Dr Alexis Lomakin
London Law Trust Medal Fellow and King's Prize Fellow
Centre for Stem Cells & Regenerative Medicine
King's College London
28th Floor, Tower Wing
Great Maze Pond
London SE1 9RT
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Participating in the Fogarty International Research Collaboration Program, Alexis Lomakin obtained his Ph.D. in Cell and Molecular Biology from Lomonosov Moscow State University (Russia) and the University of Connecticut (USA) under supervision of Prof. Elena Nadezhdina and Prof. Vladimir Rodionov. Alexis was subsequently awarded a Leukemia & Lymphoma Society Fellowship to pursue his postdoctoral training in Quantitative Cell Biology with Prof. Gaudenz Danuser at Harvard University (USA). As a Bruce and Betty Alberts Endowed Scholar in Physiology and a Milton L. Shifman Endowed Scholar at the Marine Biological Laboratory in Woods Hole (USA), Alexis complemented his training background by participating in the advanced interdisciplinary research training course “Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches” directed by Prof. Clare Waterman (National Institutes of Health, USA) and Prof. Dyche Mullins (Howard Hughes Medical Institute/University of California San Francisco, USA). Upon completion of his postdoctoral studies in the USA, Dr. Lomakin relocated to Europe with support from the Marie Sklodowska-Curie Actions Program and the French National Agency ‘Campus France’ to join the laboratory of Prof. Matthieu Piel at the Institut Curie in Paris (France). As a senior research fellow in the Piel laboratory, Alexis combined bioengineering and systems biology approaches to understand how tissue cells interact with their local microenvironment. Dr. Lomakin was recently awarded a King's College London/The London Law Trust Medal Fellowship enabling him to set up his independent laboratory at the Centre for Stem Cells & Regenerative Medicine, King’s College London (UK)
Reconstituting the growth of cells and tissues outside the complex environment of the human body allows the study of biological processes in simplified and controlled settings, and is critically important for the advancement of transplantation and regenerative medicine. Making the leap from tissues in vivo to a system of cells cultured in a plastic Petri dish, however, carries the inevitable risk of removing too much context and therefore sacrificing the important biochemical, mechanical, or geometrical constraints that guide the system’s behavior. In response to this challenge, our laboratory focuses on implementing micro- and nano-fabrication technologies to faithfully recapitulate the constraints that are present within human tissues. Combining this approach with molecular genetics, experimental cell biophysics, quantitative videomicroscopy, and computational modeling, we aim at developing a mechanistic understanding of how cells coordinate their morphogenesis and cell fate decisions with the spatiomechanical constraints present in the surrounding tissue environment. We hope that these efforts will help to uncover the environmental code that directs morphogenetic cell behaviors and tissue building, thus contributing to basic cell & tissue science and translational research in tissue engineering.
To find out more about Dr Lomakin's research please visit his website.
Any vacant posts within the Centre for Stem Cells and Regenerative Medicine are advertised on the King's College London HireWire website
Our vision is to solve complex biological problems in cell & tissue research through highly collaborative, international, and multi-disciplinary team science. Therefore, we welcome scholars from all over the world with backgrounds in both the biomedical and physical/computational sciences. If you are interested in opportunities within the Lomakin laboratory, please e-mail Dr. Alexis J. Lomakin