University of Coimbra, Portugal
- Charité Universitätsmedizin Berlin, Germany
- German Institute of Human Nutrition
- Freie Universität Berlin, Germany
- Karolinska Institutet, Sweden
- Norwegian Centre on Healthy Ageing
- Stavanger University Hospital, Norway
- TU Dresden (TransCampus), Germany
- University of Zurich, Switzerland
ARK partners in Asia & Australasia
- Monash University, Australia
- Agency for Science, Technology and Research, Singapore
- National University of Singapore
- Keio University, Japan
- Peking University Health Science Center, China
- Southern University of Science & Technology, China
- Southwest Jiaotong University, China
- Chinese University of Hong Kong
- Hong Kong Quantum AI Lab, InnoHK R&D Centre
- Technion Institute of Technology, Israel
People
Director, Centre for Healthy Brain Ageing
ARK Innovation Advisor
TransCampus Dean
Senior Lecturer (Associate Professor) in Strategic Marketing
Professor of Population and Digital Health Sciences
ARK Executive Advisor
Themes
Ageing, Resilience and Society
Established research programme with strong emphasis on multidisciplinary and multiagency work, research on Ageing & Society at King’s is led by the Institute of Gerontology and Centre for Global Ageing. Together with the new Centre for Ageing Resilience in a Changing Environment, research focuses on broad topics ranging from the social and economic factors associated with the ageing through to the psychological, biomedical and global aspects of ageing demographics.
Clinical Research and Practice
Through world leading expertise across King's Health Partners and the Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, ARK undertakes clinical research in the treatment and care of individuals with age-related diseases, including cancer, rheumatoid arthritis, cardiovascular disease and stroke. Aiming to achieve the best possible quality of life for patients and their families, and includes geriatric medicine, control of pain as well as attention to psychological, social considerations in the elderly.
Mechanisms of Biological Ageing
Multidisciplinary basic and clinical research environment to elucidate the mechanisms of age-related conditions such as dementia, cardiovascular disease, inflammation and frailty - from cell and molecular biology to physiological, epigenetics, nutrition and microbiome studies in man - this synergistic approach facilitates development of interventions for multi-morbidity in ageing societies and enhanced healthy longevity.
Care of the Elderly
Research across several departments at King's focuses on social and clinical research on living well with frailty, dementia communication and improving care experiences in older people. Discovery and innovation to create knowledge and impact nursing, midwifery, and healthcare policy and practice, as well as how we educate those providing care of the elderly. The Cicely Saunders Institute is the first purpose built institute for research into palliative care, policy and rehabilitation.
Healthy Brain Ageing
The Institute of Psychiatry, Psychology and Neuroscience focuses on the ageing brain and associated mental health. Research includes the molecular mechanisms and discovery of novel therapies for neurodegeneration, maintenance of mental wellness, Parkinson’s and Alzheimer’s diseases, depression, psychoses, sleep, neuroimaging and digital health informatics. Centres of excellence include the UK Dementia Research Institute and the Wolfson Centre for Age Related Diseases. Commercial collaborations are facilitated through the Centre for Innovative Therapeutics.
Oral Health
The Faculty of Dentistry, Oral and Craniofacial Sciences at King's has a number of ARK affiliated groups has a broad portfolio oral health research directed towards ageing populations, from basic science, through to transnational research, public health and social & behavioural sciences. Focusing on mouth as an ecosystem, the role of saliva, taste sensation and oral microbiome known to be affected by ageing.
AI in Ageing Research and Healthy Longevity
Ues of AI technologies within longevity and ageing research is increasing in both academia and industry. To utilise the latest AI advances and accelerate innovation and technology transfer, ARK has partnered with the King's AI Centre for Value Based Healthcare and our industry partners Insilico Medicine and Deep Longevity to establish a Longevity AI Consortium. Machine learning is used to develop longevity and ageing predictors offer new possibilities for diverse data types. This will enable a holistic view aiming to identify novel longevity and healthy ageing biomarkers, accelerate diagnosis of age-related diseases, refine demographic and clinical methods, develop personalised interventions to promote lifestyles for healthy longevity.
Economics of Healthy Ageing
Together with King's Business School, ARK researchers are developing an international network focusing on financial longevity and the economic burden of a global changing population demographics through innovation and opportunities for enhancing productivity of the ageing workforce. We are working with global corporate partners in the pharma, food, insurance and consumer goods sectors to address these issues and to develop commercialization opportunities.
Industry Engagement
The Unilever Bioscience Innovation Hub at King's established in 2020 provides a centre of expertise building on the strengths of the Unilever Framework Agreement. The Hub has bought Unilever researchers and King’s academics together to focus on research in personal care, human biology, microbiology and healthy ageing. Over the last 10 years the Unilever partnership has leveraged over £5m in funding for collaborative projects across King's.
Entrepreneurship in Healthy Longevity
ARK is uniquely placed to have an Entrepreneur in Residence based in the Department of Informatics at King's focusing on Human Centred Computing, Data Sciences and Digital Health. The King's Entrepreneurship Institute also offers students and researchers support in innovation and commercialization opportunities to tackle novel approaches to enhance healthy longevity.
Integrative Medicine for Healthy Ageing
The King's Centre for Integrative Chinese Medicine is a multidisciplinary research initiative across several faculties at KCL and King's Health Partners which aims to integrate traditional Chinese medicine (TCM) and alternative therapies from other regions with conventional clinical practice.
Longevity Policy and Governance
ARK is a founding member of the All Party Parliamentary Group (APPG) for Longevity and hosted the launch of "Health of the Nation: National Strategy for Healthier Longer Lives" report in February 2020. ARK continues to support the APPG through the Open Life Data Framework and Business for Health initiatives. The Policy Institute at King's provides evidence and expertise to inform global policy and practice in healthy ageing.
