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Mood & Development Lab

Dr Argyris Stringaris

Dr Argyris Stringaris

I am a clinician scientist funded by the Wellcome Trust to study mood in health and disease across human development. I trained at the Maudsley Hospital (MRCPsych), the Institute of Psychiatry at King’s College London (PhD) and the National Institutes of Health (Clinical Research Fellow) in the USA. I am married to Kate, née Taylor, a haematologist from London, and we have three daughters; Clara Maria, Sophia and Alice.

My aim is to understand what makes some people more depressed, irritable or euphoric than others and how changes in mood affect the wellbeing of people. My colleagues and I use epidemiological, imaging, and genetic methods to answer these questions. Our work was awarded the 2014 Klingenstein Foundation Prize by the American Academy of Child and Adolescent Psychiatry, and the European Psychiatric Association (EPA) Research Prize for 2010. It is funded by the Wellcome Trust and the Biomedical Research Centre.

Disruptive-Mood-Book-Cover-Picture

As a consultant psychiatrist, I see and treat children and families who suffer from depression, bipolar disorder or severe irritability. Our team, the National and Specialist Mood Disorder Clinic in the Michael Rutter Centre of the Maudsley Hospital, provides a specialist multidisciplinary service for children with depression, bipolar disorder and severe irritability. 

My latest book, co-authored with Professor Eric Taylor, is on the subject of irritability. Disruptive Mood: Irritability in Children and Adolescents was recently published by Oxford University Press.

Research Interests

DEVELOPMENTAL PATHWAYS TO DEPRESSION

Our work has shown that irritable children are more likely to become depressed later in life. We have also found that many of the problems that are often labelled as “disruptive behaviours” are problems of mood regulation. We are studying the genetic, neuropsychological, and hormonal mechanisms that underlie mood regulation, using long-term follow up and twin studies. 

EARLY-LIFE PRESENTATION OF MANIA AND ITS TREATMENT

Many people with bipolar (manic-depressive) disorder report having experienced psychological problems early in life. However, the ways in which bipolar disorder can present in the young is a topic of debate and intense scientific interest. We use community- and clinic-based studies to discover the early-life presentation of bipolar symptoms.

BRAIN MECHANISMS OF MOOD DYSREGULATION


The ways in which the brain regulates emotional responses seem to vary by developmental stage. We are working on a project that uses functional imaging (Arterial Spin Labelling) to understand how regional cerebral blood flow (rCBF) varies during transitions of mood states in young people. We hope to detect mood changes in those who find it difficult to express emotions (e.g. children with autism), and also monitor how medication may affect mood.

MEASUREMENT OF MOOD AND BEHAVIOUR

We want to improve the way mood states and mood fluctuations are measured in young people. We have recently developed the Affective Reactivity Index, a concise instrument to measure irritability and are now working on an in-depth interview to capture mood changes.

Publications

Click here to access an article by Dr Stringaris.

Journal Publications

Koukounari A, Stringaris AMaughan B (2016). Pathways from maternal depression to young adult offspring depression: an exploratory longitudinal mediation analysis. International Journal of Methods in Psychiatric Research (in press).

Vidal-Ribas P, Brotman MA, Valdivieso I, Leibenluft E, Stringaris A (2016). The status of irritability in psychiatry: a conceptual and quantitative review. Journal of the American Academy of Child & Adolescent Psychiatry, 55(7):556-570. 

Mikita N, Simonoff E, Pine DS, Goodman R, Artiges E, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Cattrell A, Conrod PJ, Desrivières S, Flor H, Frouin V, Gallinat J, Garavan H, Heinz A, Ittermann B, Jurk S, Martinot JL, Paillère Martinot ML, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Smolka MN, Walter H, Whelan R, Schumann G, Stringaris A (2016). Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study. Translational Psychiatry, 6(6):e845.

Cortese S, Ferrin M, Brandeis D, Holtmann M, Aggensteiner P, Daley D, Santosh P, Simonoff E, Stevenson J, Stringaris A, Sonuga Barke E (2016). Neurofeedback for attention-deficit/hyperactivity disorder: meta-analysis of clinical and neuropsychological outcomes from randomized controlled trials. Journal of the American Academy of Child & Adolescent Psychiatry, 55(6):444-455.

