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Cachexia, cancer, exercise, intervention development and testing, muscle outcome measurement, physiology, palliative care, philosophy of science, respiratory disease, rehabilitation, supportive care.

Matt is a specialist physiotherapist committed to developing rehabilitation strategies for people with advanced disease. He is a Senior Lecturer in Health Services Research at the Cicely Saunders Institute, King’s College London, and a National Institute of Health Research Career Development Fellow.  His research interests span palliative care, rehabilitation, and frailty, sarcopenia and cachexia syndromes. He chairs the Rehabilitation Subgroup of the Supportive and Palliative Care National Clinical Studies Group.

• Bayly J, Wakefield D, Hepgul N, Wilcock A, Higginson IJ, Maddocks M. Changing health behaviour with rehabilitation in thoracic cancer: A systematic review and synthesis.Psychooncology. 2018 Feb 24. doi: 10.1002/pon.4684
• Solheim TS, Laird BJA, Balstad TR, Bye A, Stene G, Baracos V, Strasser F, Griffiths G, Maddocks M, Fallon M, Kaasa S, Fearon K. Cancer cachexia: rationale for the MENAC (Multimodal-Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial. BMJ Support Palliat Care. 2018 Feb 9. pii: doi: 10.1136/bmjspcare-2017-001440.
• Nolan CM, Maddocks M, Maher TM, Canavan JL, Jones SE, Barker RE, Patel S, Jacob J, Cullinan P, Man WD. Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis. Respirology. 2017 Nov 14. doi: 10.1111/resp.13213.
• Neo J, Fettes L, Gao W, Higginson IJ, Maddocks M. Disability in activities of daily living among adults with cancer: A systematic review and meta-analysis. Cancer Treatment Reviews. 2017:61: 94–106
• Maddocks M, Lovell N, Booth S, Man WD, Higginson IJ. Palliative care and management of troublesome symptoms for people with chronic obstructive pulmonary disease. The Lancet. 2017;390(10098):988-1002.
• Maddocks M, Delogu V, Jones SE, Polkey MI, Man WD. Exercise Training Versus Neuromuscular Stimulation in Severe Chronic Obstructive Pulmonary Disease. Arch Bronconeumol. 2017 Jul;53(7):357-359. doi: 10.1016/j.arbres.2016.11.022.
• Nolan CM, Kon SSC, Patel S, Jones SE, Barker RE, Polkey MI, Maddocks M, Man WD. Gait speed and pedestrian crossings in COPD. Thorax. 2017 DOI: 10.1136/thoraxjnl-2017-210173.
• Higginson IJ, Reilly CC, Bajwah S, Maddocks M, Costantini M , Gao W, on behalf of the GUIDE_Care project. Which patients with advanced respiratory disease die in hospital? A 14-year population-based study of trends and associated factors. BMC Medicine 2017; 15(1):19.
• Malcolm L, Mein G, Jones A, Talbot-Rice H, Maddocks M, Bristowe K. Strength in numbers: patient experiences of group exercise within hospice palliative care. BMC Palliative Care 2016; 15(1):97
• Bone AE, Hepgul N, Kon S, Maddocks M. Sarcopenia and frailty in chronic respiratory disease: Lessons from gerontology. Chronic Respiratory Disease 2016; 14(1):85–99.
• Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, Banya W, Kon SS, Polkey MI, Man WD. Pedometer Step Count Targets During Pulmonary Rehabilitation in COPD: A Randomized Controlled Trial. Am J Respir Crit Care Med 2016 DOI: 10.1164/rccm.201607-1372OC
• Maddocks M, Kon SS, Jones SE, Canavan JL, Nolan CM, Labey A, Polkey MI, Man WD. Physical frailty and pulmonary rehabilitation in COPD: a prospective cohort study. Thorax 2016 Jun 12 [epub ahead of print]. DOI: 10.1136/thoraxjnl-2016-208460
• Jones S, Man WDC, Gao W, Higginson IJ, Wilcock A, Maddocks M. Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease. Cochrane Database Syst Rev 2016 Oct 17;10: CD009419.
• Maddocks M, Nolan CM, Man WD, Polkey MI, Hart N, Gao W, Rafferty GF, Moxham J, Higginson IJ. Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD: a randomised double-blind, placebo-controlled trial. Lancet Respir Med 2016; 4(1):27–36.
• Maddocks M, Hopkinson J, Conibear J, Reeves A, Shaw C, Fearon KC. Practical multimodal care for cancer cachexia. Curr Opin Support Palliat Care. 2016; 10(4):298-305.
• Maddocks M, Kerry R, Turner A, Howick J. Problematic placebos in physical therapy trials. J Eval Clin Pract 2016; 22(4):598-602.
• Turner K, Tookman A, Bristowe K, Maddocks M. ‘I am actually doing something to keep well. That feels really good’: Experiences of exercise within hospice care. Prog Palliat Care 2016; 24(4):204-12.