Publications
Selected ageing research publications from across King's:
Lifespan investigation of brain volumetric changes associated with substance use disorders
Lin, X., Shi, R., Xiang, S., Alnæs, D., Chen, D., Zheng, C., Banaschewski, T., Barker, G., Bokde, A., Desrivières, S., Flor, H., Garavan, H., Gowland, P., Grigis, A., Heinz, A., Martinot, J.-L., Martinot, M.-L., Artiges, E., Nees, F. & Orfanos, D. P. & 12 others, Poustka, L., Smolka, M., Hohmann, S., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Sahakian, B., Westlye, L. T., Robbins, T., Jia, T. & Feng, J., 26 Jun 2025, In: Nature Mental Health .Research output: Contribution to journal › Article
Transforming Geriatric Care: The Role of Remote Sensing Technologies in Nursing for Older Adults
Horta Reis Da Silva, T., 16 Jul 2025, Remote Sensing for Environmental Monitoring. Saritha, V., Pande, C. B., Singh, R. & Shahid, M. (eds.). SPRINGERNATURE, p. 95-119 25 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Exploring the use of musical activities implemented in home-based dementia care as part of the HOMESIDE study
Crabtree, S., Baker, F. A., Bukowska, A. A., Hsu, M.-H., Kvamme, T., McMahon, K., Odell-Miller, H., Sousa, T., Stensæth, K., Wosch, T. & Tamplin, J., 2 Jul 2025, In: Arts and Health.Research output: Contribution to journal › Article › peer-review
Human development, inequality, and their associations with brain structure across 29 countries
Medel, V., Alliende, L. M., Bethlehem, R. A. I., Seidlitz, J., Ringlein, G., Arango, C., Arnatkeviciute, A., Asmal, L., Bellgrove, M. A., Benegal, V., Bernardo, M., Billeke, P., Jorge, B.-B., Bressan, R., Busatto Filho, G., Castro, M., Chaim-Avancini, T. M., Costanzi, M., Czepielewski, L. S. & Dazzan, P., 16 Jul 2025, (E-pub ahead of print) In: European Psychiatry.Research output: Contribution to journal › Article › peer-review
Land Restoration Amid Male Outmigration: The Cases of Burkina Faso and Kenya
Langill, J. C., Crossland, M., Elias, M., Vinceti, B., Paez Valencia, A. M., Traoré, A. & Traoré, D., 1 Dec 2023, In: Ecological Restoration. 41, 4, p. 220-235Research output: Contribution to journal › Article › peer-review
Gendered effects of migration on social organization and smallholder production in Oubritenga Province, Burkina Faso
Langill, J. C., Elias, M., Vinceti, B., Traoré, A. & Traoré, D., 4 Feb 2023, In: Journal of Rural Studies. 98, p. 19-33Research output: Contribution to journal › Article › peer-review
Neoadjuvant chemotherapy in relation to long-term mortality in individuals cured of gastric adenocarcinoma
Leijonmarck, W., Mattsson, F. & Lagergren, J., 31 Jan 2025, In: Gastric Cancer. 28, 1, p. 96-101 6 p.Research output: Contribution to journal › Article › peer-review
Prenatal and progressive coenzyme Q10 administration to mitigate muscle dysfunction in mitochondrial disease
Hernández-Camacho, J. D., Vicente-García, C., Ardila-García, L., Padilla-Campos, A., López-Lluch, G., Santos-Ocaña, C., Zammit, P. S., Carvajal, J. J., Navas, P. & Fernández-Ayala, D. J. M., Dec 2024, In: Journal of cachexia, sarcopenia and muscle. 15, 6, p. 2402-2416 15 p.Research output: Contribution to journal › Article › peer-review
Prediction model for postoperative pulmonary complications after thoracoscopic surgery with machine learning algorithms and SHapley Additive exPlanations
Wang, S., Lin, Y., Shi, H., Liang, P., Luo, Z., Kong, J., Huang, J., Cheng, M., Zhang, B., Wang, Y., Kan, H., Liang, L. & Xie, W., 30 Jun 2025, In: Journal of Thoracic Disease. 17, 6, p. 3603-3618 16 p.Research output: Contribution to journal › Article › peer-review
Tooth loss, diet quality, and cognitive decline: A 15-year longitudinal study
Winning, L., Logan, D., McEvoy, C. T., Farsi, D., McKay, G. J., Patterson, C. C., Passmore, P., Holmes, C., Linden, G. J. & McGuinness, B., 27 Jun 2025, (E-pub ahead of print) In: The journal of nutrition, health & aging. 29, 9, 100620.Research output: Contribution to journal › Article › peer-review
Impact of age on the homing potential of 89 Zr-radiolabelled CD8+ T cells
Bystrom, J., Pereira Da Costa, M., Minino, A., Qureshi, A., Keeling, G. P., Pham, T. T., Sunassee, K., Carroll, E., Garrod-Ketchley, C., Schroth, J., Tsang, V., T. M. de Rosales, R., Terry, S. Y. A. & Henson, S. M., 3 Jul 2025, (E-pub ahead of print) In: Scientific Reports. 15, 1, 23801 .Research output: Contribution to journal › Article › peer-review
Assessment of frailty in patients with heart failure: A new Heart Failure Frailty Score developed by Delphi consensus
Vitale, C., Berthelot, E., Coats, A. J. S., Loreena, H., Albert, N. M., Tkaczyszyn, M., Adamopoulos, S., Anderson, L., Anker, M. S., Anker, S. D., Bell, D., Ben-Gal, T., Bistola, V., Bozkurt, B., Brooks, P., Camafort, M., Carrero, J. J., Chioncel, O., Choi, D.-J. & Chung, W.-J. & 41 others, Doehner, W., Fernández-Bergés, D., Ferrari, R., Fiuzat, M., Gomez-Mesa, J. E., Gustafsson, F., Jankowska, E., Kang, S.-M., Kinugawa, K., Khunti, K., Hobbs, F. D. R., Lee, C., Lopatin, Y., Maddocks, M., Maltese, G., Marques-Sule, E., Matsue, Y., Miró, Ò., Moura, B., Piepoli, M., Ponikowski, P., Pulignano, G., Rakisheva, A., Ray, R., Sciacqua, A., Seferovic, P., Sentandreu-Mañó, T., Sze, S., Sinclair, A., Strömberg, A., Theou, O., Tsutsui, H., Uchmanowicz, I., Vidan, M. T., Volterrani, M., von Haehling, S., Yoo, B., Zhang, J., Zhang, Y., Metra, M. & Rosano, G. M. C., Jun 2025, In: ESC Heart Failure. 12, 3, p. 1818-1831 14 p.Research output: Contribution to journal › Article › peer-review
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
Saeedi Saravi, S. S., Pugin, B., Constancias, F., Shabanian, K., Spalinger, M., Thomas, A., Le Gludic, S., Shabanian, T., Karsai, G., Colucci, M., Menni, C., Attaye, I., Zhang, X., Allemann, M. S., Lee, P., Visconti, A., Falchi, M., Alimonti, A., Ruschitzka, F. & Paneni, F. & 1 others, Beer, J. H., Jun 2025, In: Nature Aging. 5, 6, p. 1025-1045 21 p.Research output: Contribution to journal › Article › peer-review