Kaurin A, Egloff B, Stringaris A, Wessa M (2016). Complementary voices tell the truth: A reevaluation of validity in multi-informant approaches of child and adolescent clinical assessments. Journal of Neural Transmission [in press]. 

Perez Algorta G, Lamont Dodd A, Stringaris A, Youngstrom E (2016). Diagnostic efficiency of the SDQ for Parents to identify ADHD in the UK: A ROC analysis. European Child & Adolescent Psychiatry [in press]. 

Benarous X, Mikita N, Goodman R and Stringaris A (2016). Distinct relationships between social aptitude and dimensions of manic-like symptoms in youth. European Child & Adolescent Psychiatry [in press].

Aebi M, van Donkelaar M, Poelmans G, Buitelaar J, Sonuga-Barke E, Stringaris A, IMAGE consortium et al. (2016). Gene-Set and Multivariate Genome-Wide Association Analysis of Oppositional Defiant Behavior Subtypes in Attention-Deficit/Hyperactivity Disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [in press].

Medford N, Sierra M, Stringaris A, Giampietro V, Brammer MJ, David A (2016). Emotional experience and awareness of self: functional MRI studies of depersonalization disorder. Frontiers in Psychology, 7:432.

Songua-Barke EJ, Cortese S, Fairchild G, Stringaris A (2016). Transdiagnostic neuroscience of child and adolescent mental disorders: differentiating decision-making in attention-deficit/hyperactivity disorder, conduct disorder, depression and anxiety. Journal of Child Psychology and Psychiatry, 57(3):321-49.

Hoffmann MS, Leibenluft E, Stringaris A, Laporte PP, Pan PM, Gadelha A, Manfro GG,  Miguel EC, Rohde LA, Salum GA (2016). Positive attributes “buffer” the negative associations between low intelligence and high psychopathology with educational outcomes. Journal of the American Academy of Child & Adolescent Psychiatry, 55(1):47-53.

Stringaris A*, Vidal-Ribas Belil P*, Artiges E*, Lemaitre H, Gollier-Briant F, Wolke S, Vulser H et al. (2015). The brain’s response to reward anticipation and depression in adolescence: dimensionality, specificity and longitudinal predictions in a community-based sample. American Journal of Psychiatry, 172(12):1215-23.

Mikita N, Mehta MA, Zelaya FO, Stringaris A (2015). Using arterial spin labelling to examine mood states in youth. Brain and Behavior, 5(6):e00339.

Vulser H, Lemaitre H, Artiges E, Stringaris A, Schumann G, Martinot JL, Paillère-Martinot ML (2015). Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 54(10):832-40.

Whelan YM, Leibenluft E, Stringaris A, Barker ED (2015). Pathways from maternal depressive symptoms to adolescent depressive symptoms: the unique contribution of irritability symptoms. Journal of Child Psychology and Psychiatry, 56(10):1092-1100.   

Mikita N, Hollocks MJ, Papadopoulos AS, Aslani A, Harrison S, Leibenluft E, Simonoff E, Stringaris A (2015). Irritability in boys with autism spectrum disorders: an investigation of physiological reactivity. Journal of Child Psychology and Psychiatry, 56(10):1118-1126.

Deveney CM, Hommer RE, Reeves E, Stringaris A, Hinton KE, Haring CT, Vidal-Ribas P, Towbin K, Brotman MA, Leibenluft E (2015). A Prospective Study of Severe Irritability in Youths: 2 and 4 Year Follow-Up. Depression and Anxiety, 32(5):364-372. 

Kyriakopoulos M, Stringaris A, Manolesou S, Radobuljac MD, Jacobs B, Reichenberg A, Stahl D, Simonoff E, Frangou S (2015). Determination of psychosis-related clinical profiles in children with autism spectrum disorders using latent class analysis. European Child & Adolescent Psychiatry, 24(3):301-307. PMCID: PMC4224587.

Cortese S, Ferrin M, Brandeis D, Buitelaar J, Daley D, Dittmann RW, Holtmann M, Santosh P, Stevenson J, Stringaris A, Zuddas A & Sonuga-Barke E (2015). Cognitive Training for Attention-Deficit/Hyperactivity Disorder: Meta-Analysis of Clinical and Neuropsychological Outcomes from Randomized Controlled Trials. Journal of the American Academy of Child & Adolescent Psychiatry, 54(3):164-174.

