Multimodal label-free optical diagnosis of early oral cancers
First supervisor: Dr Mads Bergholt
Second supervisor: Professor Richard Cook
Sponsor: KCL (Self-funded)
Mode of study: Full-time
Project duration:3-4 years
Start date: Open until suitable candidate is found
Application deadline: Open until suitable candidate is found
Reference number: 2022/DOCS/04
Oral cancers are severe life-limiting diseases, particularly when discovered in the later stages. Early detection in precancerous or early cancer stages (i.e., carcinoma in situ) is among the most important measures for reducing morbidity and mortality rates in oral cancer patients.
Conventional diagnosis relies on gross inspection and biopsy of the oral cavity which has resulted in 5 year survivals of up to 90% for early tumours. This survival rate however declines to 50% for advanced cancers, highlighting the necessity of early diagnosis as a primary factor in determining patient outcomes.
This project aims to develop a multimodal approach for oral cancer diagnostics using a combination of novel widefield guidance and pointwise optical biopsy. We will an integrated laparoscopic modality based on vascular imaging and molecular profiling using Raman spectroscopy and optical coherence tomography (OCT). We will coregister the widefield vascular images, OCT depth images and Raman molecular profile and performed deep learning for classification of cancer grade and stage.
- microscopy & optics
- Raman spectroscopy
- Quantitative computing methodologies and data analysis
- Undergraduate Degree in Physics / engineering / optics or similar qualification
- Previous research experience in the area of RAMAN imaging and biophotonics
- Interest in developing self & research capabilities in a unique world leading team arena
- Interest in the development and optimisation of diagnostic instruments for clinical cancer diagnostics
To view entry requirements and further general information, see Dental and Health Sciences Research MPhil/PhD prospectus page.
Please apply online at apply.kcl.ac.uk following these steps:
Register a new account/login
Once logged in, select Create a new application
Enter ‘Dental and Health Sciences Research MPhil/PhD (Full-time)/(Part-time)' under Choose a programme. Please ensure you select the correct mode of study
Select the start date
Please note: Applicants must include the project reference number (2022/DOCS/04) in the 'Research proposal' and 'Funding (point 5)' sections of the application.
Applicants are strongly encouraged to discuss projects with the first supervisor prior to submitting an application.
Dr Mads Bergholt
Prof Richard Cook
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