Risk factors for depressed mood amongst a community dwelling older age population in England: Cross-sectional survey data from the PRO-AGE study
Biddulph, J. P., Iliffe, S., Kharicha, K., Harari, D., Swift, C., Gillmann, G. & Stuck, A. E., 23 Jan 2014, In: BMC Geriatrics . 14, 1, 5.Research output: Contribution to journal › Article › peer-review
Associations between different measures of SARS-CoV-2 infection status and subsequent economic inactivity: A pooled analysis of five longitudinal surveys linked to healthcare records
Shaw, R. J., Hamilton, O. K. L., Rhead, R., Silverwood, R. J., Wels, J., Zhu, J., Di Gessa, G., Bowyer, R. C. E., Moltrecht, B., Green, M. J., Demou, E., Pattaro, S., Zaninotto, P., Boyd, A., Greaves, F., Chaturvedi, N., Ploubidis, G. B. & Katikireddi, S. V., 9 Apr 2025, (E-pub ahead of print) In: PLoS ONE. 20, 4 April, e0321201.Research output: Contribution to journal › Article › peer-review
Meaningful volunteer involvement in adult social care (ASC): Perspectives from diverse ASC providers, key informants, and evaluation of the NHS and Care Volunteer Responders scheme
Kharicha, K., Leverton, M., Owen, J., Norrie, C., Burch, T. & Hickman, B., 26 Jun 2025, London: NIHR Policy Research Unit in Health and Social Care Workforce, The Policy Institute, King's College London. 57 p.Research output: Book/Report › Commissioned report › peer-review
Parental death in childhood and stock market participation: Cross-cultural insights
Wang, Y., Driouchi, T. & Nguyen, D. D., Aug 2025, In: Journal of Economic Behavior and Organization. 236, 107078.Research output: Contribution to journal › Article › peer-review
Lifespan investigation of brain volumetric changes associated with substance use disorders
IMAGEN Consortium, 28 May 2025, In: MedRxiv.Research output: Contribution to journal › Article
Single-Subject Network Analysis of FDOPA PET in Parkinson's Disease and Psychosis Spectrum
FDOPA PET Imaging Working Group Consortium, 12 Jun 2025, (E-pub ahead of print) In: Human Brain Mapping. 46, 8, p. e70253 e70253.Research output: Contribution to journal › Article › peer-review
Does a palliative medicine service reduce hospital length of stay and costs in adults with a life-limiting illness?-a difference-in-differences evaluation of service expansion in Ireland
Matthews, S., Hurley, E., Johnston, B. M., Kane, P., Ryan, K., Tiernan, E., Normand, C. & May, P., 22 Jul 2024, In: Annals of Palliative Medicine. 13, 4, p. 766-777 12 p.Research output: Contribution to journal › Article › peer-review
Cohort profile. characterisation, determinants, mechanisms and consequences of the long-term effects of COVID-19 - providing the evidence base for health care services (CONVALESCENCE) in the UK
Jamieson, A., Saikhan, L. A., Raman, B., Alghamdi, L., Conde, P., Dobson, R., Fernández-Sanlés, A., Folarin, A., Goudswaard, L. J., Hamill Howes, L., Jones, S., Neubauer, S., Orini, M., Pierce, I., Ranjan, Y., Rapala, A., Smith, S. M., Sudre, C., Thompson, E. J. & Wild, J. & 6 others, Williams, D., Wong, A., Steves, C. J., Timpson, N., Chaturvedi, N. & Hughes, A., 5 Jun 2025, In: BMJ Open. 15, 6, e094760.Research output: Contribution to journal › Article › peer-review
An Agenda for the Medical Humanities and Ageing
Zimmermann, M., 2025, (Accepted/In press) In: History of the Human Sciences.Research output: Contribution to journal › Article › peer-review
Developing cardiac digital twin populations powered by machine learning provides electrophysiological insights in conduction and repolarization
Qian, S., Ugurlu, D., Fairweather, E., Toso, L. D., Deng, Y., Strocchi, M., Cicci, L., Jones, R. E., Zaidi, H., Prasad, S., Halliday, B. P., Hammersley, D., Liu, X., Plank, G., Vigmond, E., Razavi, R., Young, A., Lamata, P., Bishop, M. & Niederer, S., 16 May 2025, (E-pub ahead of print) In: Nature Cardiovascular Research. 4, 5, p. 624-636 13 p., 11437.Research output: Contribution to journal › Article › peer-review
The expanding clinical and genetic spectrum of DYNC1H1-related disorders
Möller, B., Becker, L. L., Saffari, A., Afenjar, A., Coci, E. G., Williamson, R., Ward-Melver, C., Gibaud, M., Sedláčková, L., Laššuthová, P., Libá, Z., Vlčková, M., William, N., Klee, E. W., Gavrilova, R. H., Lévy, J., Capri, Y., Scavina, M., Körner, R. W. & Valivullah, Z. & 36 others, Weiß, C., Möller, G. M., Frazier, Z., Roberts, A., Gener, B., Scala, M., Striano, P., Zara, F., Thiel, M., Sinnema, M., Kamsteeg, E. J., Donkervoort, S., Duboc, V., Zaafrane-Khachnaoui, K., Elkhateeb, N., Selim, L., Margot, H., Marin, V., Beneteau, C., Isidor, B., Cogne, B., Keren, B., Küsters, B., Beggs, A. H., Sveden, A., Chopra, M., Genetti, C. A., Nicolai, J., Dötsch, J., Koy, A., Bönnemann, C. G., von der Hagen, M., von Kleist-Retzow, J. C., Voermans, N. C., Jungbluth, H. & Dafsari, H. S., 1 Feb 2025, In: Brain. 148, 2, p. 597-612 16 p.Research output: Contribution to journal › Article › peer-review
DunedinPACNI estimates the longitudinal pace of aging from a single brain image to track health and disease
Whitman, E. T., L Elliott, M., Knodt, A. R., Abraham, W. C., Anderson, T. J., Cutfield, N. J., Hogan, S., Ireland, D., Melzer, T. R., Ramrakha, S., Sugden, K., Theodore, R., Williams, B. S., Caspi, A., Moffitt, T. & Hariri, A. R., 1 Jul 2025, (E-pub ahead of print) In: Nature Aging. 582.Research output: Contribution to journal › Article › peer-review
Type-Specific Single-Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes
Troakes, C., Bodi, I., Pienaar, I., Stephenson, E., Bailey, L. J., Gentleman, S., Tuppen, H., Morris, C. M., Carr, T. M., Guthrie, S. & Elson, J. L., 6 Jun 2025, In: Ageing Cell. e70125.Research output: Contribution to journal › Article › peer-review
The impact of perceptual complexity on road crossing decisions in younger and older adults
Nicholls, V. I., Wiener, J., Meso, A. I. & Miellet, S., 4 Jan 2024, (E-pub ahead of print) In: Scientific Reports. 14, 1, 479.Research output: Contribution to journal › Article › peer-review
Conducting adult social care research in the United Kingdom – impacts of challenges to study processes on study feasibility.