Vidal-Ribas P, Stringaris A, Rück C, Serlachius E, Lichtenstein P, Mataix-Cols D (2015).  Are stressful life events causally related to the severity of obsessive compulsive symptoms? A monozygotic twin difference study. European Psychiatry, 30(2):309-16. 

Vidal-Ribas P, Goodman R, Stringaris A (2015). Positive attributes and reduced risk of future psychopathology. British Journal of Psychiatry,  206(1):17-25.  

2013-14

Stringaris A, Ryan-Castellanos N, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Büchel C et al. (2014) Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample. Journal of Child Psychology Psychiatry, 55(12):1380-1389. PMCID: PMC4167034.

Wiggins JL, Mitchell C, Stringaris A, Leibenluft E (2014). Developmental Trajectories of Irritability and Bidirectional Associations With Maternal Depression. Journal of the American Academy of Child and Adolescent Psychiatry, 53(11):1191-1205, 1205e1-4. PMCID: PMC4254549.   

Fernández de la Cruz L, Simonoff E, McGough JJ, Halperin JM, Arnold L.E & Stringaris A (2014). Treatment of children with  Attention Deficit Hyperactivity Disorder (ADHD) and irritability: Results from the Multimodal Treatment Study of Children with ADHD (MTA). Journal of the American Academy of Child and Adolescent Psychiatry, 54(1):62-70.e3. PMCID: PMC4284308.

Stringaris A, Lewis G, Maughan B (2014). Developmental pathways from child and adolescent conduct problems to early adult depression: findings from the Avon Longitudinal Study of Parents and Children. British Journal of Psychiatry, 205:17-23. PMCID: PMC4076653.

Stoddard J, Stringaris A, Brotman MA, Montville D, Pine DS, Leibenluft E (2014). Irritability in child and adolescent anxiety disorders. Depression and Anxiety, 31(7):566-73. PMCID: PMC3937265.

Pan PM, Salum GA, Gadelha A, Moriyama T, Cogo-Moreira H, Graeff-Martins AS, Rosario MC, Polanczyk GV, Brietzke E, Rohde LA, Stringaris A, Goodman R, Leibenluft E, Bressan RA (2014). Manic symptoms in youth: dimensions, latent classes, and associations with parental psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, 53(6):625-634. 

Bolhuis K, McAdams TA, Monzani B, Gregory, AM, Mataix-Cols D, Stringaris A & Eley TC (2014). Aetiological overlap between obsessive-compulsive and depressive symptoms: a longitudinal twin study in adolescents and adults. Psychological Medicine, 44(7):1439-49. PMCID: PMC3959155. 

Shaw P, Stringaris A, Nigg J, Leibenluft E (2014). Emotion dysregulation in Attention Deficit Hyperactivity Disorder. American Journal of Psychiatry, 171:276-93 PMCID: PMC4282137.

Moyá J, Stringaris AK, Asherson P, Sandberg, S & Taylor E (2014). The Impact of Persisting Hyperactivity on Social Relationships: A Community-Based, Controlled 20-Year Follow-Up Study. Journal of Attention Disorders, 18(1):52-60. 

Dougherty LR, Smith VC, Bufferd, SJ, Carlson GA, Stringaris A, Leibenluft E, and Klein DN (2014) Disruptive mood dysregulation disorder: correlates and predictors in young children. Psychological Medicine, 44(11):2339-2350.

Dougherty LR, Smith VC, Bufferd SJ, Stringaris A, Leibenluft E, Carlson GA & Klein DN (2013). Preschool Irritability: Longitudinal Associations With Psychiatric Disorders at Age 6 and Parental Psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, 52(12):1304-1313. PMCID: PMC3860177.

Krieger FV & Stringaris A (2013). Bipolar disorder and disruptive mood dysregulation in children and adolescents: assessment, diagnosis and treatment. Evidence-Based Mental Health, 16(4):93-94. 

Stringaris A & Goodman R (2013). The Value of Measuring Impact Alongside Symptoms in Children and Adolescents: A Longitudinal Assessment in a Community Sample. Journal of Abnormal Child Psychology, 41(7):1109-1120. PMCID: PMC3755220. 