MSc programmes at King’s College London (Palliative Care, Human Applied Physiology) and University College London (Advanced Respiratory Management) on outcome measurement, exercise and rehabilitation including management of muscle dysfunction.

• NIHR Career Development Fellowship. Maddocks M, Higginson IJ, Man WD, Lamb SE. Developing 'frailty fit' pulmonary rehabilitation services for people with chronic obstructive pulmonary disease. £564,969 (2017-21).
• NIHR Research for Patient Benefit. Man WD, Nolan C, Maddocks M, Gao W, Yi DH, Spain N, Kon SS. Minimal versus specialist equipment in the delivery of pulmonary rehabilitation: a randomised controlled trial. £346,450 (2012-21).
• NIHR Health Services & Delivery Research. Maddocks M, Gao W, Higginson IJ, Yi DH, Man WD, Farquhar M, Bajwah S, Booth S. An evidence synthesis of holistic services for refractory breathlessness in advanced malignant and non-malignant disease. £128,613 (2017-18).
• NIHR Clinical Doctoral Research Fellowship (ICA-CDRF-2015-01-008). Bayly J, Maddocks M, Higginson IJ, Wilcock A. Developing a short-term integrated rehabilitation service for people with newly diagnosed thoracic cancer. £269,174 (2016-19).
• NIHR Doctoral Research Fellowship. Neuromuscular Electrical Stimulation of the lower limbs: an effective adjunct to Pulmonary Rehabilitation? (NEST-PR). Jones S, Polkey MI, Man WD, Maddocks M. £257,949 (2016-19).
• NIHR Doctoral Research Fellowship (DRF-2014-07-089). C Nolan, Man WD, Maddocks M, Cullinan TP, Maher T. Gait Speed and Prognosis in Idiopathic Pulmonary Fibrosis. £240,074 (2015-18).
• NIHR Post-Doctoral Fellowship (PDF-2011-04-048). Effect of neuromuscular electrical stimulation of the quadriceps on exercise capacity in people with COPD. Maddocks M, Higginson IJ, Moxham J. £311,744 (2011−14).
• WHO Kobe Centre. Evans CJ, Nicholson C, Harding R, Ellis-Smith C, Namisango E, Bajwah S, Yi DK, Gao W, Higginson IJ & Maddocks M. Rapid review of service delivery models for older people at the end of life to maximise quality of life. $43,900 (2017).
• The Dunhill Medical Trust. Understanding the social determinants of outcomes important to older people at the end of life: reducing social inequality in palliative care. Davies J, Murtagh FEM, Maddocks M. £170,406.54 (2016-19).
• The Dunhill Medical Trust. Improving palliative rehabilitation in palliative care using goal attainment scaling. Maddocks M, Higginson IJ, Turner-Stoke L, Siegert R, Ashford S, Harding R, Gao W, Murtagh FE. £134,798 (2015-17).
• British Lung Foundation, Idiopathic Pulmonary Fibrosis project grant. Neuromuscular electrical stimulation in advanced idiopathic pulmonary fibrosis: a randomised placebo-controlled feasibility trial. Nolan C, Man WD, Maddocks M, Scholes J. £ 147,887 (2018-20).
• Marie Curie. ENeRgy: Exercise and Nutritional Rehabilitation in patients with advanced cancer: a single centre, randomised (1:1), open-label, feasibility study of a rehabilitation programme (exercise and nutrition) versus wait list control, in patients with advanced cancer. Fallon M, Laird B, Maddocks M, Graham C, Tuck S, Brown D, Haraldsdottir E, Lloyd A, Whitehouse Y, Dixon L, Finucane A,  Hall P, Skipworth R. £118,135 (2017-19).
• Marie Curie. A randomised, open-label trial of a Multimodal Intervention (Multimodal Exercise, Nutrition and Anti-inflammatory Medication / MENAC) versus standard care in cancer patients with Cachexia. Fearon KCH, Laird B, Kaasa S, Solheim TS, Maddocks M. £454,700 (2016-19).

Membership of Professional bodies:

• Chartered Society of Physiotherapy
• Health Professions Council (Registered Physiotherapist)
• British Thoracic Society
• Allied Health Professions Research Network (Hub Facilitator)
• Association of Chartered Physiotherapists in Oncology & Palliative Care (Executive Committee, Public Relations, Education & Research Officer)
• National Cancer Research Institute Supportive & Palliative Care Clinical Studies Group (full member)
• Society on Cachexia and Wasting Disorders

European Association of Palliative Care - Physiotherapy Taskforce member.