Fitzpatrick, J. M., Worsley, P. R., Chatterton, C., Fader, M., Graham, T., Norton, C., Woodward, S. & Harris, R., 14 May 2025, (Accepted/In press) In: Age and Ageing.Research output: Contribution to journal › Article › peer-review
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Jacques, M., Landen, S., Sharples, A. P., Garnham, A., Schittenhelm, R., Steele, J., Heikkinen, A., Sillanpää, E., Ollikainen, M., Broatch, J., Zarekookandeh, N., Hanson, O., Ekström, O., Asplund, O., Lamon, S., Alexander, S. E., Smith, C., Bauer, C., Woessner, M. N. & Levinger, I. & 16 others, Teschendorff, A. E., Gillberg, L., Blom, I., Helge, J. W., Harvey, N. R., Haupt, L. M., Griffiths, L. R., Deshmukh, A. S., Pietiläinen, K. H., Piirilä, P., Seaborne, R. A. E., Klevjer, M., Bye, A., Wisløff, U., Jones-Freeman, B. & Eynon, N., 24 Jun 2025, In: Cell Reports. 44, 6, 115750.Research output: Contribution to journal › Article › peer-review
How many people will live and die with serious illness in Ireland to 2040? Estimated needs and costs using microsimulation
May, P., Normand, C., Smith, S., Moriarty, F., Ward, M., Ryan, K., Johnston, B. M., Romero-Ortuno, R., Kenny, R. A., Sean Morrison, R. & Tysinger, B., Oct 2024, In: Journal of the Economics of Ageing. 29, 100528.Research output: Contribution to journal › Article › peer-review
Projecting future health and service use among older people in Ireland: an overview of a dynamic microsimulation model in The Irish Longitudinal Study on Ageing (TILDA)
May, P., Normand, C., Matthews, S., Kenny, R. A., Romero-Ortuno, R. & Tysinger, B., 2022, In: HRB Open Research. 5, 21.Research output: Contribution to journal › Article › peer-review
Computational analysis of learning in young and ageing brains
Hewavitharana, J., Steinhofel, K., Giese, K. P., Ierardi, C. M. & Anand, A., 6 May 2025, In: Frontiers in Computational Neuroscience. 19, 1565660.Research output: Contribution to journal › Article › peer-review
Social support, cognition, and mental health among older people in China: A longitudinal life course study
Long, C., Yang, W. & Glaser, K., Sept 2025, In: Social Science & Medicine. 381, 118279.Research output: Contribution to journal › Article › peer-review
The epidemiology and burden of ten mental disorders in countries of the Association of Southeast Asian Nations (ASEAN), 1990–2021: findings from the Global Burden of Disease Study 2021
Szucs, A., van der Lubbe , S. C., Arias de la Torre, J., Valderas, J. M., Hay, S. I., Bisignano, C., Morgan, B. W., GBD 2021 ASEAN Mental Disorders Collaborators, Murray, C. J. L., Santomauro, D. F. & Ng, M., Jun 2025, In: The Lancet Public Health. 10, 6, p. e480-e491Research output: Contribution to journal › Article › peer-review
Green Infrastructure Strategies for Ageing Populations: Enhancing Health and Well-Being Through Sustainable Urban Design
Horta Reis Da Silva, T., 16 May 2025, Sustainable Development Goals (SDG) and Its Intersection With Health and Well-Being. Poddar, S. & Ansar, W. (eds.). IGI Global Scientific Publishing, p. 207-232 26 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
Assary, E., Coleman, J., Hemani, G., Van De Weijer, M., Howe, L. J., Palviainen, T., Grasby, K. L., Ahlskog, R., Nygaard, M., Cheesman, R., Lim, K., Reynolds, C. A., Ordoñana, J. R., Colodro-Conde, L., Gordon, S. G., Madrid-Valero, J. J., Thalamuthu, A., Hottenga, J.-J., Mengel-From, J. & Armstrong, N. J. & 32 others, Sachdev, P., Lee, T., Brodaty, H., Trollor, J. N., Wright, M. J., Ames, D., Catts, V. S., Latvala, A., Vuoksimaa, E., Mallard, T. T., Harden, K. P., Tucker-drob, E. M., Oskarsson, S., Hammond, C. J., Christensen, K., Taylor, M. J., Lundström, S., Larsson, H., Karlsson, R., Pedersen, N. L., Mather, K. A., Medland, S. E., Boomsma, D. I., Martin, N. G., Plomin, R., Bartels, M., Lichtenstein, P., Kaprio, J., Eley, T., Davies, N. M., Munroe, P. B. & Keers, R., 10 Jun 2025, In: Nature Human Behaviour.Research output: Contribution to journal › Article › peer-review
Can long-term care insurance reduce catastrophic health and long-term care expenditures among older adults? A quasi-experimental study in China
Long, C., Yang, W. & Glaser, K., 3 Jun 2025, In: European Journal of Ageing. 22, 1, 25.Research output: Contribution to journal › Article › peer-review
Anthocyanin Supplementation in Adults at Risk for Dementia: A Randomized Controlled Trial on Its Cardiometabolic and Anti-inflammatory Biomarker Effects
Borda, M. G., Ramirez-Velez, R., Botero-Rodríguez, F., Baldera, J. P., De Lucia, C., Pola, I., Barreto, G. E., Khalifa, K., Bergland, A. K., Kivipelto, M., Cederholm, T., Zetterberg, H., Ashton, N. J., Ballard, C., Siow, R. & Aarsland, D., 2 May 2025, In: GeroScience. e71079.Research output: Contribution to journal › Article › peer-review
Forecasting the Global Burden of Peripheral Artery Disease from 2021 to 2050: A Population-Based Study
Deng, L., Du, C., Liu, L., Wang, Y., Gu, H., Armstrong, D. G., Mills, J. L., Hochlenert, D., Deng, H., Ran, J., Chen, Y., Jiang, X., Ma, Y., Chen, Q., Deng, W. & “Flow and Toe” Research Team (FORT), 1 Jul 2025, In: Research. 8, 0702.Research output: Contribution to journal › Article › peer-review
Computing with Biological Agents on Networks
Nicolau, D., 2025, (Accepted/In press) In: International Journal of Parallel, Emergent and Distributed Systems.Research output: Contribution to journal › Article › peer-review
Independent evaluation of an 11-CpG panel for age estimation in blood
Refn, M. R., Kampmann, M. L., Vyöni, A., Tfelt-Hansen, J., Sørensen, E., Ostrowski, S. R., Kongstad, M., Aliferi, A., Giangasparo, F., Morling, N., Ballard, D., Børsting, C. & Pereira, V., 31 Mar 2025, In: Forensic Science International: Genetics. 76, 103214.Research output: Contribution to journal › Article › peer-review
Protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery
Witard, O., Hughes, A., Morgan, P., Larsen, M., Herrod, P., Phillips, B. E. & Dhesi, J. K., 5 May 2025, (E-pub ahead of print) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
Integrating palliative care into primary care for older people with multimorbid serious illness: a multinational qualitative cross-sectional study in Sub-Saharan Africa
Nkhoma, K. B., Bates, M. J., van Breevoort, D., Chifamba, D. D., Evans, C. J., Kwaitana, D., Mensah, A. B. B., Mnenula, M. C., Mupaza, L., Opare-Lokko, E. B. A. & Harding, R., 23 Mar 2025, (E-pub ahead of print) In: BMJ Public Health. 3, 1, p. e001355Research output: Contribution to journal › Article › peer-review
Music Therapist’s use of singing, listening, playing instruments and movement with music to improve cognition and reduce neuropsychiatric symptoms in music therapy for people living with dementia
Crabtree, S., Hsu, M.-H., Pool, J. & Odell-Miller, H., 31 May 2025, In: British Journal of Music Therapy. 39, 1Research output: Contribution to journal › Article › peer-review
Best Practices for Implementing Electronic Care Records in Adult Social Care: Rapid Scoping Review
Snow, M., Ribeiro, W. S., Baginsky, M., Di Giorgio, S., Farrelly, N., Larkins, C., Poole, K., Steils, N., Westwood, J. & Malley, J., 14 Feb 2025, In: JMIR Aging. 8, e60107.Research output: Contribution to journal › Article › peer-review
Use of the Adult Social Care Outcomes Toolkit (ASCOT) in research studies: an international scoping review
Rand, S., Smith, N., Welch, E., Allan, S., Caiels, J. & Towers, A.-M., 18 Apr 2025, (E-pub ahead of print) In: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. e088685.Research output: Contribution to journal › Article › peer-review
Family Caregiver Perspectives on Digital Methods to Measure Stress: Qualitative Descriptive Study
Rose, L., Saha, S., Flowers, E., Ang, C.-S., Casson, A. J., Condell , J., Matcham, F., Robinson, T. & Rooksby, J., 24 Apr 2025, In: Journal of Medical Internet Research. 27, e66034.Research output: Contribution to journal › Article › peer-review
Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia
Kelu, J. J. & Hughes, S. M., 13 May 2025, In: Proceedings of the National Academy of Sciences USA. 122, 19, e2422446122.Research output: Contribution to journal › Article › peer-review
Theory of Mind Mediates the Association Between Autistic Traits and Social Isolation in Middle-Aged and Older Adults
Lo, G. H. M., Dale, C., Happe, F. & Stewart, G., 4 Apr 2025, In: Autism research. 18, 6, p. 1234-1244 11 p.Research output: Contribution to journal › Article › peer-review
The quality of life of older carers and the people they support: An international scoping review
Zhang, W., Rand, S., Milne, A., Collins, G. & Silarova, B., Dec 2022, In: Health and Social Care in the Community. 30, 6, p. e3342-e3353Research output: Contribution to journal › Article › peer-review
Awards
Selected Ageing Research Funding at King's:
- HealthTech Research Centre for Dementia and Brain Health (National Institute for Health and Care Research)
- Diverging dynamic resilience: Using twins to identify frailty drivers independent of shared genetics in the context of the COVID-19 pandemic (Wellcome Leap)
- Midlife Aging in the Dunedin Study Phase 52 (Medical Research Council)
- PREDICTOM: Prediction of neurodegenerative disease using an AI driven screening platform (Technology Strategy Board)
- Comparing the phenotypes and trajectories of human ageing associated with exercise or inactivity: with a particular focus on the biology of skeletal muscle and the immune system (Nadace The JetBrains Foundation)
- Mechanisms of vascular smooth muscle cell ageing and calcification –developing a timeline for novel therapeutic interventions (British Heart Foundation)
- TwinsUK Imaging: A Resource for Ageing Research (Chronic Disease Research Foundation)
- Mathematical modelling of muscle stem cell behaviour in ageing (Leverhulme Trust)
- The Sciences of ageing and the culture of youth: 1880 to the present day (MRC Medical Research Council)
- Microvascular dysfunction and inflammation in the brain ageing (Stavanger University Hospital),
- Decoding the role of follicle stimulating hormone in ovarian ageing (BBSRC Biotechnology and Biological Sciences Research Council)
- Modelling brain ageing using neuroimaging to improve brain health in older adults (MRC Medical Research Council)
- The influence of TRPA1 signalling on the response to cold exposure as ageing occurs (BBSRC Biotechnology and Biological Sciences Research Council),
- Function of post-translational modifications of protein backbones in signalling and molecular ageing (Wellcome Trust)
- Promoting mental wellbeing in the ageing urban population: determinants, policies and interventions in European cities - MINDMAP (EC European Commission)
- Epigenetic responses to social and environmental cues in early life and over the life course: impact on healthy ageing in UK population-based cohorts (ESRC Economic and Social Research Council)
- Lifecourse biological pathways underlying social differences in healthy ageing (LIFEPATH) (EC European Commission)
- The underlying mechanisms of ageing in the inner ear (BBSRC Biotechnology and Biological Sciences Research Council)
- Colorado adoption/twin Study of lifespan behavioural development and cognitive ageing (CATSLife) (NIH National Institutes of Health)
- ATHLOS - ageing trajectories of health: longitudinal opportunities and synergies (EC European Commission)
- Multi-scale analysis of B cell responses in ageing (MRC Medical Research Council)
- Mechanisms of vascular smooth muscle cell ageing and calcification (BHF British Heart Foundation)