DeSousa DA, Stringaris A, Leibenluft E, Koller SH, Manfro GG & Salum GA (2013). Cross-cultural adaptation and preliminary psychometric properties of the Affective Reactivity Index in Brazilian youth : Implications for DSM-5 measured irritability. Trends in Psychiatry and Psychotherapy, 35(3):171-180. 

Whelan YM, Stringaris A, Maughan B & Barker E (2013). Developmental Continuity of Oppositional Defiant Disorder Subdimensions at Ages 8, 10, and 13 Years and Their Distinct Psychiatric Outcomes at Age 16 Years. Journal of the American Academy of Child and Adolescent Psychiatry, 52(9):961-9. PMCID: PMC4026040. 

Stringaris A, Maughan B, Copeland W, Costello J, Angold, A (2013). Irritable Mood as a Symptom of Depression in Youth: Prevalence, Developmental, and Clinical Correlates in the Great Smoky Mountains Study. Journal of the American Academy of Child and Adolescent Psychiatry, 52, 831-40. PMCID: PMC3728563.

Krieger FV, Polanczyk G, Goodman R, Rohde LA, Graeff-Martins AS, Salum GA, Pan P, Gadelha A, Stringaris A (2013). Dimensions of oppositionality in a Brazilian community sample: testing the DSM-5 proposal and etiological links.Journal of the American Academy of Child and Adolescent Psychiatry, 52, 389-400. PMCID: PMC3834546.

Maughan B, Collishaw S. & Stringaris A (2013). Depression in Childhood and Adolescence. Journal of the Canadian Academy of Child and Adolescent Psychiatry. 22(1):35-40. PMCID: PMC3565713.

Mikita N & Stringaris A (2013). Mood Dysregulation. European Child & Adolescent Psychiatry, 22(Suppl.1):S11-16. PMCID: PMC3560944. 

Krieger FV, Leibenluft E, Stringaris A, Polanczyk GV (2013). Irritability in children and adolescents: past concepts, current debates, and future opportunities. Revista Brasileira de Psiquiatria, 35(Suppl 1):S32-9.

2011-12

Stringaris A, Zavos H, Leibenluft E, Maughan B, Eley T (2012). Adolescent irritability: phenotypic associations and genetic links with depressed mood.American Journal of Psychiatry, 169, 47-54. PMCID: PMC3660701.

Krebs G, Bolhuis K, Heyman I, Mataix-Cols D, Turner C, Stringaris A (2012).Temper outbursts in pediatric OCD and their association with depressed mood and treatment outcome. Journal of Child Psychology and Psychiatry, 54, 313-322. PMCID: PMC4026039.

Stringaris A, Goodman R, Ferdinando S, Razdan V, Muhrer E, Leibenluft E, Brotman MA (2012). The Affective Reactivity Index: A concise irritability scale for clinical and research settings. Journal of Child Psychology and Psychiatry, 53, 1109-1117. PMCID: PMC3484687.

Leigh E, Smith P, Milavic G, Stringaris A (2012). Mood regulation in youth: research findings and clinical approaches to irritability and short-lived episodes of mania-like symptoms. Current Opinion in Psychiatry, 25(4):271-6. PMCID: PMC3660700. 

Weathers JD, Stringaris A, Deveney C, Brotman MA, Zarate C, Connoly ME, Fromm SJ, LeBourdais SB, Pine D, Leibenluft E (2012). A Developmental Study of the Neural Circuitry Mediating Motor Inhibition in Bipolar Disorder. American Journal of Psychiatry, 169:633-641. PMCID: PMC3466815.

Broome MR, Harland R, Owen GS, Stringaris A (2012). The Maudsley Reader in Phenomenological Psychiatry. Cambridge, UK: Cambridge University Press. 

Aebi M, Kuhn C, Metzke CW, Stringaris A, Goodman R, Steinhausen HC (2012). The use of the development and well-being assessment (DAWBA) in clinical practice: a randomized trial. European Child & Adolescent Psychiatry, 21(10):559-67. PMCID: PMC3866649.

Giora R, Gazal O, Goldstein I, Fein O, Stringaris A (2012). Salience and Context: Interpretation of Metaphorical and Literal Language by Young Adults Diagnosed with Asperger's Syndrome. Metaphor and Symbol, 27:22-54. 

