Stuart Neil's research
Wellcome Trust Senior Fellow in Basic Biomedical Science
Department of Infectious Diseases 2nd Floor, Borough Wing King's College London School of Medicine
at Guy's, King's and St Thomas' Hospitals
King's College London
Guy's Hospital, Great Maze Pond
London SE1 9RT
Tel: +44 (0)20 7188 8279
Fax: +44 (0)20 7188 3385
Stuart Neil received his PhD in 2001 from University College London under the supervision of Professor Mary Collins, where he studied lentiviral vector transduction of primary human antigen presenting cells and retroviral vector engineering. From 2001-2005 he was a post-doctoral fellow in the group of Professor Robin Weiss at UCL, working on various aspects of HIV biology including the effects of ABO Bloodgroup Antigens on virus serum sensitivity and viral interactions with novel chemokine co-receptors.
In early 2005 Stuart joined Professor Paul Bieniasz’s group at the Aaron Diamond AIDS Research Center/Rockefeller University in New York. Here he characterized the nature of the restriction to retroviral particle release that is counteracted by the HIV-1 accessory protein Vpu, showing that an interferon induced factor “tethered” nascent virions to the surface of infected cells in the absence of Vpu expression, and that this factor was antiviral for other enveloped viruses. This allowed him to identify tetherin (BST2/CD317) as the antiviral protein responsible.
Stuart was awarded a Wellcome Trust Research Career Development Fellowship and took up a position at KCL in January 2008. His lab currently studies various aspects of HIV/host interactions, particularly the role of tetherin in the pathogenesis of HIV/AIDS and the molecular basis of its evasion by Vpu and other viral antagonists.