- The role of multi-innervated dendritic spines in memory formation in ageing (BBSRC Biotechnology and Biological Sciences Research Council)
- Exploring frailty, mental health and related outcomes: a multi-cultural population based approach to ageing (MRC Medical Research Council)
- Midlife pace of ageing in the Dunedin study (MRC Medical Research Council)
Activities
Ageing Research at King's Events
ARK hosts events on ageing and healthy longevity across a broad spectrum of themes with a life course approach with UK and international speakers from academia, industry, foundations and governments. Talks have covered themes including entrepreneurship, commercialization, digital innovation, social impact and economics of ageing and government policy, biomarkers of ageing, age-related conditions, physical activity, nutrition, basic and clinical ageing research.
Centre for Integrative Chinese Medicine
ARK has partnered with the Centre for Integrative Chinese Medicine, a multidisciplinary research initiative across KCL and King's Health Partners which aims to integrate traditional Chinese medicine (TCM) with conventional clinical practice.
Early Adopters of Our Future Health
ARK Director Richard Siow and Advisory Board member Cathryn Lewis are selected as Research Ambassadors for Our Future Health's Early Adopters programme. The initiative aims to gather data from up to 5 million adults in the UK to discover new ways to prevent, detect and treat diseases and help everyone live longer and healthier lives.
ARK Longevity Week 2024
The ARK Longevity Week event in November 2024, in partnership with European Society of Preventive Medicine and Longevity Science Foundation, focused on innovations in prevention across the lifespan. The Keynote was given by Nathan Price, Buck Institute, California with industry speakers from Dexcom, Aktivo Labs and Muhdo Health
ARK partners the EMPOWER Dementia Network
The EMPOWER network will assess the growing need for high-quality dementia care, funded by the Alzheimer's Society, Economic and Social Research Council and National Institute for Health and Care Research. Led by Prof Catherine Evans, Faculty of Nursing, Midwifery & Palliative Care, the project will also span the Institute of Psychiatry, Psychology and Neuroscience and Faculty of Social Science & Public Policy.
International Symposium on Metallomics
We are pleased to partner with the 9th International Symposium on Metallomics (17-21 June 2024) hosted at King's College London. The field of metals in ageing research bridges numerous disciplines and is crucial for developing solutions to human and environmental issues in ageing societies. ARK will convene a panel discussion with leading experts on metals in healthy ageing and longevity.
Centre for Ageing Resilience in a Changing Environment (CARICE)
ARK is pleased to incorporate CARICE, a new centre of excellence within the Faculty of Life Sciences & Medicine. The centre mission is to centralise and focus ageing research across the faculty to reduce the negative collective impact of the major colliding global challenges of climate change and population ageing.
NIHR centre to aid diagnosis and treatment of dementia
The new HealthTech Research Centre for Brain Health, established through £2.9m funding from National Institute for Health and Care Research, aims to accelerate the advancement of cutting-edge technology to better understand brain health and ageing and help people live healthier lives for longer. The Centre will be associated with ARK and led by Dag Aarsland, Head, Centre for Healthy Brain Ageing and ARK Co-Director.
PREDICTOM - Early Dementia Detection
The new PREDICTOM project, led by Dag Aarsland, at KCL and Stavanger University Hospital, was funded to develop AI platforms capable of identifying people at risk of dementia before the first symptoms appear. ARK will be associated with the consortium of 30 partners from more than 15 countries include universities, businesses, institutes and hospitals and is backed by €21m funding from the EU Innovative Health Initiative and industry.
ARK Longevity Week 2023 Event
ARK hosted "Sustainable Longevity: Harnessing Consumer HealthTech and FinTech" in partnership with European Society of Preventive Medicine (ESPM), Longevity Science Foundation and Longevity Forum, as part of Longevity Week in November 2023. The event included our ARK Entrepreneur in Residence and speakers from Mastercard UK, Nestle Health Sciences, Muhdo Health, Huumans, William Harvey Heart Centre at Queen Mary and ESPM.
European Society of Preventive Medicine partnership
The ESPM - ARK partnership will facilitate the intersection of basic research, clinical medicine, and community physical, mental and financial health with a focus on the prevention and prediction of chronic and age-related diseases across the lifespan. Prof Pekka Puska, ESPM President spoke at the launch event on 27 September 2023 which included a keynote by Raghib Ali OBE, CEO of Our Future Health.
MRC Award to Extend Dunedin Study
An ARK Team led by Terrie Moffitt with Avshalom Caspi, Dag Aarsland and Richard Siow have been awarded £1.4m by the MRC to quantify the pace of ageing for the Dunedin Study in 8 domains: biological aging, functional aging, facial aging, social aging, sexual aging, inflammatory aging, microvascular aging, and cognitive aging.
Physiological Society AI for Health Report
ARK Director Richard Siow Chaired the Steering Committee of a new Physiological Society report which highlights physiology’s role in unlocking the potential of artificial intelligence for health. The report was launched at the House of Lords on 27 June 2023 hosted by Viscount Stansgate and Stephen Metcalf MP. Dr Siow and ARK Entrepreneur in Residence Svitlana Surodina, were invited speakers.