Stringaris A, Stahl D, Santosh P, Goodman R (2011). Dimensions and latent classes of episodic mania-like symptoms in youth: an empirical enquiry.Journal of Abnormal Child Psychology, 39, 925-937. PMCID: PMC3161193.

Chan J, Stringaris A, Ford T (2011). Bipolar Disorder in Children and Adolescents Recognised in the UK: A Clinic-Based Study. Child and Adolescent Mental Health, 16(2):71-78.

Stringaris A (2011). Irritability in children and adolescents: a challenge for DSM-5. European Child & Adolescent Psychiatry, 20(2):61-6.

2010 and earlier

Sobanski E et al. (2010). Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence. Journal of Child Psychology and Psychiatry, 51(8):915-23.

Stringaris A, Baroni A, Haimm C, Brotman, B, Lowe C, Myers F, Rustgi E, Wheeler W, Towbin, K, Leibenluft, E (2010). Pediatric Bipolar Disorder vs. Severe Mood Dysregulation: Risk for Manic Episodes on Follow-up. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 397-405. PMCID: PMC3000433.

Stringaris A, Maughan B, Goodman R (2010). What's in a disruptive Disorder? Temperamental antecedents of ODD: findings from the Avon longitudinal study. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 474-483. 

Stringaris A, Santosh P, Leibenluft E, Goodman R (2010). Youth meeting symptom and impairment criteria for mania-like episodes lasting less than four days: an epidemiological inquiry. Journal of Child Psychology and Psychiatry, 51, 31-38. PMCID: PMC4286871.

Stringaris A, Cohen P, Pine DS, Leibenluft E, (2009). Adult Outcomes of Youth Irritability. A 20-year Community-based follow up study. American Journal of Psychiatry, 166, 1048-54. PMCID: PMC2791884.

Stringaris A, Goodman R. (2009). Longitudinal outcome of youth oppositionality: irritable, headstrong and hurtful behaviors have distinctive outcomes. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 404-12.

Stringaris A, Goodman R (2009). Three dimensions of oppositionality in youth. Journal of Child Psychology and Psychiatry, 50, 216-223.

Stringaris A, Goodman R. (2009). Mood lability and psychopathology in youth. Psychological Medicine, 39, 1237-45. 

Stringaris A, Medford N, Brammer M, Giampietro V, David A (2007). Deriving Meaning: Distinct Neural Mechanisms for Metaphoric, Literal, and Non-Meaningful Sentences. Brain and Language, 100, 150-162. 

Stringaris A, Medford N, Giora R, Brammer M, Giampietro V, David A (2006). How metaphors influence semantic relatedness judgements: the role of the right frontal cortex. NeuroImage, 33, 784-793. 

Books

Stringaris A & Taylor E (2015). Disruptive Mood: Irritability in Children and Adolescents. Oxford, UK: Oxford University Press.

Book Chapters

Krieger FV and Stringaris A (2015). Temperament and Vulnerability to Externalizing Behavior in The Oxford Handbook of Externalizing Spectrum Disorders, Eds. Beauchaine TP and Hinshaw S. Oxford University Press.

Stringaris A (2015). Emotion regulation and emotional disorders: conceptual issues for clinicians and neuroscientists in Rutter’s Child and Adolescent Psychiatry, Sixth Edition, Eds. Thapar A, Pine DS, Leckman JF, Scott S, Snowling MJ, Taylor EA. Wiley-Blackwell. 

Stringaris AK, Asherson P (2008). Molecular Genetics in Child Psychiatry in Advances in Biological Child Psychiatry; Ed. Louis Augusto Rohde, Tobias Banashewski. Karger Publishing. 

Giora R, Stringaris AK (2008). Neural Substrates of Metaphors in The Cambridge Encyclopedia of the Language Sciences (CELS); Ed Patrick Hogan. Cambridge University Press.

Book Editorship

Broome MR, Harland R, Owen GS, Stringaris A (2012). The Maudsley Reader in Phenomenological Psychiatry. Cambridge,UK: Cambridge University Press.

Contact Details
Dr Argyris Stringaris 
Department of Child and Adolescent Psychiatry - PO85
Institute of Psychiatry
16 De Crespigny Park
London
SE5 8AF
 
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