Longevity Science Foundation Partnership
The ARK-LSF partnership launch was hosted by the School of Academic Psychiatry and included talks by Lisa Ireland (CEO, LSF), Guy Goodwin (CMO, COMPASS Pathways), Allan Young (Vice-Dean, Academic Psychiatry) and Dag Aarsland (Head, Old Age Psychiatry). The partnership will advance research and education in healthy ageing, longevity and psychological well-being.
Oxford Ageing Research Hub Partnership
The University of Oxford Ageing Research Collaborative Hub (ARCH) partnership aims to develop research collaborations, public engagement events, education initiatives and academic exchanges with ARK. ARCH includes the Institute of Population Ageing and Oxford Ageing Network (OxAgeN).
UK National Innovation Centre for Ageing (NICA) Partnership
ARK has partnered with NICA at Newcastle University to establish joint education, research and innovation activities. This will be initiated through a King's based VOICE chapter, symposia and researcher exchanges. Together with Collider Health, NICA launched the "Quantum Healthy Longevity" initiative at a Longevity Week event hosted by ARK with Keynote by Lord James Bethell.
ARK Longevity Week 2022 Event
The ARK hybrid event "Data-Driven Longevity: Digital technologies for collaborative innovation and healthy longevity" on 18 November included a keynote lecture by Sarah Harper, Director, Institute of Ageing, University of Oxford and talks by ARK academic and industry partners. The program and recordings are available below.
SleepCity at King's partners with ARK
The Sleep and Brain Plasticity Centre (SleepCity) at King's is a collaboration between Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience and Sleep Disorders Centre at Guy’s Hospital. ARK related projects will explore the role of sleep on cognitive ageing, neurodegeneration and interventions for healthy longevity.
ARK Partners with Centre for Mental Health Research & Innovation
King's new Centre for Mental Health Research & Innovation led by Allan Young, Vice Dean, Institute of Psychiatry, Psychology & Neuroscience, will be developing a partnership with ARK. In collaboration with the South London & Maudsley NHS Foundation Trust and COMPASS Pathways, research in the Centre will include psychedelics, cannabinoids and new models of care for mental and cognitive wellness in ageing societies.
ARK partners with RADAR-AD
ARK is pleased to partner with Remote Assessment of Disease and Relapse - Alzheimer’s Disease, a platform led by Prof Dag Aarsland, Head of Old Age Psychiatry at King's, to transform patient care through remote assessment using mobile technologies to identify digital biomarkers for predicting deterioration. This consortium of academic and industry members is funded by the European Commission Innovative Medicines Initiative.
Longevity Week 2021 - Innovations in Consumer Longevity Data
ARK hosted "Innovations in Consumer Longevity Data: A Global Perspective" on 19 November, highlighting the UN Decade of Healthy Ageing (keynote by Ritu Sadana, WHO) and the Open Life Data Framework (APPG for Longevity). Organisations represented included University of Zurich, National University of Singapore, AXA Health, Legal & General, Nestle Health Sciences Institute, Deep Longevity, Insilico Medicine and Longevity Science Foundation. The event was opened by Prof Reza Razavi, King's Vice President (Research).
Zurich Healthy Longevity Innovation Cluster - ARK Strategic Partnership
ARK has established a strategic partnership with the University of Zurich (UZH) Innovation Hub to facilitate academic exchange and industry engagement between King's and UZH through their Healthy Longevity Innovation Cluster, Dynamics of Healthy Ageing Research Priority Program and WHO Healthy Ageing Centre. The UK Embassy in Bern celebrated the partnership in late September 2021 by hosting an event including UZH Vice President (Research), King's Global Envoy (Health) and Head of WHO Decade of Healthy Ageing.
Biological ageing R&D with Muhdo Health
ARK has established a collaboration in healthy ageing and informatics with Muhdo Health a consumer epigenetics platform. Together with ARK academics and industry partners, Muhdo aims to develop the next generation of technologies to better assess biological age by integrating biomarkers with lifestyle and environmental data through advanced data analytics.
Nobel Laureate Prof Sir Peter Ratcliffe speaks at Metallomics and Oxygen Symposium
The London Metallomics Facility and ARK jointly hosted a symposium on 5 May 2021 featuring a keynote lecture by Prof Sir Peter Ratcliffe FRS, Director of Clinical Research at the Francis Crick Institute and Director of the Target Discovery Institute at Oxford University. He won the Nobel prize in Physiology or Medicine in 2019 jointly with William Kaelin (Harvard University) and Gregg Semenza (Johns Hopkins University), for their 'discoveries of how cells sense and adapt to oxygen availability'. Prof Reza Razavi, King's VP (Research) gave the vote of thanks.
International Longevity Policy & Governance Summit - Longevity Week 2020
ARK hosted the Second Longevity Policy and Governance Summit as part of Longevity Week 2020, with the theme to address the challenges of ageing societies globally we can strive to ensure healthier, longer lives can be achieved by all. The keynote lecture was given by Prof Sir Robert Lechler, King's Provost and Senior VP (Health).
All Party Parliamentary Group for Longevity: National Strategy Launch, February 2020
As a founding member of the APPG for Longevity, ARK hosted the launch of the "Health of the Nation" report with keynote lecture by the Health Secretary Rt Hon. Matt Hancock MP and talks by Damian Green MP, Lord Geoffrey Filkin, Jon Ashworth MP, Lord Kerslake, Lord O’Shaughnessy, Prof Sir Robert Lechler, KCL Provost and Senior VP (Health) and other distinguished speakers.
AI for Longevity Summit - Longevity Week 2019
ARK hosted the first AI for Longevity Summit at King's on 12 November 2019. This event included participation by financial institutions, insurance and technology companies and policy makers from across the public and private sectors. This summit led to the establishment of the Longevity AI Consortium and highlighted the importance of AI for R&D in healthy ageing. Prof Reza Razavi, King's VP (Research) and Director of the AI Centre for Value Based Healthcare participated in the summit.
International Longevity Policy & Governance Summit - Longevity Week 2019
ARK hosted the International Longevity Policy and Governance as part of Longevity Week 2019, bringing together policy experts, representatives of government bodies, healthcare and finance ministries, executives of healthcare and financial corporations to discuss initiatives for enhancing longevity. The event highlighted the international response to harnessing the opportunities of an ageing demographic, with lessons learned and shared across countries from a policy perspective – taking societal, cross sector and government approaches.
Insilico Medicine and ARK collaborate in AI for Healthy Longevity
Insilico Medicine, a biotech company developing the end-to-end drug discovery pipeline utilizing next-generation artificial intelligence, announces its partnership with ARK - dedicated to enhancing multidisciplinary research collaborations across King’s and King’s Health Partners to better understand the mechanisms of ageing and improving health-span.
Funding for ARK research on physical activity for healthy longevity
ARK researchers in the Centre for Human & Applied Physiological Sciences at KCL have been awarded £1.5m by Nadace The JetBrains Foundation to explore the effects of inactivity on physiological function. In collaboration with University of Birmingham, researchers examined the health of older adults who regularly exercised and the impact this had on ageing.
Vascular Healthy Ageing Research at King's BHF Centre of Excellence funded by BIRAX
The King's School of Cardiovascular Medicine and Sciences (Prof Manuel Mayr) together with the Hebrew University of Jerusalem (Prof Eli Keshet) were awarded funding in 2019 by the British Council BIRAX programme for a novel approach to combat age-associated deterioration of vascular function. Given the multiple roles of the vascular system, they propose that certain interventions can be geroprotective.
Launch of BIRAX Ageing Programme
The British Council UK-Israel Research and Academic Exchange Programme in Healthy Ageing was launched at the BIRAX conference hosted by ARK in September 2018. The conference was opened by David Quarrey, British Ambassador to Israel, Prof Lord Robert Winston & Prof Ruth Arnon, Co-Chairs, UK-Israel Science Council, Christian Duncumb, Director, British Council Israel and Prof Reza Razavi, King's Vice President (Research).
Keynote Event - Prof Sir Edward Byrne and Prof Sir Salvador Moncada
On 31 May 2018 ARK hosted a keynote event with talks by Prof Sir Edward Byrne AC, President & Principal of King’s and Prof Sir Salvador Moncada FRS, FMedSci, School of Medical Sciences, University of Manchester. Prof Byrne spoke about mitochondria in ageing and Prof Moncada highlighted his distinguished research on nitric oxide in physiology and pathophysiology. Prof Sir Robert Lechler, Provost & Senior Vice President (Health) and Executive Director, King's Health Partners gave the vote of thanks.
News
King's academics present their research at healthy ageing events in China
Researchers from King’s College London recently attended two events in China that shared insights into international strategies to promote healthy ageing and...
Study explores how a supplement containing components of the Mediterranean diet can affect epigenetics associated with healthy ageing
Participants taking the supplement showed changes in blood biomarkers and the epigenetic regulation of DNA, which are associated with healthy ageing.
New HealthTech Research Centre in Brain Health celebrates launch
Over 100 guests celebrated the launch of the new centre at the London Institute for Healthcare Engineering (LIHE) on 11 June 2024.
King's College London part of €21 million PREDICTOM study to pioneer early detection of Alzheimer's Disease
A new AI-screening platform to be developed to identify individuals at risk of developing dementia, even before symptoms manifest.
£2.9m for new centre to aid diagnosis and treatment of dementia
New National Institute for Health and Care Research (NIHR) HealthTech Research Centre is designed to accelerate the advancement of cutting-edge technology to...
Events
NIHR HealthTech Research Centre in Brain Health - Industry Panel Meeting 3
HealthTech Research Centre Industry Panel
Please note: this event has passed.
Ethical AI: Safer and Faster Innovation in Healthy Brain Ageing
Ethical AI: a safer, faster innovation in Healthy Ageing & Brain Health
Please note: this event has passed.
New Ways to Support Older People: The Role of Technology in Social Care
Join us for the 2025 Institute of Gerontology Lecture hosted in collaboration with the Gateway to Global Aging Data at King’s College London
Please note: this event has passed.
transCampus International Roadshow - Kuwait
Transcampus - ARK event in Kuwait
Please note: this event has passed.
ARK Global
ARK Partners in Europe
- UK National Innovation Centre for Ageing
- University of Exeter, UK
- MIA - University of Coimbra, Portugal
- Charité Universitätsmedizin Berlin, Germany
- German Institute of Human Nutrition
- Freie Universität Berlin, Germany
- Karolinska Institutet, Sweden
- Norwegian Centre on Healthy Ageing
- Stavanger University Hospital, Norway
- TU Dresden (TransCampus), Germany
- University of Zurich, Switzerland
ARK partners in Asia & Australasia
- Monash University, Australia
- Agency for Science, Technology and Research, Singapore
- National University of Singapore
- Keio University, Japan
- Peking University Health Science Center, China
- Southern University of Science & Technology, China
- Southwest Jiaotong University, China
- Chinese University of Hong Kong
- Hong Kong Quantum AI Lab, InnoHK R&D Centre
- Technion Institute of Technology, Israel
Our Partners
ARK facilitates collaborations with researchers across the breadth of King's College London, King's Health Partners and the Health Innovation Network. ARK has affiliated principal investigators in every Faculty at King's including the TransCampus and the Francis Crick Institute. We value our UK and international partners and take a holistic approach to our ageing and longevity collaborations with a view to develop innovative partnerships between academia and industry.
Our partnerships include those listed below and Twins UK, Alzheimer's Research UK, International Society on Ageing & Disease and we are the founding academic member of the UK All Party Parliamentary Group for Longevity.
British Heart Foundation
National Institute for Health Research (NIHR)
Twins UK
Group leads
Director, Ageing Research at King's
Director, Centre for Healthy Brain Ageing
Professor of Human & Applied Physiology
Contact us
Related departments
- Faculty of Life Sciences & Medicine
- Institute of Psychiatry, Psychology & Neuroscience
- Faculty of Dentistry, Oral & Craniofacial Sciences
- Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care
- Faculty of Social Science & Public Policy
- Faculty of Natural, Mathematical & Engineering Sciences
- Faculty of Arts & Humanities
- King’s Business School
- The Dickson Poon School of Law